Sema Sirma Ekmekci,
Cumhur G Ekmekci,
Ayten Kandilci,
Cagri Gulec,
Meral Akbiyik,
Zeliha Emrence,
Neslihan Abaci,
Zeynep Karakas,
Leyla Agaoglu,
Aysegul Unuvar,
Sema Anak,
Omer Devecioglu,
Duran Ustek, Gerard Grosveld,
Ugur Ozbek
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ABSTRACT: The SET gene is a target of chromosomal translocations in acute leukemia and encodes a widely expressed multifunctional phosphoprotein. It has been shown that SET is upregulated in BCR-ABL1-positive cell lines, patient-derived chronic myeloid leukemia CD34-positive cells, and some solid tumors.
We determined the expression level of SET in 59 pediatric acute lymphoblastic leukemia patients who were BCR-ABL-negative using quantitative real-time reverse-transcriptase-polymerase chain reaction. Results. We showed that SET expression was significantly upregulated in 96.5% of B-acute lymphoblastic leukemia (28 of 29; 16.6 fold) and 93% of T-acute lymphoblastic leukemia (28 of 30; 47.6 fold) patients. This upregulation was not associated with any clinical features or overall and relapse-free survival.
Our results showed that SET is significantly overexpressed in pediatric acute lymphoblastic leukemia samples, and an increased level of SET might contribute to leukemic process.
Tumori. 03/2012; 98(2):252-6.
