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Publications (4)0.49 Total impact

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    ABSTRACT: Purpose/Objective(s): In this study, we aimed to evaluate the characteristics that effects on the survival rate and locoregional control for external beam radiotherapy(EBRT) in thyroid cancer retrospectively.Materials/Methods:Between January 2006 to December 2011, 57 patients with thyroid cancer treated with EBRT in our Institute. Median follow-up time for all patients was 17 months (range 4-73). Most patients in the present study had advanced or reccurent disease. Pathologic findings are differantiated in 28 patients (%51) anaplastic in14 patients(25%) and medullary carcinoma in 13 patients (24%). Fourty-two patients had surgery prior to radiotherapy(RT) and most of patients were performed total thyroidectomy (60%). After surgery 67% of patients received curative EBRT. The median dose was 60Gy with a range of 45-66Gy, once-daily fractionation. Three patients who did not receieved EBRT and 15 patients who received palliative RT were excluded from survival(OS) and locoregional control(LC) analysis.Results: LC rates were lower in the patients at older age than 45(p:0.01), anaplastic histology(p:0.01) and positive surgical margins(p:0.05) significantly. In univariate survival analysis, DFS at 3 years for ATC, DTC, MTC patients was 0%, 57%, 61% (p<001), for age <45, and ≥45 was 69%, 35% (p:006), for <T4 and T4 was 62,5%, 35% (p:0.05). In univariate survival analysis, cause-spesific OS at 3 years for ATC, DTC, MTC patients was 0%, 56%, 67% (p<001), retrospectively. Cox multiple regression analysis show that age, histogy, recurrence prior to RT were the statistically significant factors for DFS and age, histogy were the statistically significant factors for OS.Conclusions: The role of radiotherapy in thyroid cancer is controversial. Our results supports and expands most of the data reported till now for the use of EBRT in thyroid cancer.
    Radiological Society of North America 2013 Scientific Assembly and Annual Meeting; 12/2013
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    Oner Ozdemir, Rabia Dağoğlu, Azize Goksu Erol
    Polish journal of pathology: official journal of the Polish Society of Pathologists 12/2012; 63(4):292. · 0.49 Impact Factor
  • Rabia Nergiz Dagoglu
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    ABSTRACT: Purpose/Objective(s): Although the majority of clinical trials have shown that high grade prostate cancer patients treated with external radiotherapy (ERT) and androgen deprivation therapy (ADT) have a therapeutic advantage over those treated with ERT alone, molecular interactions between these modalities have not been well defined. In this study, the interaction between different doses of ERT and ADT is aimed to be evaluated by clonogenic assay, apoptosis and DNA methylation.Materials/Methods: LNCaP cells were evaluated in vitro in three different groups: 1) CM: complete medium, 2) SS: charcoal-stripped serum, 3) SS+Testosterone: testeosterone added medium. CM group was cultured in Bovine Serum Albumin medium. Androgen deprivation (AD) was achieved by culture in charcoal-stripped serum containning serum for SS group. SS+Testosterone group was a result of replacement of androgen was done by adding synthetic testeosterone. Each group was classified into four subgroups for external radiation application (ERA). Other thnn control groups, 2,3 and 5Gy doses were applied for each subgroup. Analysis was done by clonogenic assay, apoptosis and DNA methylation and the correlations between groups were evaluated with pair t testResults: SS group which had complete androgen deprivation showed significant different on clonojenic assay compared with the groups that underwent radiation and that did not. Adding testesteron presented increase in clonogenic asssay but the results did not reach the values of the control group. Comparing SS and SS+Testesterone groups according to the applied radiation doses, 2 Gy and 3Gy doses sis not point out a significant difference. On the other hand, 5Gy doses showed significant different between the two groups. Evaluating the apoptotic ratio, the differences among CM-SS, CM-SS+Testesterone and SS-SS+Testesteron were significant. The difference between SS and SS+Testesterone implied the supraadditive effect of androgen deprivation on apoptotic ratio. Evaluating the results for DNA methylation did not present a correlation among groupsConclusions: The results attribute to the supraadditive interaction between ADT and ERT is limited to apoptotic ratio but it is not expressed in clonogenic assay.DNA methylation could not be defined as areliable evaluation method for in vivo studies
    Radiological Society of North America 2012 Scientific Assembly and Annual Meeting; 11/2012
  • Rabia Nergiz Dağoğlu, Oner Ozdemir, Arzu Ergen, Fulya Yaman Ağaoğlu
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    ABSTRACT: Nasal extranodal natural killer/T-cell lymphoma, which is a highly aggressive disease, is more frequently seen in Asia than in Western countries. No consensus has been reached on the management of the disease and the survival depends on the stage of the disease. Localized NK/T-cell lymphoma often responds to radiotherapy well. However, patients with advanced disease or recurrence after chemoradiotherapy, similar to our patient, have a very poor prognosis. In this article, we present a 52-year-old male patient with early recurrence and who was refractory to chemotherapy. The management of the disease was reviewed in the light of the recent literature data.
    Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 22(3):164-71.