Hui Li

North China University of Water Conservancy and Electric Power, Cheng, Henan Sheng, China

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Publications (839)1659.23 Total impact

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    ABSTRACT: The interaction of drospirenone (DP) with human serum albumin (HSA)/lysozyme (LYZ) was investigated using different optical techniques and molecular models. Results from the emission and time resolved fluorescence studies revealed that HSA/LYZ emission quenching with DP was initiated by static quenching mechanism. The LYZ-DP system was more easily influenced by temperature than the HSA-DP system. Displacement experiments demonstrated that the DP binding site was mainly located in site 1 of HSA. Based on the docking methods, DP was mainly bound in the active site hinge region where Trp-62 and Trp-63 are located. Conformation study showed that DP had different effects on the local conformation of HSA and LYZ molecules.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 01/2016; 153:612-618. DOI:10.1016/j.saa.2015.09.017 · 2.35 Impact Factor
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    Hui Li · Qiangqiang Zhang · Huigang Xiao ·
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    ABSTRACT: A carbon nano-fiber based conductive polymer (CNFP) film was fabricated by multi-scale carbon nano-fibers (10 ~ 200 nm) an in-situ filtrating casting process, due to the well-connected hierarchical microstructures and strong-wrapped assembling among carbon nano-fibers, the as-prepared CNFP presents excellent electrical conductivity, high thermo-electric performance and good mechanical properties. And the resistivity of the CNFP exhibited piecewise linear temperature-dependent characteristics within a certain temperature range (0 ~ 280 °C). Furthermore, based on excellent electric and thermo-electric properties, CNFP was employed as electric heating element to develop a novel self-deicing road system. This CNFP-based deicing system is consisted of CNFP as thermal source, an AlN-ceramic insulated encapsulation layer, a multiwall carbon nanotube (MWCNT)/cement-based thermal conduction layer and a thermally insulated substrate. Additionally, the MWCNT/cement-based composite, which was filled with 3% by weight MWCNT, was proposed as the thermal conduction layer because its thermal conduction properties are superior to those of cement with other fillers and to those of common cement-based composites. To ensure the efficient operation of the CNFP, an AlN-ceramic wafer (0.5 mm) was employed as the electro-insulated layer because of its favorable insulating and thermo-conductive properties. The constructed system was applied in deicing and field snow-thawing studies, in which the effects of ambient temperature, heat flux density and ice thickness on the deicing and snow-thawing performance of the self-deicing system were investigated. The efficiency, repeatability, cost and feasibility of the self-deicing road system in both deicing and snow-thawing applications were analyzed. Indices for evaluating the deicing or snow-thawing performance of the self-deicing road system were proposed and the optimal values for each parameter are presented. The results demonstrate the promise of CNFP as heating element of self-heating pavement on a wide application in deicing or snow-thawing for infrastructures, including pavement, highway, airport and bridge.
    Innovative Developments of Advanced Multifunctional Nanocomposites in Civil and Structural Engineering, Edited by K.J. Loh, S. Nagarajaiah, 01/2016: chapter Chapter 10; Woodhead Publishing: Cambridge, England.
  • Di Wu · Jin Yan · Peixiao Tang · Shanshan Li · Kailin Xu · Hui Li ·
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    ABSTRACT: Considering the harmful impact of food antioxidants on human bodies, thoroughly exposing their potential effects at the molecular level is important. In this study, the binding interactions of butylated hydroxyanisole (BHA), a phenolic antioxidant, and its different major metabolites tert-butylhydroquinone (TBHQ) and tert-butylbenzoquinone (TBQ) with lysozyme were examined via fluorescence, three-dimensional fluorescence, circular dichroism (CD), and ligand-protein docking studies. The three compounds caused strong quenching of lysozyme fluorescence by a static quenching mechanism but with different quenching efficiencies and different effects on the α-helix content of the lysozyme. The order of binding affinity of lysozyme for all test compounds is as follows: BHA>TBQ>TBHQ. Thermodynamic parameters indicated that hydrogen bonding and van der Waals forces perform dominant functions in the binding between these compounds and lysozyme. Furthermore, structure-affinity relationships between the model compounds and lysozyme were established on the basis of computational analyses. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Food Chemistry 12/2015; 188. DOI:10.1016/j.foodchem.2015.05.013 · 3.39 Impact Factor
  • Anxin Guo · Haitao Li · Xi Ba · Xinchun Guan · Hui Li ·
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    ABSTRACT: Coastal bridges in marine environments suffer from serious corrosion, resulting in the degradation of the seismic capacity of the structures during the long-term service period. This paper presents a cyclic experiment of coastal bridge piers considering the corrosion effects. Four test specimens, among which one is a sound structure and the others are structures with different levels of corrosion damage from accelerated corrosion, were used for the cyclic tests in this study. Using the measured force-displacement hysteretic responses, the effects of the corrosion damage on the seismic behavior of the specimens were investigated. The test results indicated that the seismic performance of the structure showed obvious degradation with the increase in the level of corrosion.
