Hui Li

North China University of Water Conservancy and Electric Power, Cheng, Henan Sheng, China

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Publications (807)1943.82 Total impact

  • Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 01/2016; 153:612-618. DOI:10.1016/j.saa.2015.09.017 · 2.35 Impact Factor
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    ABSTRACT: A carbon nano-fiber based conductive polymer (CNFP) film was fabricated by multi-scale carbon nano-fibers (10 ~ 200 nm) an in-situ filtrating casting process, due to the well-connected hierarchical microstructures and strong-wrapped assembling among carbon nano-fibers, the as-prepared CNFP presents excellent electrical conductivity, high thermo-electric performance and good mechanical properties. And the resistivity of the CNFP exhibited piecewise linear temperature-dependent characteristics within a certain temperature range (0 ~ 280 °C). Furthermore, based on excellent electric and thermo-electric properties, CNFP was employed as electric heating element to develop a novel self-deicing road system. This CNFP-based deicing system is consisted of CNFP as thermal source, an AlN-ceramic insulated encapsulation layer, a multiwall carbon nanotube (MWCNT)/cement-based thermal conduction layer and a thermally insulated substrate. Additionally, the MWCNT/cement-based composite, which was filled with 3% by weight MWCNT, was proposed as the thermal conduction layer because its thermal conduction properties are superior to those of cement with other fillers and to those of common cement-based composites. To ensure the efficient operation of the CNFP, an AlN-ceramic wafer (0.5 mm) was employed as the electro-insulated layer because of its favorable insulating and thermo-conductive properties. The constructed system was applied in deicing and field snow-thawing studies, in which the effects of ambient temperature, heat flux density and ice thickness on the deicing and snow-thawing performance of the self-deicing system were investigated. The efficiency, repeatability, cost and feasibility of the self-deicing road system in both deicing and snow-thawing applications were analyzed. Indices for evaluating the deicing or snow-thawing performance of the self-deicing road system were proposed and the optimal values for each parameter are presented. The results demonstrate the promise of CNFP as heating element of self-heating pavement on a wide application in deicing or snow-thawing for infrastructures, including pavement, highway, airport and bridge.
    Innovative Developments of Advanced Multifunctional Nanocomposites in Civil and Structural Engineering, Edited by K.J. Loh, S. Nagarajaiah, 01/2016: chapter Chapter 10; Woodhead Publishing: Cambridge, England.
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    ABSTRACT: Considering the harmful impact of food antioxidants on human bodies, thoroughly exposing their potential effects at the molecular level is important. In this study, the binding interactions of butylated hydroxyanisole (BHA), a phenolic antioxidant, and its different major metabolites tert-butylhydroquinone (TBHQ) and tert-butylbenzoquinone (TBQ) with lysozyme were examined via fluorescence, three-dimensional fluorescence, circular dichroism (CD), and ligand-protein docking studies. The three compounds caused strong quenching of lysozyme fluorescence by a static quenching mechanism but with different quenching efficiencies and different effects on the α-helix content of the lysozyme. The order of binding affinity of lysozyme for all test compounds is as follows: BHA>TBQ>TBHQ. Thermodynamic parameters indicated that hydrogen bonding and van der Waals forces perform dominant functions in the binding between these compounds and lysozyme. Furthermore, structure-affinity relationships between the model compounds and lysozyme were established on the basis of computational analyses. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Food Chemistry 12/2015; 188. DOI:10.1016/j.foodchem.2015.05.013 · 3.39 Impact Factor
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    ABSTRACT: This work reports the fabrication and characterization of three-dimensional (3D) graphene aerogel (GA)–polydimethylsiloxane (PDMS) composites (GAPC) with outstanding mechanical, electrical and thermal properties. GAPC was fabricated by impregnating 3D GA frameworks with PDMS via ice-bath-assisted infiltration and vacuum curing processes. Because of the well-interconnected 3D GA frameworks, GAPC exhibits extremely large deformability (compressive strain = 80% and tensile strain = 90%), high electrical and thermal conductivities (1 S/cm and 0.68 W/(m K), respectively), a stable piezo-resistance effect, rapid electric Joule heating performance ((dT/dt)max > 3 °C/s under a heating power of 12 W/cm3), and high hydrophobicity (contact angle = 135°). Furthermore, GAPC exhibits a negative temperature coefficient of expansion with decreased electrical resistivity over a broad temperature range, indicating a typical semiconducting behavior and a dual two-dimensional/3D hopping conduction mechanism.
