ABSTRACT: Essential hypertension, particularly systolic hypertension, can be characterized as a disorder of aging. The diverse expressions
of this disorder represent the interactions of a genetic script, the environment, chance, and a temporal factor. The temporal
factor, namely the telomeres, is biological, intrinsic, and dynamic. Telomere length is heritable, is inversely related to
pulse pressure, and can be modified by reactive oxygen species. The incorporation of a temporal factor into models of essential
hypertension may provide a heretofore missing link explaining variations in age-dependent increase in pulse pressure.
Current Hypertension Reports 04/2012; 3(1):33-35. · 2.50 Impact Factor