ABSTRACT: QuestionIn patients undergoing surgery, does prophylactic dimenhydrinate reduce the frequency of postoperative nausea and vomiting
(PONV) compared to placebo?
Data sourcesStudies were identified by computerized searches (MEDLINE, EMBASE, Cochrane Library) up to June 2001, citation review, and
hand searches of locally available anesthesia journals. No language restrictions were applied.
Study selectionStudies were selected if they were randomized controlled trials comparing prophylactic dimenhydrinate or diphenhydramine to
Data extractionData was extracted in duplicate on postoperative nausea, postoperative vomiting, and PONV.
Main resultsEighteen trials with a total of 3,045 patients met the inclusion criteria. Compared to placebo, dimenhydrinate reduced the
frequency of early (0–6 hr postoperatively) PONV (relative benefit [RB] 1.21; 95% confidence interval [CI] 1.07–1.21) and
overall (0–48 hr postoperatively) PONV (RB 1.51; 95% CI 1.27–1.78; Table). Dimenhydrinate reduced overall PONV in subgroups
of adults, children, and routes of administration (iv/im orpr).
ConclusionProphylactic dimenhydrinate reduces PONV up to 48 hr after surgery.
Canadian Journal of Anaesthesia 04/2012; 50(1):11-13. · 2.35 Impact Factor