  • Wen-Li Chen · Yong Cao · Hui Li · Hui Hu
    Journal of Fluids and Structures 11/2015; 59:22-36. DOI:10.1016/j.jfluidstructs.2015.09.002 · 2.02 Impact Factor
  • Journal of Physics D Applied Physics 10/2015; 48(42):425301. DOI:10.1088/0022-3727/48/42/425301 · 2.72 Impact Factor
  • Journal of inclusion phenomena and macrocyclic chemistry 10/2015; 83(1-2). DOI:10.1007/s10847-015-0556-1 · 1.43 Impact Factor
  • Jin Yan · Di Wu · Xiaoli Ma · Lili Wang · Kailin Xu · Hui Li
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    ABSTRACT: The binding mechanism of aripiprazole (APZ) with human serum albumin (HSA) in the absence and presence of three cyclodextrins (CyDs) (β-cyclodextrin, hydroxypropyl-β-cyclodextrin, and (2,6-di-O-methyl)-β-cyclodextrin) was studied by fluorescence, ultraviolet-visible absorption, nuclear magnetic resonance, and circular dichroism (CD) spectroscopy. The CD results revealed some degree of recovery of refolding caused by APZ after the addition of CyD. The Stern-Volmer quenching constant and binding constant of the APZ-HSA interaction were smaller in the presence of the three CyDs. The ultraviolet-visible absorption results indicated that APZ formed 1:1 complex with the three CyDs. The (1)H NMR spectra of CyD showed chemical shift and resolution loss of proton after the addition of HSA. Molecular modeling studies showed that both APZ and CyD bind to HSA. The process was initiated through inclusion of free APZ molecules by CyD and the increase in steric hindrance of CyD-HSA binding. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate Polymers 10/2015; 131:65-74. DOI:10.1016/j.carbpol.2015.05.037 · 4.07 Impact Factor
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    ABSTRACT: In this study, we further investigated a previously developed aptamer targeting ROS 17/2.8 (rat osteosarcoma) cells. We found that this C6-8 aptamer specifically binds to heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 and that it specifically labeled multiple tumor-cell lines as effectively as hnRNP A2/B1 monoclonal antibodies. When conjugated with fluorescent carbon nanodots (CDots) it could freely enter multiple living tumor cell lines (HepG2, MCF-7, H1299, and HeLa), whose growth it inhibited by targeting hnRNP A2/B1. Similar inhibitory effects were observed when the GFP-HepG2 hepatocarcinoma cells treated with C6-8-conjugated CDots were implanted in nude mice. Our work provides a new aptamer for targeting/labeling multiple tumor cell types, and its nanoparticle conjugates bring further advantages that increase its potential for use in cancer diagnosis and therapy. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Biomaterials 09/2015; 63. DOI:10.1016/j.biomaterials.2015.06.013 · 8.56 Impact Factor
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    ABSTRACT: In this article, a flax fiber yarn was grafted with nanometer sized TiO2, and the effects on the tensile and bonding properties of the single fibers and unidirectional fiber reinforced epoxy plates were studied. The flax fiber yarn was grafted with nanometer sized TiO2 through immersion in nano-TiO2/KH560 suspensions under sonification. The measured grafting content of the nano-TiO2 ranged from 0.89 wt.% to 7.14 wt.%, dependent on the suspension concentration. With the optimized nano-TiO2 grafting content (∼2.34 wt.%), the tensile strength of the flax fibers and the interfacial shear strength to an epoxy resin were enhanced by 23.1% and 40.5%, respectively. The formation of Si–O–Ti and C–O–Si bonds and the presence of the nano-TiO2 particles on the fiber surfaces contributed to the property enhancements. Unidirectional flax fiber reinforced epoxy composite (Vf = 35.4%) plates prepared manually showed significantly enhanced flexural properties with the grafting of nano-TiO2.
