Yi Wang

Chinese Academy of Sciences, Peping, Beijing, China

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Publications (266)924.87 Total impact

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    ABSTRACT: Using environmental wastes to produce energy materials is extremely attractive for economic social development. Herein, sludge flocs (SF), a kind of environmental wastes which are difficult to be disposed, were used as carbon and nitrogen source for the preparation of N-doped mesocellular graphene foam (SF-NMGF) via a simple one-step pyrolysis. Originated from the special composition and structure of SF, the obtained SF-NMGF had large Brunauer-Emmett-Teller surface areas, graphitic frameworks surrounded by ultrathin nanosheets, foam-like mesopores with size centered at about 15 nm, and homogeneous nitrogen incorporation with high percentage (40.5 at%) of graphitic nitrogen. Owing to these unique properties, SF-NMGF showed excellent electrocatalytic activity with 4e as a metal-free catalyst for the oxygen reduction reaction (ORR). Specifically, the prepared SF-NMGF catalyst exhibited high diffusion-limited current, superior durability and better immunity towards methanol crossover for ORR in alkaline solution than a commercial 20 wt% Pt/C catalyst. More importantly, the synthesis of SF-NMGF can be scaled up with low cost, which will be beneficial for both the sludge handling and development of ORR materials.
    06/2015; 3(29). DOI:10.1039/C5TA03060A
  • Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 06/2015; 17(6):577-9.
  • Yi Wang · Gao Lin · Zhiqiang Hu
    Journal of Engineering Mechanics 05/2015; 141(5):04014150. DOI:10.1061/(ASCE)EM.1943-7889.0000593 · 1.17 Impact Factor
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    ABSTRACT: Purpose The purpose of this study is to determine whether there is a relationship between continuous electroencephalography (EEG) monitoring patterns and prognosis for children with severe brain damage. Patients and Methods The different patterns of EEG were analyzed for 103 children (Glasgow Coma Scale [GCS] score < 8) who were monitored with continuous video-EEG (CVEEG) within 72 hours after the onset of coma. The clinical outcomes were scored and evaluated at hospital discharge by the modified Pediatric Cerebral and Overall Performance Category Scale (PCOPCS). EEG parameters of the different prognosis groups were compared and risk factors for prognosis were identified. Results Of the 103 children, 36 were in the good prognosis group (PCOPCS scores 1 and 2) and 67 were in the poor prognosis group (PCOPCS scores 3-6). The poor prognosis group had the lower proportion of events in reactive EEG patterns and sleep architecture, and a higher proportion of low-voltage events. Multivariate analyses showed that the lower GCS score and no sleep architecture were significantly associated with poor prognosis. Conclusions Comatose children with higher GCS score and sleep architecture have better clinical outcomes in terms of morbidity and mortality. Georg Thieme Verlag KG Stuttgart · New York.
    Neuropediatrics 04/2015; 46(03). DOI:10.1055/s-0035-1548673 · 1.10 Impact Factor
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    ABSTRACT: The use of somatostatin analogues (SAs) following pancreaticoduodenectomy (PD) is controversial. Literature databases were searched systematically for relevant articles. A meta-analysis of all randomized controlled trials (RCTs) evaluating prophylactic SAs in PD was performed. Fifteen RCTs involving 1,352 patients were included. There was a towards reduced incidences of pancreatic fistulas (p = 0.26), clinically significant pancreatic fistulas (p = 0.08), and bleeding (p = 0.05) in prophylactic SAs group. In subgroup analyses, prophylactic somatostatin significantly reduced the incidence of pancreatic fistulas (p = 0.02), with a nonsignificant trend toward reduced incidence of clinically significantly pancreatic fistulas (p = 0.06). Pasireotide significantly reduced the incidence of clinically significantly pancreatic fistulas (p = 0.03). Octreotide had no influence on the incidence of pancreatic fistulas. The current best evidence suggests prophylactic treatment with somatostatin or pasireotide has a potential role in reducing the incidence of pancreatic fistulas, while octreotide had no influence on the incidence of pancreatic fistulas. High-quality RCTs assessing the role of somatostatin and pasireotide are required for further verification. © 2015 S. Karger AG, Basel.
