Leonardo Glutz von Blotzheim

University of Zurich, Zürich, ZH, Switzerland

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Publications (3)4.3 Total impact

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    ABSTRACT: Martorell hypertensive ischemic leg ulcer (Martorell ulcer) is characterized by distinct alterations in the arteriolar wall of subcutaneous vessels, leading to progressive narrowing of the vascular lumen and increase of vascular resistance. These changes are similar to the alterations observed in pulmonary arterioles in patients with chronic pulmonary hypertension (PH). This study was aimed to assess an association between the two disorders. In this case-control study, 14 patients with Martorell ulcer were clinically assessed for the presence of pulmonary hypertension using transthoracic Doppler echocardiography. Data from patients were compared to 28 matched hypertensive controls. Systolic pulmonary arterial pressure (sPAP) in patients with Martorell ulcer was significantly higher than in the control group (33.8 ± 16.9 vs 25.3 ± 6.5 mmHg, p = 0.023); the prevalence of pulmonary hypertension was 31% (5/14) in patients and 7% (2/28) in controls (p = 0.031). No differences were seen in left heart size and function between patients and controls. This study provides first evidence that subcutaneous arteriolosclerosis, the hallmark of Martorell ulcer, is associated with PH. These findings suggest that patients with Martorell leg ulcer might be at significant risk to develop elevated pulmonary arterial pressure. Patients with leg ulcers who present with dyspnea should be evaluated by echocardiography for the presence of pulmonary hypertension.
    Respiratory research 06/2012; 13:45. · 3.64 Impact Factor
  • L Glutz von Blotzheim, N J Müller, L C Huber, T Degen
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    ABSTRACT: We report the case of a 76-year-old female patient presenting with deep venous thrombosis and upper cervical lymphadenopathy. A computed tomography (CT) scan showed multiple hepatic lesions with a high suspicion of metastatic disease from an unknown primary tumor. The differential diagnosis of lymphadenopathy and hepatic lesions includes malignant tumors and various infectious diseases. The diagnostic process, however, revealed lymph node tuberculosis with multiple hepatic granulomas despite a repeatedly negative interferon-γ release assay. A combined antituberculosis therapy led to complete clinical remission.
    Der Internist 04/2012; 53(6):756-9. · 0.33 Impact Factor
  • L. Glutz von Blotzheim, N.J. Müller, L.C. Huber, T. Degen
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    ABSTRACT: Wir berichten über den Fall einer 76-jährigen Patientin, die sich mit einer tiefen Beinvenenthrombose und zervikaler Lymphadenopathie präsentierte. Computertomographisch bestand der Verdacht auf multiple Lebermetastasen bei unklarem Primärtumor. Die Differenzialdiagnose von Lymphadenopathie und Leberläsionen ist breit und beinhaltet u. a. maligne Prozesse sowie verschiedene infektiöse Ursachen. Die weiterführende Diagnostik zeigte das in unseren Breiten seltene Bild einer Lymphknotentuberkulose mit multiplen hepatischen Tuberkulomen bei wiederholt negativem Interferon-γ-release-Test. Unter kombinierter 4er-Therapie kam es im Verlauf zu einer kompletten Remission.
    Der Internist 53(6). · 0.33 Impact Factor