    Composites Part A Applied Science and Manufacturing 09/2015; 76. DOI:10.1016/j.compositesa.2015.05.027 · 3.07 Impact Factor
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    ABSTRACT: The interaction between niclosamide (NIC) and pepsin was investigated using multispectroscopic and molecular docking methods. Binding constant, number of binding sites, and thermodynamic parameters at different temperatures were measured. Results of fluorescence quenching and synchronous fluorescence spectroscopy in combination with three-dimensional fluorescence spectroscopy showed that changes occurred in the microenvironment of tryptophan residues and the molecular conformation of pepsin. Molecular interaction distance and energy-transfer efficiency between pepsin and NIC were determined based on Förster nonradiative energy-transfer mechanism. Furthermore, the binding of NIC inhibited pepsin activity in vitro. All these results indicated that NIC bound to pepsin mainly through hydrophobic interactions and hydrogen bonds at a single binding site. In conclusion, this study provided substantial molecular-level evidence that NIC could induce changes in pepsin structure and conformation.
    Journal of Fluorescence 09/2015; DOI:10.1007/s10895-015-1655-5 · 1.93 Impact Factor
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    ABSTRACT: Rapid, cost-effective, sensitive and specific analysis of biomolecules is important in the modern healthcare system. Here, a fluorescent biosensing platform based on the polydopamine nanospheres (PDANS) intergrating with Exonuclease III (Exo III) was developed. Due to the interaction between the ssDNA and the PDANS, the fluorescence of 6-carboxyfluorescein (FAM) labelled in the probe would been quenched by PDANS through FRET. While, in the present of the target DNA, the probe DNA would hybridize with the target DNA to form the double-strand DNA complex. Thus, Exo III could catalyze the stepwise removal of mononucleotides from 3'-terminus in the probe DNA, releasing the target DNA. As the FAM was released from the probe DNA, the fluorescence would no longer been quenched, led to the signal on. As one target DNA molecule could undergo a number of cycles to trigger the degradation of abundant probe DNA, Exo III-assisted target recycling would led to the amplification of the signal. The detection limit for DNA was 5pM, which was 20 times lower than that without Exo III. And the assay time was largely shortened due to the faster signal recovery kinetics. What is more, this target recycling strategy was also applied to conduct an aptamer-based biosensing platform. The fluorescence intensity was also enhanced for the assay of adenosine triphosphate (ATP). For the Exo III-assisted target recycling amplification, DNA and ATP were fast detected with high sensitivity and selectivity. This work provides opportunities to develop simple, rapid, economical, and sensitive biosensing platforms for biomedical diagnostics. Copyright © 2015. Published by Elsevier B.V.
    Biosensors & Bioelectronics 09/2015; 71. DOI:10.1016/j.bios.2015.04.029 · 6.41 Impact Factor
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    ABSTRACT: Fractional repetition (FR) codes are a family of repair-efficient storage codes that provide exact and uncoded node repair at the minimum bandwidth regenerating point. The advantageous repair properties are achieved by a tailor-made two-layer encoding scheme which concatenates an outer maximum-distance-separable (MDS) code and an inner repetition code. In this paper, we generalize the application of FR codes and propose heterogeneous fractional repetition (HFR) code, which is adaptable to the scenario where the repetition degrees of coded packets are different. We provide explicit code constructions by utilizing group divisible designs, which allow the design of HFR codes over a large range of parameters. The constructed codes achieve the system storage capacity under random access repair and have multiple repair alternatives for node failures. Further, we take advantage of the systematic feature of MDS codes and present a novel design framework of HFR codes, in which storage nodes can be wisely partitioned into clusters such that data reconstruction time can be reduced when contacting nodes in the same cluster.