    Digestive surgery 04/2015; 32(3):196-207. DOI:10.1159/000381032 · 1.74 Impact Factor
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    ABSTRACT: A facile co-calcination strategy with simultaneous N-doping, carbon graphitization, and palladium ion (Pd2+) reduction under high temperature was used to derive Pd nanoparticles budded on N-doped ordered mesoporous graphitic carbon nanospheres (Pd/N-MCN). Pd/N-MCN was exploited as a cathode catalyst for the oxygen reduction reaction (ORR). It demonstrated strong stability with a relative current of 95% still persisting after 40 000 s. Most importantly, hybrids exhibited superior methanol tolerance, remaining stable after the addition of 2 M methanol in electrolyte. The outstanding performance of Pd/N-MCN in ORR could be attributed to its ordered mesopores, large surface area, homogeneous budding of abundant Pd active sites, graphitization generated by Pd catalysis, and the synergistic effects of Pd nanoparticles strongly coupled to N-MCN.
    Electrochimica Acta 04/2015; 160:306-312. DOI:10.1016/j.electacta.2015.01.157 · 4.50 Impact Factor
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    ABSTRACT: Hepatocyte nuclear factor 4-α (HNF4α), a nuclear receptor, is expressed at lower levels in colon carcinoma tissues than in adjacent normal tissues. However, the relation between HNF4α and colon cancer progression and the underlying molecular mechanisms remain unclear. Here, we investigated the role of HNF4α in the progression of colon carcinoma. We showed that HNF4α mRNA and protein were downregulated in colon carcinoma specimens. HNF4α expression was related to pT classification (P < 0.001), lymph node metastasis (P = 0.002), distant metastasis (P < 0.001) and clinical stage (P < 0.001) in colon carcinoma patients. Patients with low or negative HNF4α expression had worse 3-year progression-free survival (PFS, P = 0.006) and overall survival (OS, P = 0.005) than patients with high HNF4α expression. Low HNF4α expression was an independent prognostic factor for 3-year PFS (hazard ratio 2.94; 95% confidence interval 1.047-8.250; P = 0.041). Ectopic expression of HNF4α inhibited colon carcinoma cell (HT29, LoVo, and SW480) proliferation, migration, and invasion, induced G2/M phase arrest and promoted apoptosis. Ectopic expression of HNF4α upregulated E-cadherin and downregulated vimentin in vitro, and suppressed SW480 xenograft tumor growth and liver metastasis in vivo. Furthermore, HNF4α overexpression downregulated the expression of snail, slug and twist. HNF4α inhibited EMT through its effect on the Wnt/β-catenin signaling pathway, and HNF4α downregulation may be mediated by promoter methylation in cancer tissues. Our results suggest that downregulation of HNF4α plays a critical role in the aggravation of colon carcinoma possibly by promoting EMT via the Wnt/β-catenin signaling pathway and by affecting apoptosis and cell cycle progression. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    Molecular Carcinogenesis 03/2015; DOI:10.1002/mc.22294 · 4.77 Impact Factor
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    ABSTRACT: Cancer imaging requires biocompatible and bright contrast-agents with selective and high accumulation in the tumor region but low uptake in normal tissues. Herein, 1-methyl-2-pyrrolidinone (NMP)-derived polymer-coated nitrogen-doped carbon nanodots (pN-CNDs) with a particle size in the range of 5-15 nm are prepared by a facile direct solvothermal reaction. The as-prepared pN-CNDs exhibit stable and adjustable fluorescence and excellent water solubility. Results of a cell viability test (CCK-8) and histology analysis both demonstrate that the pN-CNDs have no obvious cytotoxicity. Most importantly, the pN-CNDs can expediently enter glioma cells in vitro and also mediate glioma fluorescence imaging in vivo with good contrast via elevated passive targeting. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Small 03/2015; 11(29). DOI:10.1002/smll.201403718 · 8.37 Impact Factor
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    ABSTRACT: To evaluate the impact of RA on work capacity and identify factors related to work capacity impairment in patients with RA. A cross-sectional multicentre study was performed in 21 tertiary care hospitals across China. A consecutive sample of 846 patients with RA was recruited, of which 589 patients of working age at disease onset constituted the study population. Information on the socio-demographic, clinical, working and financial conditions of the patients was collected. Logistic regression analyses were used to identify factors associated with work capacity impairment. The rate of work capacity impairment was 48.0% in RA patients with a mean disease duration of 60 months (interquartile range 14-134 months), including 11.7% leaving the labour force early, 33.6% working reduced hours and 2.7% changing job. Multivariable logistic regression analysis showed that reduced working hours was significantly related to current smoking [odds ratio (OR) 2.07 (95% CI 1.08, 3.97)], no insurance [OR 1.94 (95% CI 1.20, 3.12)], in manual labour [OR 2.66 (95% CI 1.68, 4.20)] and higher HAQ score [OR 2.22 (95% CI 1.36, 3.60)]. There was an association of current smoking [OR 3.75 (95% CI 1.54, 9.15)], in manual labour [OR 2.33 (95% CI 1.17, 4.64)], longer disease duration [OR 1.01 (95% CI 1.00, 1.01)] and lower BMI [OR 0.90 (95% CI 0.82, 0.99)] with leaving the labour force early. There is a substantial impact of RA on the work capacity of patients in China. Social-demographic, disease- and work-related factors are all associated with work capacity impairment. © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
