Zoltán Aigner

Publications (3)5.66 Total impact

• Article: Improvement of the Physicochemical Properties of Clotrimazole by Cyclodextrin Complexation

  Filiz Taneri, Tamer Guneri, Zoltán Aigner, Istráu Erös, Michael Kata
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  ABSTRACT: Complex formation between CDs and a very poorly water-soluble antifungal agent, clotrimazole (CLT), was studied. Products containing -CD were prepared in two molecular ratios by four methods. The rates of dissolution ofthe 1 : 1 drug/CD combinations revealed better dissolution properties than thoseof the 1 : 2 products. Drug/CD interactions in both aqueous solution and the solidstate were studied by phase solubility and thermal analysis. The effects of differentauxiliary materials (polymers, hydroxy acids and surfactants) on the aqueous solubilityof CLT were investigated. The aqueous solubility of CLT was increased significantly bythe addition of the auxiliary materials. Particle size distribution, partition coefficient,surface tension, heat of dissolution and wettability studies were also carried out.
  Journal of Inclusion Phenomena 01/2003; 46(1):1-13. · 1.89 Impact Factor
• Article: Increasing the solubility characteristics of fenofibrate with cyclodextrin

  Zoltán Aigner, Ingrid Bencz, Michael Kata
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  ABSTRACT: The incidence of genetic lipoprotein disorders, or hyperlipoproteinaemia, is currently increasing. Examinations were carried out on the hyperlipoproteinaemic drug fenofibrate and various cyclodextrin derivatives were applied to increase the solubility of this drug. Numerous products with several compositions (drug: CD mole ratio=2:1, 1:1, 1:2 or 1:3) were studied and three preparation methods (powder mixing, kneading and precipitation) were used. In vitro drug liberation and membrane diffusion examinations revealed compositions suitable for the preparation of a capsule dosage form (1:2 and 1:3 physical mixtures).
  Journal of Inclusion Phenomena 01/1994; 20(3):241-252. · 1.89 Impact Factor
• Article: Increasing the solubility characteristics of iomeglamic acid withβ-cyclodextrin

  Michael Kata, Zoltán Aigner, Piroska Révész, Béla Selmeczi
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  ABSTRACT: Iomeglamic acid has been successfully applied for radioscopy of the gall-bladder since 1972. This pharmacon has the disadvantageous property that it is practically insoluble in water. Preparations containing the drug in different concentrations were made with-cyclodextrin by different methods, and their dissolution characteristics were determined. In the best situation the solubility increased ten-fold. The tablets were made from the most suitable complex, with-cyclodextrin. The conditions of tableting, the parameters and the dissolution of the tablets were tested.
  Journal of Inclusion Phenomena 01/1989; 7(3):289-299. · 1.89 Impact Factor