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    ABSTRACT: The incidence of breast cancer has increased in Asian countries and rates of hormone receptor (HR) negative breast cancer exceed those of Western countries. Epidemiologic data suggest that the association between body size and BC risk may vary by HR status, and could differ geographically. While body size may influence BC risk by moderating the synthesis and metabolism of circulating sex-steroid hormones, insulin-like growth factor (IGF)-1 and related binding proteins, there is a dearth of literature among Asian women. We aimed to examine these specific associations in a sample of Chinese women. In Sichuan Province 143 women aged ≥40 years were recruited through outpatient services (2011-2012). Questionnaires, anthropometric measurements, and blood samples were utilized for data collection and linear regression was applied in data analyses. Among women <50 years we observed a non-monotonic positive association between body mass index (BMI) and 17β-estradiol, and a reversed J-shaped association between BMI and IGF-1 (p ≤0.05). We observed similar associations between waist-to-hip ratio and these markers. Our finding of augmented IGF-1 among women with low body mass may have implications for understanding breast tumor heterogeneity in diverse populations and should be evaluated in larger prospective studies with cancer outcomes.
    PLoS ONE 09/2015; 10(9):e0137686. DOI:10.1371/journal.pone.0137686 · 3.23 Impact Factor
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    ABSTRACT: Recently reported synthetic organic nanopore (SONP) can mimic a key feature of natural ion channels, i.e., selective ion transport. However, the physical mechanism underlying the K(+)/Na(+) selectivity for the SONPs is dramatically different from that of natural ion channels. To achieve a better understanding of the selective ion transport in hydrophobic subnanometer channels in general and SONPs in particular, we perform a series of ab initio molecular dynamics simulations to investigate the diffusivity of aqua Na(+) and K(+) ions in two prototype hydrophobic nanochannels: (i) an SONP with radius of 3.2 Å, and (ii) single-walled carbon nanotubes (CNTs) with radii of 3-5 Å (these radii are comparable to those of the biological potassium K(+) channels). We find that the hydration shell of aqua Na(+) ion is smaller than that of aqua K(+) ion but notably more structured and less yielding. The aqua ions do not lower the diffusivity of water molecules in CNTs, but in SONP the diffusivity of aqua ions (Na(+) in particular) is strongly suppressed due to the rugged inner surface. Moreover, the aqua Na(+) ion requires higher formation energy than aqua K(+) ion in the hydrophobic nanochannels. As such, we find that the ion (K(+) vs. Na(+)) selectivity of the (8, 8) CNT is ∼20× higher than that of SONP. Hence, the (8, 8) CNT is likely the most efficient artificial K(+) channel due in part to its special interior environment in which Na(+) can be fully solvated, whereas K(+) cannot. This work provides deeper insights into the physical chemistry behind selective ion transport in nanochannels.
    Proceedings of the National Academy of Sciences 09/2015; 112(35):10851-6. DOI:10.1073/pnas.1513718112 · 9.67 Impact Factor
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    ABSTRACT: Abstract – Wind power planning aims to locate and size wind farms optimally. Traditionally, wind power planners tend to choose the wind farms with the richest wind resources to maximize the energy benefit. However, the capacity benefit of wind power should also be considered in large-scale clustered wind farm planning because the correlation among the wind farms exerts an obvious influence on the capacity benefit brought about by the combined wind power. This paper proposes a planning model considering both the energy and the capacity benefit of the wind farms. The capacity benefit is evaluated by the wind power capacity credit. The Ordinal Optimization (OO) Theory, capable of handling problems with non-analytical forms, is applied to address the model. To verify the feasibility and advantages of the model, the proposed model is compared with a widely used genetic algorithm (GA) via a modified IEEE RTS-79 system and the real world case of Ningxia, China. The results show that the diversity of the wind farm enhances the capacity credit of wind power.