    Rheumatology (Oxford, England) 03/2015; 54(8). DOI:10.1093/rheumatology/kev014 · 4.44 Impact Factor
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    ABSTRACT: The electrochemical oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) are of great interest since they are involved in energy conversion between fuel and electricity. Here, we developed a bifunctional MnO2/graphene/carbon nanotube that is free of noble metals and that could be a promising candidate electrocatalyst for these oxygen reduction and evolution reactions. It was shown to be able to act as an efficient cathode catalyst for the ORR, having a positive half-wave potential that differs by only 55 mV from that of commercial Pt/C, and a high cathodic current density that is comparable to that of the Pt/C catalyst. Moreover, the hybrid exhibited superior durability with nearly no decay in ORR activity even after 10000 s of continuous operation in 0.1 M KOH, while Pt/C shows a 20% decrease in the activity. Most importantly, the hybrid was also shown to be highly active for the OER. These observations show this hybrid to be a high-performance non-precious metal-based bi-catalyst for both the ORR and OER.
    RSC Advances 03/2015; 5(34). DOI:10.1039/C4RA14452J · 3.84 Impact Factor
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    ABSTRACT: Previous studies have reported significant associations of 5-HTTLPR with brain structures mainly in Europeans, but the situations in other ethnic groups remain largely unknown. Here we examined the association of 5-HTTLPR with regional gray matter volume in Han Chinese, and observed significant association in the postcentral gyrus and precuneus cortex. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    Psychiatry Research 01/2015; 226(1). DOI:10.1016/j.psychres.2015.01.022 · 2.68 Impact Factor
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    ABSTRACT: Background Currently, there is no cure for Duchenne and Becker muscular dystrophies (DMD/BMD). However, clinical trials with new therapeutic strategies are being conducted or considered. A comprehensive database is critical for patient recruitment and efficacy evaluation. China has the largest population, yet, no comprehensive database for DMD/BMD is available. Our study registered the data of the DMD/BMD patients in East China.MethodsA modified registry form of Remudy (http://www.remudy.jp/) was applied to Chinese DMD/BMD patients through the outpatient clinic at Children¿s Hospital of Fudan University, Shanghai during the period of August 2011 to December 2013. The data included geographic distribution of patients, age at diagnosis, clinical manifestation, genetic analysis and treatment status.Results194 DMD and 35 BMD patients were registered. Most patients lived in East China, namely Jiangsu province, Anhui province, Zhejiang province, Shanghai, Jiangxi province, Fujian province and Shandong province. All individuals aged less than 18 years (age limit to a children¿s hospital). Diagnosis was made for a majority of patients during the age of 3¿4 (16.6%) and 7¿8 (14.8%) years old. Exon deletion was the most frequent genetic mutations (65.5% and 74.3%) followed by point mutations (14.4% and 11.4%), duplications (9.8% and 8.6%) and small insertion/deletion (9.3% and 2.9%) for DMD and BMD, respectively. 82.5% of DMD registrants were ambulatory, and all the BMD registrants were able to walk. 26.3% of DMD registrants have been treated with steroids. Cardiac functions were examined for 46.4% DMD boys and 45.7% BMD boys and respiratory functions were examined for 18.6% DMD boys and 14.3% BMD boys. Four boys with abnormal cardiac function were prescribed for treatment with cardiac medicine. 33.2% of DMD patients are eligible for exon skipping therapy, and among them 9.2% and 4.3% patients are eligible for skipping exon 51 and 53, respectively.Conclusions The database is the first linking accurate genetic diagnosis with clinical manifestation and treatment status of dystrophinopathy patients in East China. It provides comprehensive information essential for further patient management, especially for promotion of international cooperation in developing experimental therapies such as exon skipping and read-through of nonsense mutations targeting a subgroup of DMD patient population.
