Yi Wang

Chinese Academy of Sciences, Peping, Beijing, China

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Publications (280)976.4 Total impact

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    ABSTRACT: Preclinical studies show that GABA exerts anti-diabetic effects in rodent models of type 1 diabetes. Because little is known about its absorption and effects in humans, we investigated the pharmacokinetics and pharmacodynamics of GABA in healthy volunteers. Twelve subjects were subjected to an open-labeled, three-period trial involving sequential oral administration of placebo, 2 g GABA once, and 2 g GABA three times/day for 7 days, with a 7-day washout between each period. GABA was rapidly absorbed (Tmax: 0.5 ~ 1 h) with the half-life (t1/2) of 5 h. No accumulation was observed after repeated oral GABA administration for 7 days. Remarkably, GABA significantly increased circulating insulin levels in the subjects under either fasting (1.6-fold, single dose; 2.0-fold, repeated dose; p < 0.01) or fed conditions (1.4-fold, single dose; 1.6-fold, repeated dose; p < 0.01). GABA also increased glucagon levels only under fasting conditions (1.3-fold, single dose, p < 0.05; 1.5-fold, repeated dose, p < 0.01). However, there were no significant differences in the insulin-to-glucagon ratio and no significant change in glucose levels in these healthy subjects during the study period. Importantly, GABA significantly decreased glycated albumin levels in the repeated dosing period. Subjects with repeated dosing showed an elevated incidence of minor adverse events in comparison to placebo or the single dosing period, most notably transient discomforts such as dizziness and sore throat. However, there were no serious adverse events observed throughout the study. Our data show that GABA is rapidly absorbed and tolerated in human beings; its endocrine effects, exemplified by increasing islet hormonal secretion, suggest potential therapeutic benefits for diabetes.
    Frontiers in Pharmacology 11/2015; 6. DOI:10.3389/fphar.2015.00260 · 3.80 Impact Factor
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    ABSTRACT: Objective: Asthma and abdominal aortic aneurysms (AAA) both involve inflammation. Patients with asthma have an increased risk of developing AAA or experiencing aortic rupture. This study tests the development of one disease on the progression of the other. Approach and results: Ovalbumin sensitization and challenge in mice led to the development of allergic lung inflammation (ALI). Subcutaneous infusion of angiotensin II into mice produced AAA. Simultaneous production of ALI in AAA mice doubled abdominal aortic diameter and increased macrophage and mast cell content, arterial media smooth muscle cell loss, cell proliferation, and angiogenesis in AAA lesions. ALI also increased plasma IgE, reduced plasma interleukin-5, and increased bronchioalveolar total inflammatory cell and eosinophil accumulation. Intraperitoneal administration of an anti-IgE antibody suppressed AAA lesion formation and reduced lesion inflammation, plasma IgE, and bronchioalveolar inflammation. Pre-establishment of ALI also increased AAA lesion size, lesion accumulation of macrophages and mast cells, media smooth muscle cell loss, and plasma IgE, reduced plasma interleukin-5, interleukin-13, and transforming growth factor-β, and increased bronchioalveolar inflammation. Consequent production of ALI also doubled lesion size of pre-established AAA and increased lesion mast cell and T-cell accumulation, media smooth muscle cell loss, lesion cell proliferation and apoptosis, plasma IgE, and bronchioalveolar inflammation. In periaortic CaCl2 injury-induced AAA in mice, production of ALI also increased AAA formation, lesion inflammation, plasma IgE, and bronchioalveolar inflammatory cell accumulation. Conclusions: This study suggests a pathological link between airway allergic disease and AAA. Production of one disease aggravates the progression of the other.
