ABSTRACT: The purpose of this case control study was to evaluate the role of X-ray repair cross-complementing group 1 (XRCC1) and xeroderma
pigmentosum group D (XPD) genotypes as genetic indicators of susceptibility to breast cancer (BC). We analysed DNA samples
from 114 breast cancer patients and 113 control subjects using polymerase chain reaction–restriction fragment length polymorphism.
For the single nucleotide polymorphisms in XRCC1 exon 10 (Arg399Gln, G/A) and XPD exon 23 (Lys751Gln, A/C), no remarkable
differences for genotype distribution and allele frequencies were observed between BC group and control group in the study.
The genotype frequency for homozygote A/A in XPD exon 6 (Arg156Arg, C/A) were significantly different between BC and control
groups (P < 0.0001, odds ratio = 2.14; 95% confidence interval 1.44–3.17). The data indicate a possible role for XPD (Arg156Arg, C/A) polymorphisms in BC susceptibility.
Pathology & Oncology Research 04/2012; 14(2):131-135. · 1.37 Impact Factor