Jairo Fonseca

National University of Colombia, Μπογκοτά, Bogota D.C., Colombia

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Publications (6)2.52 Total impact

  • Source
    XXI Congreso Latinoamericano de Parasitología- FLAP 2013; 10/2013
  • XXI Congreso Latinoamericano de Parasitología- FLAP 2013, Guayaquíl- Ecuador. Octubre 2013; 10/2013
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    ABSTRACT: During the last decade Entamoeba moshkovskii has become relevant given its capacity to infect humans, especially when considering that it is morphologically indistinguishable from E. histolytica. For a long time, E. moshkovskii was considered as a free living amoeba, but in the last decade it has been demonstrated that E. moshkovskii can infect humans and can be found more frequently in regions where amebiasis shows high prevalence values, becoming a challenge to differentiate it from the E. histolytica/E. dispar complex. Recently there have been studies that raise the possibility that E. moshkovskii could be a pathogenic species, as there are reports in different countries that associated this infection with gastrointestinal symptoms even though others have described it as a non pathogenic species. For this reasons, both clinical and epidemiological studies are required.
    Acta tropica 06/2012; 123(3):139-45. DOI:10.1016/j.actatropica.2012.05.012 · 2.52 Impact Factor
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    Presencia de protozoos de importancia en salud pública en aguas residuales crudas y tratadas, del municipio El Rosal, Cundinamarca, Colombia, Bogotá; 09/2011
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    ABSTRACT: dhfr and dhps sulfadoxine/pyrimethamine (SP) resistance genotypes in P.falciparum populations exhibit sensitive or intermediate resistance genotypes west of the Colombian Andes while eastern populations in the Orinoco and Amazonas are of the intermediate or highly resistant genotypes. An analysis of previously published genotype data from Colombia and South America allow us to hypothesize, that the combined non-random association of dhfr and dhps genotypes circulating in the country are the reflection of the drug’s application history. Pyrimethamine resistance first developed in South America on a dhps sensitive background when pyrimethamine alone was introduced in the late 50s and early 60s. Subsequently, resistance to sulfadoxine appeared in the Amazon basin in the 1980s after the introduction of the SP combination. Given our previous results showing the single origin of all intermediate and highly resistant parasite populations in the country, we present a model whereby the dissemination of dhfr resistant/dhps sensitive genotypes across Colombian Andes most probably took place before the 1980s. After the introduction of SP, dhps resistance developed in the Amazon region; however, since genetic exchanges between eastern and western P.falciparum populations across the Andes is highly restricted to the Northwest and Orinoco populations and no or few genetic exchanges seem to take place between the Amazon and the West pacific region, the probability of disseminating the high resistance genotypes has been low, thus explaining the sensitivity to the SP drug combination in many places of the Colombian western Pacific region.
    59th Annual Meeting ASTMH (American Society of Tropical Medicine and Hygiene), Atlanta , Georgia, USA; 11/2010
  • [Show abstract] [Hide abstract]
    ABSTRACT: dhfr and dhps sulfadoxine/pyrimethamine (SP) resistance genotypes in P.falciparum populations exhibit sensitive or intermediate resistance genotypes west of the Colombian Andes while eastern populations in the Orinoco and Amazonas are of the intermediate or highly resistant genotypes. An analysis of previously published genotype data from Colombia and South America allow us to hypothesize, that the combined non-random association of dhfr and dhps genotypes circulating in the country are the reflection of the drug’s application history. Pyrimethamine resistance first developed in South America on a dhps sensitive background when pyrimethamine alone was introduced in the late 50s and early 60s. Subsequently, resistance to sulfadoxine appeared in the Amazon basin in the 1980s after the introduction of the SP combination. Given our previous results showing the single origin of all intermediate and highly resistant parasite populations in the country, we present a model whereby the dissemination of dhfr resistant/dhps sensitive genotypes across Colombian Andes most probably took place before the 1980s. After the introduction of SP, dhps resistance developed in the Amazon region; however, since genetic exchanges between eastern and western P.falciparum populations across the Andes is highly restricted to the Northwest and Orinoco populations and no or few genetic exchanges seem to take place between the Amazon and the West pacific region, the probability of disseminating the high resistance genotypes has been low, thus explaining the sensitivity to the SP drug combination in many places of the Colombian western Pacific region.
    59th Annual Meeting ASTMH (American Society of Tropical Medicine and Hygiene), Atlanta , Georgia USA; 11/2010