    Arteriosclerosis Thrombosis and Vascular Biology 11/2015; DOI:10.1161/ATVBAHA.115.305911 · 6.00 Impact Factor
  • Yi Wang · Xiaodong Chen · Xiaojie Chen · Daoyin Yu ·
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    ABSTRACT: Background: In OCT system, the chromatic dispersion of sample decreases the resolution and increases the depth misplacement. The developed numerical dispersion compensation techniques usually do not consider the higher order dispersion and time-consuming. Objective: We proposed a numerical compensation technique for correcting depth error and resolution deterioration in Fourier domain optical coherence tomography (FD-OCT). Methods: Firstly, the rough depth of each scatter in multilayer sample is estimated through magnification curve. Then the depth of a scatter is iterated to minimum the residual of this scatter in the time domain. At last, the spectrum of the scatter is reconstructed and dispersion can be compensated with the tracked depth. Results: The results show that the depth error is corrected to less than resolution level and the resolution is corrected to nearly ideal. Conclusions: The technique proposed can provide precise sample tomography, thus enhancing the understanding of sample character.
    Journal of X-Ray Science and Technology 09/2015; 23(5):639-646. DOI:10.3233/XST-150516 · 1.40 Impact Factor
  • Xinping Ren · Yong Wang · Yi Wang · Hong Chen · Li Chen · Yi Liu · Chengshi Xue ·
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    ABSTRACT: Objective: To investigate the efficacy of transcranial color Doppler ultrasound (TCCS) combined with microbubbles (MBs) and rt-PA (recombinant tissue plasminogen activator) for thrombolysis in vivo. Methods: An arterial embolization model was established in Sprague-Dawley rats by retrograde placement of autologous thrombi into the common carotid artery followed by ligation of external carotid artery and temporary occlusion of the carotid artery and internal carotid artery by clamping. The animals were divided into 5 groups with 6 rats in each group: ① untreated control group, ② rt-PA group, ③ TCCS+MBs group, ④ TCCS+MBs+rt-PA group, ⑤ TCCS+MBs+1/2 rt-PA+group. Thrombolytic effects including recanalization rate and recanalization grade were evaluated with grayscale and color Doppler ultrasound post treatment. Examination of histological change in the involved vessel was performed at the end of the experiments. Results: Thrombolysis in terms of recanalization rate and recanalization grade was observed in the treated groups in a time-dependent manner, except the TCCS+MBs group. Addition of rt-PA remarkably enhanced the therapeutic lysis in TCCS+MBs group. However, no difference of therapeutic effects existed between TCCS+MBs+rt-PA group and TCCS+MBs+1/2 rt-PA group. Conclusion: TCCS+MBs combined with rt-PA is a relatively effective approach for ischemic arterial thrombosis with an additive or synergistic effect.
    Thrombosis Research 09/2015; DOI:10.1016/j.thromres.2015.08.027 · 2.45 Impact Factor
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    ABSTRACT: This study aimed to investigate the validity and reliability of the Chinese parent version of the Autism Spectrum Rating Scale (ASRS, 6-18 years) for a general sample of Chinese children. The study involved assessing 1625 community-based subjects aged 6-12 years from four sites (Shanghai, Guangzhou, Changsha, and Harbin city) in China and 211 clinic-based participants aged 6-18 with a confirmed diagnosis of autism spectrum disorders (ASDs). The internal consistency (Cronbach's alpha) ranged from 0.585 to 0.929, and the test-retest reliability (interclass correlations) ranged from 0.542 to 0.749, indicating no significant difference between the two tests at an interval of 2-4 weeks. The construct validity was relatively excellent, and the concurrent validity with the Social Responsiveness Scale (SRS) (Pearson correlations) was 0.732 between the two total scores. Receiver operating characteristics (ROC) analyses showed excellent and comparable discriminant validity of the ASRS with respect to the SRS, with an area under the curve (AUC) of 0.9507 (95% CI: 0.93-0.97) versus 0.9703 (95% CI: 0.96-0.98), respectively. Our data suggested a cutoff ≥60 for the Chinese version of the ASRS, with good accuracy in screening autism symptoms (sensitivity=94.2%, specificity=77%). The Chinese parent version of the ASRS is therefore a reliable and valid tool for screening autistic symptoms in Chinese children in general.
