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ABSTRACT: In this paper we present a series of experiments showing that vertical self-assembled diphenylalanine
peptide nanowires (PNWs) are a suitable candidate material for cellular biosensing. We grew
HeLa and PC12 cells onto PNW modified gold surfaces and observed no hindrance of cell
growth caused by the peptide nanostructures; furthermore we studied the properties of PNWs by
investigating their influence on the electrochemical behavior of gold electrodes. The PNWs were
functionalized with polypyrrole (PPy) by chemical polymerization, therefore creating conducting peptide/
polymer nanowire structures vertically attached to a metal electrode. The electroactivity of such
structures was characterized by cyclic voltammetry. The PNW/PPy modified electrodes were finally
used as amperometric dopamine sensors, yielding a detection limit of 3,1 µM
Journal of Nanoscience and Nanotechnology 06/2012; 12:3077-3083. · 1.56 Impact Factor
