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ABSTRACT: Discovered roughly 10 yr ago, Jak2 tyrosine kinase has emerged as a critical molecule in mammalian development, physiology,
and disease. Here, we review the early history of Jak2 and its role in health and disease. We will also review, its critical
role in mediating cytokine-dependent signal transduction. Additionally, more recent work demonstrating the importance of Jak2
in G protein-coupled receptor and tyrosine kinase growth factor receptor signal transduction will be discussed. The cellular
and biochemical mechanisms by which Jak2 tyrosine kinase is activated and regulated within the cell also will be reviewed.
Finally, structure-function and pharmacological-based studies that identified structural motifs and amino acids within Jak2
that are critical for its function will be examined. By reviewing the biology of Jak2 tyrosine kinase at the molecular. cellular,
and physiological levels, we hope to advance the understanding of how a single gene can have such a profound impact on development,
physiology, and disease.
Cell Biochemistry and Biophysics 41(2):207-231. · 1.91 Impact Factor