Hyun Joo Youn

Publications (2)1.28 Total impact

• Article: Effects of several salt marsh plants on mouse spleen and thymus cell proliferation using mtt assay

  Youngwan Seo, Hee-Jung Lee, You Ah Kim, Hyun Joo Youn, Burm-Jong Lee
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  ABSTRACT: In the present study, we have tested the effects of 21 salt marsh plants on cell proliferation of mouse immune cells (spleen and thymus) using MTT assay in culture. The methanolic extracts of six salt marsh plants (Rosa rugosa, Ixeris tamagawaensis, Artemisia capillaris, Tetragonia tetragonoides, Erigeron annus, and Glehnia littoralis) showed very powerful suppressive effects of mouse immune cell death and significant activities of cell proliferationin vitro. Especially, the methanolic extract ofRosa rugosa was found to have fifteen times compared to the control treatment, demonstrating that Rosa rugosa may have a potent stimulation effect on immune cell proliferation. These results suggest that several salt marsh plants includingRosa rugosa could be useful for further study as an immunomodulating agent.
  Ocean Science Journal 04/2012; 40(4):209-212.
• Article: In vitro screening of seaweed extract on the proliferation of mouse spleen and thymus cell

  Youngwan Seo, Sung-Ho Kang, Hee-Jung Lee, You Ah Kim, Hyun Joo Youn, Burm-Jong Lee, Hosung Chung
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  ABSTRACT: A total number of 31 types of seaweed were assessed with regard to their effects on the proliferation of mouse spleen and thymus cells in a culture, using an MTT reduction assay. Acetone:dichloromethane (1∶1) extracts of three seaweed plants:Derbesia marina, Sargassum sp., andHisikia fuziformis, exhibited significantly positive effects on the survival of mouse spleen and thymus cellsin vitro. The acetone: dichloromethane (1∶1) extracts ofSargassum sp., in particular, much more potent effects on thymus cell activation than did any of the other types of seaweed. However, the methanol extracts ofSargassum ringgoldianium andChondrus crispus exerted a stimulatory influence only on the proliferation of mouse spleen cells, whereas the methanol extracts ofGrateloupia lanceolata exhibited significant cell proliferation properties in both spleen and thymus cells.
  Biotechnology and Bioprocess Engineering 04/2012; 11(2):160-163. · 1.28 Impact Factor