ABSTRACT: A free-ranging, adult, male Persian leopard (Panthera pardus ciscaucasica) was found at Geloul-Sarani protected zone, province of North-Khorasan, Iran and transported to the Ferdowsi University of Mashhad Veterinary Teaching Hospital. The leopard had normal temperature and respiratory and cardiac frequency, but was significantly dehydrated and had elevated capillary perfusion. The animal also was cachectic, with pale mucus membranes, third-eyelid protrusion, and bilaterally enlarged submandibular lymph nodes. The leopard was stabilized by intensive fluid and electrolyte therapy and hospitalized. In 2 days, the leopard had improved clinically but had severe ataxia and head pressing. Blood smears revealed gamonts of Hepatozoon sp. within some neutrophils. Hematologic and plasma chemistry abnormalities included moderate anemia, leukocytosis, hypocholestrolemia, and hypophosphatemia. In radiographic evaluations, no sign of periosteal reactions or new bone formation was seen on the skull, spine, long bones, pelvis, or vertebrae. The leopard was treated successfully with Tazocin and clindamycin for 1 mo. This is the first detection of a Hepatozoon sp. in wild Felidae in Iran. Because most Iranian wild felids and canids are endangered, knowing whether Hepatozoon infection represents a threat for these animals is important.
Journal of wildlife diseases 07/2012; 48(3):776-80. · 1.08 Impact Factor
ABSTRACT: The use of non-steroidal anti-inflammatory drugs (NSAIDs) can be associated with severe adverse effects. The aim of this experimental
study was to investigate the effect of piroxicam and ketoprofen, two NSAIDs with different excretion pathways, on the gastric
mucosa, kidney, liver, and hematopoietic system of dogs. Fifteen mixed-breed healthy dogs of both sexes aged between 1 to
8years were randomly divided in three groups and treated with piroxicam (0.15mg/kg intramuscularly (IM)), ketoprofen (1mg/kg
IM) or placebo daily for 21days. Although not statistically significant (p > 0.05), the dogs receiving ketoprofen showed fewer and less severe lesions than the dogs in the piroxicam group. None of
the dogs showed any clinical signs related to the gastric lesions. Serum biochemical and complete blood count parameters did
not change significantly after NSAlD administration (p > 0.05). However, by day 14, a decreased number of platelets and prolonged bleeding time were detected in treatment groups
compared with the control group (p < 0.05). The clinical significance of this prolongation is unclear. This study suggests that ketoprofen and piroxicam produce
mild lesions when administered to healthy dogs for 21days, and there is no difference between the two groups in the number
and severity of lesions. There may be an indication that longer duration of drug administration may result in a greater number
of gastric lesions. However, after long-term NSAID exposure (21days in our study), gastric tolerance to the damage caused
by NSAIDs will be developed.
KeywordsNon-steroidal anti-inflammatory drugs–Gastric lesions–Piroxicam–Ketoprofen–Dog
Comparative Clinical Pathology 04/2012; 20(1):65-68.
ABSTRACT: An 11-year-old male dog was presented with a 1-week history of inappetence, weight loss and hind limb paralysis. Physical
examination revealed weakness, depression, incoordination of the posterior limbs, peripheral lymphadenopathy and pale mucous
membranes. Laboratory analysis of blood samples revealed anaemia, thrombocytopenia and low serum albumin concentration. The
diagnosis was confirmed microscopically, by demonstrating the presence of Hepatozoon canis gametocytes within neutrophils in Giemsa-stained peripheral blood smears and bone marrow smear. Also, schizonts of H. canis were seen in tissue sections of muscles, lymph nodes, spleen and liver. To the best of authors’ knowledge, this is the first
description of H. canis infection in a dog in Iran.
Comparative Clinical Pathology 04/2012; 18(4):455-458.