    Orphanet Journal of Rare Diseases 01/2015; 10(1):5. DOI:10.1186/s13023-014-0220-7 · 3.96 Impact Factor
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    ABSTRACT: To evaluate effect of thrombolytic therapy with rt-PA (recombinant tissue plasminogen activator) and transcranial color Doppler ultrasound (TCCS) combined with microbubbles on histology of brain tissue.
    Clinical Neurology and Neurosurgery 01/2015; 131C. DOI:10.1016/j.clineuro.2015.01.011 · 1.25 Impact Factor
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    ABSTRACT: Pancreatic fistula is a leading cause of morbidity and mortality after pancreaticoduodenectomy. We introduce here a simple, secure and universal technique for pancreaticojejunostomy with a two-layer continuous running suture. We also report on the preliminary results for grades of pancreatic fistulas among patients who underwent this new technique. 51 consecutive cases were successfully performed using this new technique during pancreaticoduodenectomy. The overall morbidity was 29.4%. Only 3 (5.9%) grade B pancreatic fistulas were observed postoperatively, and were successfully treated with conservative management. The time taken to create the pancreatic anastomosis was less than 15 minutes in all cases. In conclusion, this novel pancreatic anastomosis technique is easy and quick to perform, universally applicable, and appears to be a secure technique that reduces pancreatic fistula rates after pancreaticoduodenectomy.
    Hepato-gastroenterology 01/2015; 62(137):184-6. · 0.91 Impact Factor
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    ABSTRACT: EPAS1 involves in the hypoxic response and is suggested to be responsible for the genetic adaptation of high-altitude hypoxia in Tibetans. However, the detailed molecular mechanism remains unknown. In this study, a single nucleotide polymorphism rs56721780:G>C and an insertion/deletion (indel) polymorphism -742 indel in the promoter region showed divergence between Tibetans and non-Tibetan lowlanders. rs56721780:G>C regulated the transcription of EPAS1 by IKAROS family zinc finger 1 (IKZF1), which was identified as a new transcriptional repressor for EPAS1 gene. It demonstrated that the C allele of rs56721780:G>C decreased the binding of IKZF1, leading to the attenuated transcriptional repression of EPAS1 gene. The insertion at -742 indel provided a new binding site for Sp1 and was related to the activation of EPAS1 promoter. Further functional analysis revealed that lysyl oxidase (LOX) gene, which was reported to be responsible for extracellular matrix protein cross-linking of amnion previously, was a direct target of EPAS1. The CC genotype at rs56721780:G>C and the insertion genotype at -742 indel were found associated with higher EPAS1 and LOX expression levels in amnion, as well as higher birth weight of Tibetan newborns, suggesting that EPAS1 gene might play important roles in the development of amnion, fetus growth and high-altitude adaptation of Tibetans.