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    ABSTRACT: This work reports the fabrication and characterization of three-dimensional (3D) graphene aerogel (GA)–polydimethylsiloxane (PDMS) composites (GAPC) with outstanding mechanical, electrical and thermal properties. GAPC was fabricated by impregnating 3D GA frameworks with PDMS via ice-bath-assisted infiltration and vacuum curing processes. Because of the well-interconnected 3D GA frameworks, GAPC exhibits extremely large deformability (compressive strain = 80% and tensile strain = 90%), high electrical and thermal conductivities (1 S/cm and 0.68 W/(m K), respectively), a stable piezo-resistance effect, rapid electric Joule heating performance ((dT/dt)max > 3 °C/s under a heating power of 12 W/cm3), and high hydrophobicity (contact angle = 135°). Furthermore, GAPC exhibits a negative temperature coefficient of expansion with decreased electrical resistivity over a broad temperature range, indicating a typical semiconducting behavior and a dual two-dimensional/3D hopping conduction mechanism.
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    ABSTRACT: Fractional repetition (FR) codes are a family of repair-efficient storage codes that provide exact and uncoded node repair at the minimum bandwidth regenerating point. The advantageous repair properties are achieved by a tailor-made two-layer encoding scheme which concatenates an outer maximum-distance-separable (MDS) code and an inner repetition code. In this paper, we generalize the application of FR codes and propose heterogeneous fractional repetition (HFR) code, which is adaptable to the scenario where the repetition degrees of coded packets are different. We provide explicit code constructions by utilizing group divisible designs, which allow the design of HFR codes over a large range of parameters. The constructed codes achieve the system storage capacity under random access repair and have multiple repair alternatives for node failures. Further, we take advantage of the systematic feature of MDS codes and present a novel design framework of HFR codes, in which storage nodes can be wisely partitioned into clusters such that data reconstruction time can be reduced when contacting nodes in the same cluster.
    IET Communications 11/2015; 9(17):2095-2100. DOI:10.1049/iet-com.2014.1225 · 0.74 Impact Factor
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    ABSTRACT: A nanocomplex was developed for molecular sensing in living cells, based on the fluorophore-labeled aptamer and the polydopamine nanospheres (PDANS). Due to the interaction between ssDNA and PDANS, the aptamer was adsorbed onto the surface of PDANS forming the aptamer/PDANS nanocomplex, and the fluorescence was quenched by PDANS through FRET. In vitro assay, the introduction of adenosine triphosphate (ATP) led to the dissociation of the aptamer from the PDANS and the recovery of the fluorescence. The retained fluorescence of the nanocomplex was found to be linear with the concentration of ATP in the range of 0.01-2 mM, and the nanocomplex was highly selective towards ATP. For the strong protecting capability to nucleic acids from enzymatic cleavage and the excellent biocompatibility of PDANS, the nanocomplex was transported into cells and successfully realized "signal on" sensing of ATP in living cells, moreover the nanocomplex could be employed for ATP semi-quantification. This design provides a strategy to develop biosensors based on the polydopamine nanomaterials for intracellular molecules analysis. For the advantages of polydopamine, it would be an excellent candidate for many biological applications, such as gene and drug delivery, intracellular imaging and in vivo monitoring.
    Analytical Chemistry 11/2015; DOI:10.1021/acs.analchem.5b03075 · 5.64 Impact Factor
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    ABSTRACT: In this article, thin flexible sandwiched Graphite-PET Sheets (GPSs) with 10 μm thick graphite interlayer as self-heating element are developed and reveal a desirable electrical resistance and an excellent mechanical flexibility. Employing these promising properties, a GPSs based self-snow-thawing pavement system is proposed with GPSs adopted as a high efficient electro-heating element. Powered by the alternative energies (grid power or solar energy), the snow-thawing experiments are implemented at the outdoor site under the impacts of multi-parameters (ambient temperature, wind speed, snow density and thickness and input power). The temperature distributions of pavement, feasibility, time/energy efficiency and economic cost are systematically evaluated though snow-thawing experiments. With advantages of desirable feasibility, high efficiency, long-term stability, low economic cost and environmental protection, the GPSs-based self-snow-thawing pavement is verified promising potential in snow-thawing applications.
    Cold Regions Science and Technology 11/2015; 122:10-17. DOI:10.1016/j.coldregions.2015.10.016 · 1.37 Impact Factor
  • Shulian Wu · Zheng Huang · Yunxia Wang · Hui Li ·

