O. V. Sukhoveeva

Publications (2)0.29 Total impact

• Article: Effects of guanidine derivatives on the activities of superoxide dismutase and catalase during postischemic reperfusion in the rat brain

  A. V. Makeeva, T. N. Popova, O. V. Sukhoveeva, L. F. Panchenko
  [show abstract] [hide abstract]
  ABSTRACT: We studied the effects of guanidine derivatives on the activity of superoxide dismutase and catalase in the brain tissue and blood serum of rats after cerebral ischemia-reperfusion. We found that treatment with N-[imino(1-piperidinyl)methyl]guanidine or N-[imino(4-morpholinyl)methyl]guanidine resulted in normalization of the level of the primary products of lipid peroxidation, which was increased after brain pathology. Specific activities of superoxide dismutase and catalase were elevated in the brain and blood serum in animals that were subjected to ischemia-reperfusion. Administration of guanidine derivatives during ischemiareperfusion decreased the specific activities of both enzymes. Our data demonstrate that the investigated substances can play a neuroprotective role during ischemia-reperfusion and correct the antioxidant system of the body. Key wordsbrain-ischemia-reperfusion-guanidine derivatives-antioxidants-free radical oxidation
  Neurochemical Journal 04/2012; 4(3):217-221. · 0.29 Impact Factor
• Article: [The influence of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine on citrate content, aconitase and citrate synthase activities at ischemia-reperfusion of rats brain].

  O V Sukhoveeva, T N Popova, A V Makeeva, I Iu Iskusnykh
  [show abstract] [hide abstract]
  ABSTRACT: The influence of some guanidine derivatives on the level of brain citrate, brain activities of aconitase and citrate synthase has been investigated in rats subjected to ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Treatment with these compounds also decreased the degree of DNA fragmentation markedly increased in rats with ischemia-reperfusion.
  Biomedit͡sinskai͡a khimii͡a. 57(5):519-25.