    Journal of Electrical Engineering and Technology 09/2015; 10(5):1930-1939. · 0.53 Impact Factor
  • Colloids and Surfaces A Physicochemical and Engineering Aspects 09/2015; DOI:10.1016/j.colsurfa.2015.09.062 · 2.75 Impact Factor
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    ABSTRACT: β-Cyclodextrin (β-CD) and 2,6-di-O-methyl-β-cyclodextrin (DM-β-CD) inclusion complexes with riluzole (RLZ) were prepared to improve water solubility and broaden potential pharmaceutical applications. CDs/RLZ inclusion complexes were confirmed via phase solubility studies, FT-IR spectroscopy, PXRD, DSC, (1)H NMR, and SEM. Phase solubility studies indicated that β-CD and DM-β-CD can form 1:1 inclusion complexes with RLZ, and the stability constants were 663.17 and 1609.07M(-1), respectively. Water solubility and dissolution rate of RLZ were significantly improved in complex forms, implying that the inclusion complexes may develop pharmaceutical applications. Preliminary in vitro cytotoxicity assay also showed that RLZ hepatotoxicity was not increased in the inclusion complexes. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate Polymers 09/2015; 129:9-16. DOI:10.1016/j.carbpol.2015.04.046 · 4.07 Impact Factor
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    ABSTRACT: We present a comprehensive computational study of NH2 (radical) solvation in a water nanodroplet. The ab initio Born-Oppenheimer molecular dynamics simulation shows that NH2 tends to accumulate at the air-water interface. The hydrogen bonding analysis shows that compared to the hydrogen bond of HNH··OH2, the hydrogen bond of HOH··NH2 is the dominant interaction between NH2 and water. Due to the loose hydrogen bonding network formed between NH2 and the droplet interface, the NH2 can easily move around on the droplet surface, which speeds up the dynamics of NH2 at the air-water interface. Moreover, the structural analysis indicates that the NH2 prefers an orientation such that both N atom and one of its H atoms interact with the water droplet while the other H atom is mostly ex-posed to the air. The exposed hydrogen becomes a more probable reactive site for reaction at the water interface. More importantly, the solvation of NH2 modifies the amplitude of vibration of the N-H bond, thereby affecting the Mulliken charges and electrophilicity of NH2. As such, reactive properties of the NH2 are altered by the droplet interface and this can either speed up reactions or allow other reactions processes to occur in the atmosphere. Hence, the solvation of NH2 on water droplets, in chemistry of the atmosphere, may not be negligible when considering the effects of clouds.
    Journal of the American Chemical Society 09/2015; DOI:10.1021/jacs.5b07354 · 12.11 Impact Factor

Publication Stats

8k Citations
1,943.82 Total Impact Points


  • 2015
    • North China University of Water Conservancy and Electric Power
      Cheng, Henan Sheng, China
    • State Grid Electric Power Research Institute
      Nan-ching-hsü, Jiangxi Sheng, China
    • Beijing FivePlus Molecular Medicine Institute
      Peping, Beijing, China
  • 2011–2015
    • Chongqing University
      • State Key Laboratory of Power Transmission Equipment and System Security and New Technology
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Northeastern University (Shenyang, China)
      Feng-t’ien, Liaoning, China
    • East China University of Science and Technology
      Shanghai, Shanghai Shi, China
    • Shanghai Putuo District People's Hospital
      Shanghai, Shanghai Shi, China
  • 2010–2015
    • Peking Union Medical College Hospital
      • Department of Obstetrics and Gynecology
      Peping, Beijing, China
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • China Pharmaceutical University
      • Division of Analytical Chemistry
      Nan-ching-hsü, Jiangxi Sheng, China
    • China Agriculture University-East
      Peping, Beijing, China
  • 2008–2015
    • Guangxi Medical University
      • Department of Cardiology
      Yung-ning, Guangxi Zhuangzu Zizhiqu, China
  • 2006–2015
    • Shanghai Jiao Tong University
      • Department of General Surgery
      Shanghai, Shanghai Shi, China
    • Nanjing University
      • Department of Chemical Engineering
      Nan-ching, Jiangsu Sheng, China
    • Chinese Academy of Sciences
      • • Laboratory of Theoretical Condensed Matter Physics and Computational Materials Physics
