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ABSTRACT: Pressure overload of the heart is associated with a perturbed gene expression of the cardiomyocyte leading to an impaired pump function. The ensuing neuro-endocrine activation results in disordered influences of angiotensin II and catecholamines on gene expression. To assess whether angiotensin II type 1 receptor inhibition can also counteract a raised sympathetic nervous system activity, spontaneously hypertensive rats fed a hypercaloric diet were treated with eprosartan (daily 90 mg/kg body wt) and cardiovascular parameters were monitored with implanted radiotelemetry pressure transducers. Both, blood pressure and heart rate were increased (p < 0.05)="" by="" the="" hypercaloric="" diet.="" although="" eprosartan="" reduced="" (p="">< 0.05)="" the="" raised="" systolic="" and="" diastolic="" blood="" pressure,="" the="" diet-induced="" rise="" in="" heart="" rate="" was="" blunted="" only="" partially.="" in="" addition="" to="" drugs="" interfering="" with="" the="" enhanced="" catecholamine="" influence,="" compounds="" should="" be="" considered="" that="" selectively="" affect="" cardiomyocyte="" gene="" expression="" via="" 'metabolic'="">
Molecular and Cellular Biochemistry 08/2000; 212(1):135-142. · 2.06 Impact Factor