    Scientific Reports 12/2014; 4:7465. DOI:10.1038/srep07465 · 5.58 Impact Factor
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    ABSTRACT: Perioperative allogeneic blood transfusion (ABT) may be a deleterious predictor on the prognosis of gastric cancer (GC) for subjects who had undergone curative surgeries. In this article we proposed to figure out the effect of ABT with a systematic review and meta-analysis. Relevant articles were identified by searching Pubmed and Embase to March 2014. A random-effects model or fixed-effects model was used to calculate pooled odds ratios (ORs). Sensitivity analysis, meta-regression, stratified analysis, dose-response meta-analysis were conducted, and publication bias tested. Eighteen studies (9120 GC patients) were included, of which 36.3% received transfusions. ABT was associated with increased all-cause mortality (OR, 2.17; 95% confidence interval [CI], 1.72-2.74; p<0.001; I(2)=75%). Sensitivity analysis showed significant changes in ORs while meta-regression had little influence on ORs. Galbraith plot revealed the OR reduced to 2.10 (95% CI, 1.86-2.37; p<0.001) with tau(2) reduced to 0.00 and I(2) reduced to 0%. Results of stratified analysis were robust and consistent. Dose-response meta-analysis revealed that all-cause mortality was significantly lower in patients transfused with ≤800 mL of blood than those transfused with >800 mL (OR, 0.58; 95% CI, 0.37-0.92; p=0.02; I(2)=54%). ABT was also associated with increased cancer-related mortality (OR, 2.57, p=0.011) and recurrence (OR, 1.52, p=0.017). In GC patients undergoing curative surgeries, ABTs are associated with a worse prognosis, including all-cause mortality, cancer-related mortality and recurrence. Patient blood management should be investigated further to minimize use of ABT. Copyright © 2014. Published by Elsevier Ltd.
    International Journal of Surgery (London, England) 12/2014; 13. DOI:10.1016/j.ijsu.2014.11.044 · 1.65 Impact Factor
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    ABSTRACT: The aim of this study is to investigate the remission rate of rheumatoid arthritis (RA) in China and identify its potential determinants. A multi-center cross-sectional study was conducted from July 2009 to January 2012. Data were collected by face-to-face interviews of the rheumatology outpatients in 28 tertiary hospitals in China. The remission rates were calculated in 486 RA patients according to different definitions of remission: the Disease Activity Score in 28 joints (DAS28), the Simplified Disease Activity Index (SDAI), the Clinical Disease Activity Index (CDAI), and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean definition. Potential determinants of RA remission were assessed by univariate and multivariate analyses. The remission rates of RA from this multi-center cohort were 8.6 % (DAS28), 8.4 % (SDAI), 8.2 % (CDAI), and 6.8 % (Boolean), respectively. Favorable factors associated with remission were: low Health Assessment Questionnaire (HAQ) score, absence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP), and treatment of methotrexate (MTX) and hydroxychloroquine (HCQ). Younger age was also predictive for the DAS28 and the Boolean remission. Multivariate analyses revealed a low HAQ score, the absence of anti-CCP, and the treatment with HCQ as independent determinants of remission. The clinical remission rate of RA patients was low in China. A low HAQ score, the absence of anti-CCP, and HCQ were significant independent determinants for RA remission.
    Clinical Rheumatology 11/2014; 34(2). DOI:10.1007/s10067-014-2828-3 · 1.77 Impact Factor
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    ABSTRACT: A method is presented for beam quality improvement, in master oscillator power amplifier laser systems. Intensive study was first carried out with the beam wavefront evolution in a laser resonator. When the laser beam propagates inside the resonator, the spherical aberration coefficient of the beam wavefront can change sign, i.e., the negative spherical aberration coefficient can turn to positive, and vice versa. This process also occurs when the beam propagates outside the resonator in a free space. The laser beam, from an oscillator with negative spherical aberration, was found to be well-compensated by the positive spherical aberration of a strongly pumped laser rod in a laser amplifier. The laser beam quality M2 factor has been significantly improved, from 2.2 to 1.4, while the output power has been scaled from 31 W up to 60 W.