      • • Key Laboratory of Pathogenic Microbiology and Immunology
      • • Polymer Engineering Laboratory
      • • Graduate School
      • • Division of Cell and Stem Cell Biology
      • • Institute of High Energy Physics
      Peping, Beijing, China
  • 2004–2015
    • Harbin Institute of Technology
      • • School of Civil Engineering
      • • Department of Transportation Engineering
      Charbin, Heilongjiang Sheng, China
    • Sichuan University
      • • Institute of Atomic and Molecular Physics
      • • College of Chemical Engineering
      • • Department of Epidemiology
      • • Department of Chemical Engineering
      Hua-yang, Sichuan, China
  • 2003–2015
    • Peking University
      • • Shenzhen Graduate School
      • • Health Science Center
      • • School of Pharmaceutical Sciences
      Peping, Beijing, China
  • 2014
    • Xidian University
      Ch’ang-an, Shaanxi, China
    • The Chinese University of Hong Kong
      • Department of Information Engineering
      Hong Kong, Hong Kong
  • 2013–2014
    • Central South University
      • Department of Chemistry Engineering
      Ch’ang-sha-shih, Hunan, China
    • Fuzhou General Hospital
      Min-hou, Fujian, China
    • Sun Yat-Sen University
      Shengcheng, Guangdong, China
    • Beijing University of Technology
      Peping, Beijing, China
  • 2012–2014
    • Southeast University (China)
      Nan-ching-hsü, Jiangxi Sheng, China
    • Tongji University
      Shanghai, Shanghai Shi, China
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
    • Fujian Provincial Cancer Hospital
      Min-hou, Fujian, China
    • Chongqing Cancer Hospital and Institute
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Shanxi Normal University
      Saratsi, Shanxi Sheng, China
    • Mianyang Normal University
      Mien-yang-hsien, Sichuan, China
    • Southwest Jiaotong University
      • School of Information Science and Technology
      Hua-yang, Sichuan, China
    • Ruijin Hospital North
      Shanghai, Shanghai Shi, China
  • 2011–2014
    • Shenzhen Second People's Hospital
      Shen-ch’üan-shih, Zhejiang Sheng, China
  • 2008–2014
    • University of Nebraska at Lincoln
      • Department of Chemistry
      Lincoln, Nebraska, United States
  • 2004–2014
    • Guangdong Center for Disease Control and Prevention
      Shengcheng, Guangdong, China
  • 2012–2013
    • Fujian Normal University
      Fujiang, Heilongjiang Sheng, China
  • 2009–2013
    • China Agricultural University
      • • College of Biological Sciences
      • • College of Food Science and Nutritional Engineering
      • • College of Engineering
      Peping, Beijing, China
    • Renji Hospital
      Shanghai, Shanghai Shi, China
    • Michigan State University
      Ист-Лансинг, Michigan, United States
    • Shanghai Institutes for Biological Sciences
      Shanghai, Shanghai Shi, China
    • Government of the People's Republic of China
      Peping, Beijing, China
    • Huazhong University of Science and Technology
      • Department of Electronics and Information Engineering
      Wu-han-shih, Hubei, China
    • National University of Singapore
      • Department of Chemistry
      Tumasik, Singapore
  • 2004–2013
    • Fudan University
      • Department of Pathology
      Shanghai, Shanghai Shi, China
  • 1999–2013
    • Beijing Medical University
      • • Department of Surgery
      • • School of Pharmaceutical Sciences
      Peping, Beijing, China
  • 2006–2012
    • Kunming Institute of Zoology CAS
      • State Key Laboratory of Genetic Resources and Evolution
      Yün-nan, Yunnan, China
  • 2009–2010
    • Handan College
      Han-tan-shih, Hebei, China
  • 2008–2009
    • Aalborg University
      Ålborg, North Denmark, Denmark
  • 2007
    • China Earthquake Administration
      Peping, Beijing, China
  • 2005–2007
    • Iowa State University
      • Department of Chemistry
      Ames, IA, United States
    • Northeast Forestry University
      Charbin, Heilongjiang Sheng, China
  • 2004–2005
    • Second Military Medical University, Shanghai
      Shanghai, Shanghai Shi, China
  • 2002–2004
    • University of Iowa
      • Department of Chemistry
      Iowa City, Iowa, United States
    • School of Pharmaceutical Sciences of Shandong
      Chi-nan-shih, Shandong Sheng, China
  • 1998–1999
    • Shanghai Institute of Health Sciences
      Shanghai, Shanghai Shi, China