[show abstract][hide abstract] ABSTRACT: 2 Large cell calcifying Sertoli cell tumor of the testis (LCCSCT) is a rare tumor that is usually benign and multifocal. It may be associated with hereditary endocrine anomalies such as Carney's and Peutz-Jeghers syndromes. It is a rare histological variant of sex cord stromal tumors. It is exceptional in elderly men and the outcome is rarely fatal. We report a case of LCCSCT in a 44 year-old man with fatal outcome. The tumor involved the right testis and several areas of the tunica albuginea were grossly invaded. It composed of cords and trabeculae of large polygonal cells embedded in a myxoid and fibrous stroma with areas of calcification along with nuclear atypia, necrosis, and abundant mitoses. The Peutz-Jeghers syndrome (PJS) is known to be commonly associated with ovarian tumors. However, its association with testicular tumors is uncommon. To the best of our knowledge, this is the eight such case being reported in the literature. Our case, to our knowledge, is the only other reported case of malignant large cell calcifying Sertoli cell tumor with clinical and histopathological features related to aggressiveness, such as large tumor size, cellular pleomorphism, high mitotic rate, necrosis and aneuploid deoxyribonucleic acid. Such characteristics are not found in benign large cell calcifying Sertoli cell tumors.
[show abstract][hide abstract] ABSTRACT: Primary pleural lymphoma is a rare entity that has been described in association with human immunodeficiency virus (HIV) infection
or pyothorax. This paper reports on a 27 year old man with no history of HIV infection or pyothorax who presented with progressive
dyspnea and heaviness of chest. Chest radiography revealed complete opacification of the left hemithorax, and contrast enhanced
computed tomography showed large left pleural effusion and homogeneous, extensive thickening of the parietal pleura. CT guided
biopsy of thickened pleura is suggestive of non-Hodgkin’s lymphoma-T cell lymphoblastic variety. Physicians should be aware
of this rare location of primary pleural lymphoma manifested by thickening of the pleura.
Key Wordsnon-Hodgkin’s lymphoma–T cell–lymphoblastic type–lymphoma–extranodal NK-T-cell
Clinical Oncology and Cancer Research 04/2012; 8(1):47-50.
[show abstract][hide abstract] ABSTRACT: A 20-year-old boy presenting daily febrile episodes was suspected to have developed acute hepatic failure. Serologic tests
ruled out infectious and autoimmune causes apart from drug toxicity. During clinical examinations, he was found to have generalized
enlarged lymph nodes that were then taken biopsy. It was diagnosed as classical Hodgkin’s lymphoma based on histological examination
of the lymph node. A bone marrow biopsy showed marrow infiltration by Hodgkin’s lymphoma with hemophagocytosis and secondary
myelofibrosis. A percutaneous liver biopsy demonstrated hepatic involvement of the same disease. After an extensive work-up,
the cause of liver failure was figure out to be only attributed to the involvement of the lymphoma. Hodgkin’s lymphoma as
a cause of hepatic failure is rare and young patients diagnosed as Hodgkin’s lymphoma causing hepatic failure has been reported
very rarely so far.
Key WordsHodgkin’s disease–bone marrow–liver failure–acute
Clinical Oncology and Cancer Research 04/2012; 7(6):373-376.