Selcen Odyakmaz

Ondokuz Mayıs Üniversitesi, Samsun, Samsun, Turkey

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Publications (5)3.03 Total impact

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    ABSTRACT: To compare circulating and gingival crevicular fluid (GCF) substance P concentrations in well- and poorly controlled type 2 diabetic patients with chronic periodontitis. Forty-five serum and 90 GCF samples were collected from diabetic patients with periodontal disease, and the concentrations of substance P were quantified by radioimmunoassay. Serum substance P levels were higher in the poorly controlled diabetic group than in patients with good glycemic control (P = .01); within the poorly controlled group, patients with severe attachment levels had the highest circulating substance P levels (P = .02). Additionally, the diseased sites showed higher substance P levels than control sites (P = .0016). The GCF substance P concentrations in diseased sites correlated significantly with clinical findings such as Plaque Index (r = 0.51, P = .001) and bleeding on probing (r = 0.35, P = .029). Within the limits of this study, our preliminary findings indicate that periodontal inflammation may influence circulating and GCF substance P levels in poorly controlled diabetic subjects.
    Quintessence international (Berlin, Germany: 1985) 06/2012; 43(7):587-96. · 0.64 Impact Factor
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    ABSTRACT: Objective: This study investigated the impact of diabetes on periodontal inflammatory response in relation to metabolic control status of diabetes by revealing any alterations in the inducible nitric-oxide synthase (iNOS), interleukin 1beta(IL-1beta), tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) levels of gingiva in diabetic and non-diabetic patients with and/or without chronic periodontitis. Methods: The study was performed on 118 male, adult and non-smoker individuals without another systemic disorder according to their diabetic and periodontal conditions, i.e. 20 non-diabetic subjects with periodontitis (group 1), 20 non-diabetic subjects without periodontitis (group 2), 20 uncontrolled diabetic subjects (HbA1c>7) with periodontitis (group 3), 20 controlled diabetic subjects (HbA1c≤7) with periodontitis (group 4), 20 controlled diabetic subjects (HbA1c≤7) without periodontitis (group 5) and 18 uncontrolled diabetic subjects (HbA1c>7) without periodontitis (group 6) constituted the study groups. One tooth site per subject providing the group criteria were utilized for gingival biopsy collection in each group, and gingival iNOS, IL-1beta, TNF-alpha and IFN-gamma levels were detected by ELISA in the supernatants of these biopsy samples. Data were analysed by ANOVA and Post-Hoc Tukey tests for the statistics. Results: iNOS was highest in group 3 and lowest in group 2 (3>1-4>6>5-2) (p<0.05). IL-1beta was highest in group 1 and lowest in group 5 (1-3>4>6-2-5) (p<0.05). TNF-alpha demonstrated differences between group 3 and groups 1,2,4,5,6 and between group 1 and groups 2,5 (3>1-4-6-2-5 and 1>2-5) (p<0.05). IFN- gamma demonstrated differences between group 3 and groups 1,2,4,5,6 and between groups 1,4 and groups 2,5,6 (3>4-1-2-6-5 and 4-1>2-6-5) (p<0.05). Conclusion: The results suggest that: (i) metabolic control status of diabetes may not affect and/or induce periodontal inflammatory response on healthy periodontium, (ii) uncontrolled diabetes may intensify an existing periodontitis and (iii) metabolic control of diabetes in periodontitis may elicit similar periodontal inflammatory response with that of non-diabetic conditions.
    IADR General Session 2010; 07/2010
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    Emin Murat Canger, Peruze Celenk, Murat Yenísey, Selcen Zeynep Odyakmaz
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    ABSTRACT: Amelogenesis imperfecta (AI) is a hereditary disorder expressing a group of conditions that cause developmental alterations in the structure of enamel. AI is a serious problem that reduces oral health-related quality of life and causes some physiological problems. The treatment of patients with AI may upgrade the quality of life and reinforce their self-esteem. Among the treatment options for AI, full-mouth metal reinforced porcelain restoration constitutes an important alternative because of its properties. This paper presents a case of AI of the hypoplastic rough type associated with a group of dental anomalies, and describes the prosthetic management of the patient. A 26-year-old female patient presented with a chief complaint of discolored teeth. Clinical and radiographic examination of the patient confirmed the diagnosis of rough pattern hypoplastic AI. The patient was treated with full-mouth metal reinforced porcelain fixed bridge. The adaptation of the temporomandibular joints and masticatory muscles was carefully observed periodically during 4 months and, after this period, the patient tolerated well her new vertical dimension. The patient received instructions on cleansing of the subpontic and interproximal areas. Follow-up visits were scheduled at 3 months and then at 6 months. No esthetic or functional problems were seen after the follow up period.
    Brazilian dental journal 01/2010; 21(2):170-4.
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    ABSTRACT: The present study aimed to investigate the local peptidergic innervation of diseased and healthy periodontia in smokers and non-smokers. Fifteen smokers and 12 non-smokers, all with localized chronic periodontitis, participated in the study. Periodontally diseased and healthy tooth sites were selected in smokers (groups 1 and 2, respectively) and non-smokers (groups 3 and 4, respectively). Local peptidergic innervation was assessed by the concentrations of two neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP), in the gingival biopsies obtained from the groups. Clinical data and biopsies were collected from the same two tooth sites in each group. SP and CGRP levels were measured by enzyme immunosorbent assay in the supernatants of gingival samples. Increased probing depth and attachment loss were found in group 1 compared to group 3 (P<0.05). SP was higher in group 1 compared to groups 2, 3, and 4, and it was higher in group 3 compared to groups 2 and 4 (P<0.05). CGRP was higher in group 1 than in groups 2, 3, and 4, but it was lower in group 3 than in groups 2 and 4 (P<0.05). The study results suggested that 1) although smoking may affect the neurogenic inflammation in the presence of periodontitis by increasing local peptidergic innervation, this effect may not be seen in periodontal health, and 2) SP may be regarded as an indicator of periodontitis, whereas CGRP may be important in the acute and/or initial periodontal inflammation.
    Journal of Periodontology 08/2008; 79(8):1451-6. · 2.40 Impact Factor
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    ABSTRACT: Tooth loss may be considered as a tragic end-point resulted from periodontal disease. In other words, tooth loss may be described as the failure of a periodontal treatment. Therefore, revealing the conditions preparing this outcome may be important in the strategical peridontal treatment planning. There are a lot of investigations which have docu- mented the local, systemic and/or environmental factors influencing the tooth loss due to periodontitis. In most of these investigations, microbial dental plaque and dental history, age, gender, marital status, smoking and attachment loss in 4 or more teeth in the mouth have been consented to be the major local and/or environmental factors which have positive and predictive effects on future tooth loss (1-3). However, the studies which have investigated the effects of systemic diseases on periodontal tooth loss generally focus on observing the amounts of periodontal tooth loss in a single systemic disease group, and the results of these studies have revealed a one-to-one relationship