    Journal of Innovative Optical Health Sciences 11/2015; DOI:10.1142/S1793545816500140 · 0.93 Impact Factor
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    ABSTRACT: X-ray powder diffraction data, unit-cell parameters, and space group for drospirenone, C 24 H 30 O 3 , are reported [ a = 12.897(1) Å, b = 12.618(1) Å, c = 12.252(1) Å, α = β = γ = 90°, unit-cell volume V = 1994.13 Å 3 , Z = 4, ρ cal = 1.229 g cm −3 , and space group P 2 1 2 1 2 1 ]. All measured lines were indexed and are consistent with the P 2 1 2 1 2 1 space group. No detectable impurities were observed.
    Powder Diffraction 11/2015; DOI:10.1017/S0885715615000822 · 0.64 Impact Factor
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    ABSTRACT: X-ray powder diffraction data, unit-cell parameters, and space group for tectoridin, C 22 H 22 O 11 , are reported [ a = 13.577 (2) Å, b = 10.466 (8) Å, c = 9.454 (7) Å, α = 85.709 (4)°, β = 94.855 (3)°, γ = 101.485 (3)°, unit-cell volume V = 1309.50 Å 3 , Z = 2, ρ = 1.179 × 10 3 kg m −3 , and space group P 1]. No detectable impurity was observed.
    Powder Diffraction 11/2015; DOI:10.1017/S0885715615000810 · 0.64 Impact Factor
  • Anxin Guo · Qinghe Fang · Hui Li ·
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    ABSTRACT: Hurricane waves are catastrophic disasters that cause damage to coastal bridges with insufficient clearance. This study presents an analytical method to estimate the wave forces acting on a submerged bridge superstructure during a hurricane based on the potential flow approach. The boundary value problem of the submerged bridge deck under wave action is analyzed first, and the mathematical formula for the analytical solution is derived using the eigenfunction matching method. To validate the effectiveness of the analytical model, results are compared to test data from two hydrodynamic experiments on the wave action of bridge decks. Finally, the AASHTO model is discussed, and a simple method for estimating the maximum horizontal and vertical wave forces is proposed. The analysis results indicate that the proposed analytical model can be used effectively for prediction of the maximum wave forces acting on a submerged bridge superstructure during hurricane waves.
  • Wen-Li Chen · Yong Cao · Hui Li · Hui Hu ·

    Journal of Fluids and Structures 11/2015; 59:22-36. DOI:10.1016/j.jfluidstructs.2015.09.002 · 2.02 Impact Factor
  • Zhongyu Lu · Guijun Xian · Hui Li ·

    Construction and Building Materials 11/2015; DOI:10.1016/j.conbuildmat.2015.10.207 · 2.30 Impact Factor
  • Songchol Mun · Yuequan Bao · Hui Li ·

    Geophysical Journal International 11/2015; 203(2):818-827. DOI:10.1093/gji/ggv348 · 2.56 Impact Factor

  • Experiments in Fluids 11/2015; 56(11). DOI:10.1007/s00348-015-2077-5 · 1.67 Impact Factor
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    Haiquan Jing · Yong Xia · Hui Li · Youlin Xu · Yongle Li ·

