Jin Hwan Do

Publications (3)4.24 Total impact

• Source

  Available from: bcbd.kaist.ac.kr

  Article: Regioselective enzymatic acylation of multi-hydroxyl compounds in organic synthesis

  Hyun Gyu Park, Jin Hwan Do, Ho Nam Chang
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  ABSTRACT: With current developments in enzyme-catalyzed reactions and techniques available for rational redesign of natural biocatalysts, the enzymatic biosynthesis can become one of the most valuable synthetic methods. Enzymatic regioselective catalysis in organic media has played a key role in pursuing asymmetric synthesis for active chiral compounds. Here, we shortly describe some historical issues of the rapidly growing area, enzymatic catalysis in synthetic organic chemistry and then review researches that have been carried out in the regioselective enzymatic catalysis for the past two decades. An application of this technology to the modification of some potential target drug compound will be also presented.
  Biotechnology and Bioprocess Engineering 04/2012; 8(1):1-8. · 1.28 Impact Factor
• Article: Production of poly-γ-glutamic acid by fed-batch culture of Bacillus licheniformis

  Sung Ho Yoon, Jin Hwan Do, Sang Yup Lee, Ho Nam Chang
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  ABSTRACT: Fed-batch cultures of Bacillus licheniformis produced poly--glutamic acid (PGA), a water-soluble biodegradable polymer. PGA reached 35gl–1 with a productivity of 1gl–1h–1 by pulsed-feeding of citric acid (1.44gh–1) and l-glutamic acid (2.4gh–1) when citric acid was depleted from the culture medium.
  Biotechnology Letters 03/2000; 22(7):585-588. · 1.68 Impact Factor
• Source

  Available from: bbe.or.kr

  Article: Biological removal of pyridine in heavy oil byRhodococcus sp. KCTC 3218

  Jin Hwan Do, Woo Gi Lee, Kalaimahan Theodore, Ho Nam Chang
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  ABSTRACT: The removal of organic nitrogen compounds present in crude perroleum and shale oils poses a challenging problem in petroleum industries. The deleterious effect of nitrogen compounds on cracking catalysts and the indication that they contribute to gum formation in gasolines are some of these aspects. Pyridine, a representative nitrogen compound in gaavy oil—was degraded byRhodoccus sp. KCTC 3218 in a water-heavy oil two-phase system. The pyridine degradation rate was affected by the presence of hydrocarbons such as n-hexadecane. This microorganism formed flocs which could be a barrier to mass transfer between the cells in flocs and the pyridine dissolved in water. This problem could be overcome by the addition of a surfactant such as Triton X-100. The ratio of water to heavy oil was important to separate the heavy oil phase from the water phase after treating the heavy oil. The culture medium was emulsified by a sort of biosurfactant secreted by this microorganism. The emulsified oil phase returned to its natural state when the ratio of water to heavy oil was 1.5. Above this ratio, the emulsified oil phase remained an emulsion after decantation. Pyridine in heavy oil was completely degraded in 15 hr at this water to heavy oil ratio of 1.5 when the concentration of pyridine in heavy oil was 700 ppm and the cell concentration was 0.32 g DCW/L.
  Biotechnology and Bioprocess Engineering 04/1999; 4(3):205-209. · 1.28 Impact Factor