Lee Harland

Publications (2)6.63 Total impact

• Source

  Available from: Antony John Williams

  Article: Applying Linked Data Approaches to Pharmacology: Architectural Decisions and Implementation

  Alasdair J G Gray, Paul Groth, Antonis Loizou, Sune Askjaer, Christian Brenninkmeijer, Kees Burger, Christine Chichester, Chris T Evelo, Carole Goble, Lee Harland, Steve Pettifer, Mark Thompson, Andra Waagmeester, Antony J Williams
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  ABSTRACT: The discovery of new medicines requires pharmacologists to interact with a number of information sources ranging from tabular data to scientific papers, and other specialized formats. In this application report, we describe a linked data platform for integrating multiple pharmacology datasets that form the basis for several drug discovery applications. The functionality offered by the platform has been drawn from a collection of prioritised drug discovery business questions created as part of the Open PHACTS project, a collaboration of research institutions and major pharmaceutical companies. We describe the architec-ture of the platform focusing on seven design decisions that drove its development with the aim of informing others developing similar software in this or other domains. The utility of the platform is demonstrated by the variety of drug discovery applications being built to access the integrated data.
  Semantic Web – Interoperability, Usability, Applicability. 11/2012;
• Article: Open PHACTS: semantic interoperability for drug discovery.

  Antony J Williams, Lee Harland, Paul Groth, Stephen Pettifer, Christine Chichester, Egon L Willighagen, Chris T Evelo, Niklas Blomberg, Gerhard Ecker, Carole Goble, Barend Mons
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  ABSTRACT: Open PHACTS is a public-private partnership between academia, publishers, small and medium sized enterprises and pharmaceutical companies. The goal of the project is to deliver and sustain an 'open pharmacological space' using and enhancing state-of-the-art semantic web standards and technologies. It is focused on practical and robust applications to solve specific questions in drug discovery research. OPS is intended to facilitate improvements in drug discovery in academia and industry and to support open innovation and in-house non-public drug discovery research. This paper lays out the challenges and how the Open PHACTS project is hoping to address these challenges technically and socially.
  Drug discovery today 06/2012; · 6.63 Impact Factor