Publications (1)0 Total impact
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Mitsuko Furuya
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ABSTRACT: Vasculogenesis and angiogenesis are critical events in embryogenesis, tissue remodeling and pathological conditions including
tumor progression. Solid tumors require blood supply for their growth, and tumor blood vessels generally sprout from preexisting
vascular cells. In addition, various types of precursor cells also participate in tumor angiogenesis. They include endothelial
progenitor cells, hematopoietic stem cells and mesenchymal stem cells that are stimulated and attracted into tumor lesion.
Recent studies of tumor microenvironment have disclosed that bone marrow (BM)-derived progenitor cells contain unique subpopulations
that do not become fully-differentiated vascular constituents; instead, they show the nature of immature myeloid or mesenchymal
lineage, and they enhance tumor angiogenic milieu in close contact with tumor vessels. BM-derived cells also migrate into
pre-metastatic niche and stimulate vascular beds of distant organ where they attract circulating tumor cells by secreting
various bioactive substances. In this chapter, the complexity of tumor angiogenesis and tumor proinflammatory microenvironment
are discussed, with an emphasis on vascular constituent cells.
KeywordsTumor-Angiogenesis-Vasculogenesis-Metastasis-Stem cells-Chemokines
12/2011: pages 13-20;
