Alexander Bürkle

Publications (1)0 Total impact

• Chapter: PARP-2: Structure-Function Relationship

  Valérie Schreiber, Michelle Ricoul, Jean-Christophe Amé, Françoise Dantzer, Véronique Meder, Catherine Spenlehauer, Patrick Stiegler, Claude Niedergang, Laure Sabatier, Vincent Favaudon, Josiane Ménissier-de Murcia, Gilbert de Murcia, Alexander Bürkle
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  ABSTRACT: Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity is immediately stimulated by DNA strand-breaks. This review summarizes our present knowledge of the structure and function of PARP-2, the closest relative to PARP-1.
  01/2008: pages 13-31;