    Journal of Fluids and Structures 11/2015; 59:316-327. DOI:10.1016/j.jfluidstructs.2015.09.008 · 2.02 Impact Factor
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    Qing Wang · Ya Ping Li · Shan Shan Li · Bin Tang · Hui Li ·
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    ABSTRACT: X-ray powder diffraction data for 1-(4-aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone, C 15 H 19 N 3 O 2 , are reported [ a = 14.877(4) Å, b = 5.893(6) Å, c = 18.984(3) Å, α = 90°, β = 122.298(3)°, γ = 90°, unit-cell volume V = 1406.86 Å 3 , Z = 4, and space group P 2 1 / c ]. All measured lines were indexed and are consistent with the P 2 1 / c space group. No detectable impurities were observed.
    Powder Diffraction 10/2015; DOI:10.1017/S088571561500072X · 0.64 Impact Factor
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    ABSTRACT: Conduction of pressurized water through two-dimensional (2D) layers in monolithic folded-graphene aerogels (FGA) is investigated experimentally. The synthesized FGA has a regular layered structure with a uniform d-spacing around 20 nm. Compared with one-dimensional nanofluidics in carbon nanotube arrays that have a similar characteristic length scale, the conduction pressure of FGA is much lower by nearly 2/3. The reduction in pressure may be attributed to the more energetically favourable molecular configurations in the 2D nanoenvironment, associated with the relaxation of lateral constraints of water molecules. The water conduction pressure through FGA rises exponentially with the sample thickness, due to the interlayer resistance. This finding may find wide applications in nanotransportation, nanofiltration, and nanofluidic energy management.
    Journal of Physics D Applied Physics 10/2015; 48(42):425301. DOI:10.1088/0022-3727/48/42/425301 · 2.72 Impact Factor
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    ABSTRACT: Cyclodextrin-related host-guest encapsulation is fundamental to modulate the solubility of riluzole (RLZ), promoting its potential pharmaceutical applications. The supramolecular interaction of RLZ and hydroxypropyl-β-cyclodextrin (HP-β-CD) was examined through FT-IR spectroscopy, DSC-TGA, PXRD, (1)HNMR, 2D ROESY, ssNMR, and SEM. The HP-β-CD/RLZ inclusion complex was formed at a molar ratio of 1:1. The stability constant (K=2327M(-1)) and the corresponding thermodynamic parameters were ascertained through phase solubility studies. The water solubility and dissolution rate of RLZ notably increased in the presence of HP-β-CD, whereas the inclusion complex did not increase the RLZ toxicity toward the LO2 cell line. The influence of HP-β-CD on RLZ-human serum albumin (HSA) binding was investigated via fluorescence spectroscopy. Fluorescence quenching of HSA by RLZ in the presence and absence of HP-β-CD were both static quenching. Data analysis showed that the addition of HP-β-CD weakened the quenching and binding of RLZ with HSA but did not affect the binding site and binding force between RLZ and HSA. Furthermore, molecular models were generated to determine the binding site between HSA and RLZ, and these models were consistent with the experimental data.
    Journal of pharmaceutical and biomedical analysis 10/2015; 117:453-463. DOI:10.1016/j.jpba.2015.09.033 · 2.98 Impact Factor

