Zhiyin Yang

Jining Medical University, Chi-ning-shih, Shandong Sheng, China

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Publications (3)0.14 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: To study the effect of special brain area regional cerebral blood flow (rCBF) abnormal perfusion on learning and memory function and its molecular mechanism, 64 adult male healthy Sprague-Dawley (SD) rats were randomly divided into two groups, the false operation group (control group) and the operation group (model group). After surgical operation, the operation group undertook bilateral common carotid artery permanent ligation, while the other group did not. Learning and memory function were measured by Y-maze at 4 h, 8 h, 24 h and 3 d after surgical operation, respectively. The rCBF of the right frontal lobe and hippocampus was also detected by the PerifluxPF model laser Doppler flowmetry, and the expressions of c-fos or c-jun or Bcl-2 and Bax were also measured by immune histochemistry S-P method accordingly. Results showed that the rCBF of the right frontal lobe and hippocampus in the operation group was significantly lower than that in the false operation group (P < 0.05). The learning indexes, error number (EN), day of reach standard and total reaction time (TRT) in the operation group, were significantly higher than that in the false operation group (P < 0.05). However, the initiative evasion rate in the operation group was significantly lower than that in the false operation group. The study also found that the rCBF was relatively more, the indexes (EN, the day of reach standard and TRT) relatively fewer, but the initiative evasion rate and the memory keeping rate were relatively more. The positive expression and the average absorbency of Fos and Jun in the operation group were significantly higher than that in the false operation group (P < 0.05). Furthermore, Bax and Bcl-2 positive cells were all increased over time in the operation group, and the expression ratio of Bax/Bcl-2 in the operation group was significantly higher than that in the false operation group (P < 0.01). In conclusion, rCBF decrease can impair the learning and memory function in rats, which may be related to the increase of the expression ratio of c-fos or c-jun or Bcl-2 or Bax in the frontal cortex and hippocampus.
    Frontiers of Biology in China 01/2008; 3(2):147-153.
  • Lingbin Kong, Rui An, Zhiyin Yang
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    ABSTRACT: Background Presently, clinic memory scale is used to evaluate learning memory ability in most studies, and the influence of difference in measurement condition of individuals exists.Objective To study the correlation between regional cerebral blood flow (rCBF) perfusion and learning memory function in special brain regions of patients with cerebral infarction at convalescent period, and to try to find out a method which can quantitatively evaluate learning ability.DesignCase observation, and correlation analysis.SettingsShandong Institute for Behavioral Medicine; the Affiliated Hospital of Jining Medical College.ParticipantsTotally 70 patients with cerebral infarction admitted to Department of Neurology, Jining Medical College between January 2004 and December 2005 were involved. The involved patients, 58 male and 12 female, were averaged (52±3)years, and they were all right handed. They all met the diagnosis criteria instituted by the Fourth National Conference on Cerebrovascular Disease, and were confirmed as cerebral infarction by skull CT or MRI. Informed consents of detected items were obtained from all the patients and relatives.Methods When the patients were at convalescent period, their learning and memory ability were measured with “clinic memory scale (set A)”. The 18 patients whose total mark over 100 were regarded as good learning memory function group; The 23 cases whose total mark less than 70 were regarded as poor learning memory function group. RCBF of hippocampus, nucleus amygdalae, temporal cortex and prefrontal lobe of patients between two groups were measured and compared by single photon emission computed tomography (SPECT). The total scores of the 18 good learning memory patients and 23 poor learning memory patients were taken as dependent variable Y, and their rCBFs of hippocampus, nucleus amygdale, temporal cortex and prefrontal lobe respectively as independent variable X for linear correlation analysis.Main outcome measuresCorrelation of rCBF in different brain regions and learning memory ability in patients with cerebral infarction.Results The rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex of good learning memory function group were significantly higher than those of poor learning memory function group (P < 0.05). In the good learning memory function group, rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex were significantly positively correlated with memory scale scores(r = 0.961, 0.926, 0.954, 0.907, P < 0.05), and also in the poor learning memory function group (r = 0.979, 0.976, 0.991, 0.953, P < 0.05).Conclusion The rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex of patients with cerebral infarction are significantly positively correlated with memory scale scores. Predicting learning memory ability of patients by quantitative determination of rCBF provides a quantitative and objective method for evaluating learning memory ability.
    Neural Regeneration Research 08/2007; 2(8):461–465. · 0.14 Impact Factor
  • Lingbin Kong, Rui An, Zhiyin Yang
    [Show abstract] [Hide abstract]
    ABSTRACT: Background Presently, clinic memory scale is used to evaluate learning memory ability in most studies, and the influence of difference in measurement condition of individuals exists.
    Neural Regeneration Research - NEURAL REGEN RES. 01/2007; 2(8):461-465.