    Applied Optics 11/2014; 53(33). DOI:10.1364/AO.53.007963 · 1.78 Impact Factor
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    ABSTRACT: Background and Objective Valproic acid (VPA) follows a non-linear pharmacokinetic profile in terms of protein-binding saturation. The total daily dose regarding VPA clearance is a simple power function, which may partially explain the non-linearity of the pharmacokinetic profile; however, it may be confounded by the therapeutic drug monitoring effect. The aim of this study was to develop a population pharmacokinetic model for VPA based on protein-binding saturation in pediatric patients with epilepsy. Methods A total of 1,107 VPA serum trough concentrations at steady state were collected from 902 epileptic pediatric patients aged from 3 weeks to 14 years at three hospitals. The population pharmacokinetic model was developed using NONMEM® software. The ability of three candidate models (the simple power exponent model, the dose-dependent maximum effect [DDE] model, and the protein-binding model) to describe the non-linear pharmacokinetic profile of VPA was investigated, and potential covariates were screened using a stepwise approach. Bootstrap, normalized prediction distribution errors and external evaluations from two independent studies were performed to determine the stability and predictive performance of the candidate models. Results The age-dependent exponent model described the effects of body weight and age on the clearance well. Co-medication with carbamazepine was identified as a significant covariate. The DDE model best fitted the aim of this study, although there were no obvious differences in the predictive performances. The condition number was less than 500, and the precision of the parameter estimates was less than 30 %, indicating stability and validity of the final model. Conclusion The DDE model successfully described the non-linear pharmacokinetics of VPA. Furthermore, the proposed population pharmacokinetic model of VPA can be used to design rational dosage regimens to achieve desirable serum concentrations.
    Clinical Pharmacokinetics 11/2014; 54(3). DOI:10.1007/s40262-014-0212-8 · 5.49 Impact Factor

Publication Stats

8k Citations
924.87 Total Impact Points


  • 2009–2015
    • Chinese Academy of Sciences
      • Institute of Applied Ecology
      Peping, Beijing, China
    • Nanjing University
      Nan-ching, Jiangsu Sheng, China
  • 2006–2015
    • Fudan University
      • • Department of Neurology
      • • Department of Chemistry
      • • School of Pharmacy
      • • Institutes of Biomedical Sciences
      • • School of Life Sciences
      • • Department of Electronic Engineering
      Shanghai, Shanghai Shi, China
    • Peking Union Medical College Hospital
      Peping, Beijing, China
  • 2014
    • Zhejiang University
      • State Key Lab of Modern Optical Instrumentation
      Hang-hsien, Zhejiang Sheng, China
    • Brigham and Women's Hospital
      • Department of Medicine
      Boston, Massachusetts, United States
  • 2012–2014
    • Nanjing General Hospital
      Nan-ching, Jiangsu Sheng, China
    • Peking University People's Hospital
      Peping, Beijing, China
  • 2005–2014
    • Tianjin University
      • School of Precision Instrument and Opto-Electronics Engineering
      T’ien-ching-shih, Tianjin Shi, China
  • 2003–2014
    • Second Military Medical University, Shanghai
      • Department of Anesthesiology
      Shanghai, Shanghai Shi, China
    • Chinese Academy of Medical Sciences
      Peping, Beijing, China
  • 2012–2013
    • Kunming Institute of Zoology CAS
      • State Key Laboratory of Genetic Resources and Evolution
      Yün-nan, Yunnan, China
  • 2007–2013
    • Shanghai Jiao Tong University
      • • School of Medicine
      • • Institute of Medical Genetics
      Shanghai, Shanghai Shi, China
    • Shanghai Putuo District People's Hospital
      Shanghai, Shanghai Shi, China
    • Sun Yat-Sen University Cancer Center
      Shengcheng, Guangdong, China
    • Nereus Life Science
      Medway, Massachusetts, United States
  • 2005–2013
    • Chinese National Human Genome Center at Shanghai
      Shanghai, Shanghai Shi, China
  • 2011–2012
    • Baylor College of Medicine
      • Human Genome Sequencing Center
      Houston, Texas, United States
    • Shanghai's Children's Medical Center
      Shanghai, Shanghai Shi, China
  • 2010–2012
    • Dalian University of Technology
      • School of Civil & Hydraulic Engineering
      Lü-ta-shih, Liaoning, China
    • Government of the People's Republic of China
      Peping, Beijing, China
    • Nanjing Medical University
      Nan-ching, Jiangsu Sheng, China
  • 2004–2011
    • Sun Yat-Sen University
      • • State Key Laboratory of Oncology
      • • Department of Hepatobiliary Surgery
      Shengcheng, Guangdong, China
    • The University of Hong Kong
      • Department of Clinical Oncology
      Hong Kong, Hong Kong
  • 2008
    • Peking University
      Peping, Beijing, China