Publication Stats

6k Citations
1,659.23 Total Impact Points


  • 2015
    • North China University of Water Conservancy and Electric Power
      Cheng, Henan Sheng, China
    • Baylor College of Medicine
      • Department of Molecular & Human Genetics
      Houston, Texas, United States
  • 2010-2015
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • Peking Union Medical College Hospital
      • Department of Obstetrics and Gynecology
      Peping, Beijing, China
    • Harbin Engineering University
      Charbin, Heilongjiang Sheng, China
    • China Pharmaceutical University
      • Division of Analytical Chemistry
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2008-2015
    • Chinese Academy of Sciences
      • • Laboratory of Theoretical Condensed Matter Physics and Computational Materials Physics
      • • Key Laboratory of Pathogenic Microbiology and Immunology
      • • Polymer Engineering Laboratory
      • • Graduate School
      • • Division of Cell and Stem Cell Biology
      Peping, Beijing, China
  • 2006-2015
    • Shanghai Jiao Tong University
      • Department of General Surgery
      Shanghai, Shanghai Shi, China
    • Nanjing University
      • Department of Chemical Engineering
      Nan-ching, Jiangsu Sheng, China
    • Iowa State University
      • Department of Chemistry
      Ames, IA, United States
  • 2004-2015
    • Harbin Institute of Technology
      • • School of Civil Engineering
      • • Department of Transportation Engineering
      Charbin, Heilongjiang Sheng, China
    • Fudan University
      • Department of Pathology
      Shanghai, Shanghai Shi, China
    • Sichuan University
      • • College of Chemical Engineering
      • • Institute of Atomic and Molecular Physics
      • • Department of Chemical Engineering
      Hua-yang, Sichuan, China
  • 2003-2015
    • Peking University
      • • Shenzhen Graduate School
      • • Department of Chemical Biology
      • • School of Pharmaceutical Sciences
      Peping, Beijing, China
  • 1996-2015
    • Fujian Normal University
      • College of Life Sciences
      Fujiang, Heilongjiang Sheng, China
  • 2014
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
    • Tianjin Medical University
      T’ien-ching-shih, Tianjin Shi, China
    • The Chinese University of Hong Kong
      • Department of Information Engineering
      Hong Kong, Hong Kong
    • Shaoxing University
      Shao-hsing, Zhejiang Sheng, China
  • 2011-2014
    • Southeast University (China)
      Nan-ching-hsü, Jiangxi Sheng, China
    • Shenzhen Second People's Hospital
      Shen-ch’üan-shih, Zhejiang Sheng, China
    • East China University of Science and Technology
      Shanghai, Shanghai Shi, China
    • Northeastern University (Shenyang, China)
      Feng-t’ien, Liaoning, China
    • Zhejiang University
      • Department of Environmental Science
      Hang-hsien, Zhejiang Sheng, China
  • 2008-2014
    • University of Nebraska at Lincoln
      • Department of Chemistry
      Lincoln, Nebraska, United States
  • 2004-2014
    • Guangdong Center for Disease Control and Prevention
      Shengcheng, Guangdong, China
  • 2013
    • Sun Yat-Sen University
      Shengcheng, Guangdong, China
    • Central South University
      Ch’ang-sha-shih, Hunan, China
  • 2009-2013
    • Renji Hospital
      Shanghai, Shanghai Shi, China
    • National University of Singapore
      • Department of Chemistry
      Tumasik, Singapore
    • Michigan State University
      Ист-Лансинг, Michigan, United States
    • China Agricultural University
      • College of Engineering
      Beijing, Beijing Shi, China
  • 2012
    • Peking Union Medical University
      Peping, Beijing, China
    • Mianyang Normal University
      Mien-yang-hsien, Sichuan, China
    • Southwest Jiaotong University
      • School of Information Science and Technology
      Hua-yang, Sichuan, China
    • Ruijin Hospital North
      Shanghai, Shanghai Shi, China
  • 2006-2012
    • Kunming Institute of Zoology CAS
      • State Key Laboratory of Genetic Resources and Evolution
      Yün-nan, Yunnan, China
  • 2009-2010
    • Handan College
      Han-tan-shih, Hebei, China
  • 2007
    • Jimei University
      Amoy, Fujian, China
    • China Earthquake Administration
      Peping, Beijing, China
  • 2005
    • Northeast Forestry University
      Charbin, Heilongjiang Sheng, China
  • 2004-2005
    • Second Military Medical University, Shanghai
      Shanghai, Shanghai Shi, China
  • 2002-2004
    • University of Iowa
      • Department of Chemistry
      Iowa City, Iowa, United States
    • School of Pharmaceutical Sciences of Shandong
      Chi-nan-shih, Shandong Sheng, China
  • 1999-2000
    • Fujian Teachers University
      Min-hou, Fujian, China
    • Beijing Medical University
      • School of Pharmaceutical Sciences
      Peping, Beijing, China
  • 1998-1999
    • Shanghai Institute of Health Sciences
      Shanghai, Shanghai Shi, China