ABSTRACT: Objective: To observe the clinical effect of Modified Taohong Siwu Decoction (MTSD) in treating pediatric intractable nephropathy (PIN).Methods: Ninety-five patients with PIN were divided into 2 groups at random. The 60 patients in the treated group were treated with
MTSD and the 35 patients in the control group were treated with heparin. The clinical therapeutic effect and levels of thromboxane
B2(TXB2) and 6-keto-prostacyclin Fla(6-keto-PGFla) before and after treatment were observed. Results: The total effective rate in the treated group was 81.7%, which was similar
to that in the control group (80.0%,P > 0.05). The levels of TXB2 and TXB2/6-keto-PGFla ratio were higher in both groups of the patients as compared with those of the healthy control (P<0.01). After treatment, the two criteria were significantly improved in the two treated groups, as compared with those before
treatment, the difference was significant (P<0.01), while in comparison between the MTSD treated group and the control group, no significant difference was found (P >0. 05).Conclusion: MTSD has good effect in treating PIN, it could improve the metabolic unbalance of thromboxane and prostacyclin.
Chinese Journal of Integrative Medicine 04/2012; 7(2):94-98. · 0.80 Impact Factor