    09/2015; DOI:10.1016/j.psychres.2015.09.003
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    ABSTRACT: Hypoxia inducible factors, including HIF1A and HIF2A, play central roles in response to high-altitude hypoxia and genetic variants of HIF1A or HIF2A were associated with high-altitude sickness or adaptation. However, it remains to determine whether they are associated with tolerance to different levels of high-altitude selection pressure among native Tibetans. We recruited 189 Tibetan subjects living at 2,700 meters (Low level of high altitude, LHA), 197 at 3,200 meters (Middle level of high altitude of high altitude, MHA), 249 at 3,700 meters (High level of high altitude, HHA) and 269 at 4,700 meters (Very high level of high altitude, VHA) and performed association analysis of twelve tSNPs (tagging SNPs) in HIF1A and HIF2A with high-altitude. We found (1) a increasing trend of HIF2A rs5621780-C(18.4%, 15.9%, 32.8% and 31.1%, respectively, in LHA, MHA, HHA and VHA)(P = 3.56E-9); (2) increasing trends of HIF2A rs6756667-A(68.7%, 73.4%, 79.9% and 89.6%), rs7589621- G(74.6%, 77.9%, 83.7%, and 92.1%) and rs1868092-A(64.1%, 67.3%, 75.1% and 84.4%) (P = 3.56E-9, 4.68E-16, 1.17E-13 and 7.09E-14, respectively); (3) a increasing trend of haplotype AG (68.7%, 73.1%, 79.9% and 89.6%) (P = 2.22E-7) which was constructed by rs6756667 and rs7589621; (4) a strong linear correlation between major alleles of rs6756667-A (R2 = 0.997, P = 0.002), rs7589621-G (R2 = 0.994, P = 0.003), rs1868092-A (R2 = 0.985, P = 0.008) and altitude by linear correlation test. The associations between HIF2A variants and different level of high altitude support that extremely high-altitude hypoxia challenge imposes selective effects on HIF2A variants among native Tibetans.
    PLoS ONE 09/2015; 10(9):e0137956. DOI:10.1371/journal.pone.0137956 · 3.23 Impact Factor
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    ABSTRACT: Author Summary Phosphoglycerate kinase (PGK1) catalyzes the reversible phosphotransfer reaction from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP to form 3-phosphoglycerate (3-PG) and ATP. By controlling ATP and 3-PG levels, PGK1 plays an important role in coordinating energy production with biosynthesis and redox balance. In contrast to the extensive investigation of the transcriptional regulation of PGK1, little is known about its post-translational regulation. Here, we report that PGK1 is acetylated at lysine 220 (K220) and this acetylation inhibits PGK1 activity by disrupting the binding with its substrate, ADP. We have identified KAT9 and HDAC3 as the acetyltransferase and deacetylase, respectively, for PGK1. Moreover, we show there is molecular crosstalk between mTOR-mediated HDAC3 S424 phosphorylation and PGK1 K220 acetylation. Our study uncovers a previously unknown mechanism for the insulin and mTOR pathway in regulating glycolytic ATP production and cellular redox potential via HDAC3-mediated PGK1 deacetylation.
    PLoS Biology 09/2015; 13(9):e1002243. DOI:10.1371/journal.pbio.1002243 · 9.34 Impact Factor
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    ABSTRACT: Hypopituitarism is defined as the partial or complete defect of anterior pituitary hormone secretion. Patients with hypopituitarism usually need life-long hormone replacement therapy. However, in this case, we report a patient with panhypopituitarism whose hypothalamus–pituitary–adrenal (HPA) axis function was completely recovered after pregnancy and delivery. In this case study, we reported the case management and conducted a review of literature to identify the possible mechanism of pituitary function recovery. The patient who suffered from secondary amenorrhea was found a nonfunctioning pituitary macroadenoma, and the hormone test showed serum cortisol, FT3, FT4, thyrotropic hormone, and prolactin were at normal range. After surgical removal of the tumor which invasion in the sellar region, the patient had panhypopituitarism confirmed by the routine hormone test. Though spontaneous pregnancy is impossible in female patients with panhypopituitarism, the patient was restored fertility by the help of artificial reproductive techniques. After the confirmation of the pregnancy, levothyroixine was increased to 75 μg daily and readjusted to 150 μg daily before delivery according to the monthly measurement thyroid function. Hydrocortisone 10 mg daily replaced cortisone acetate; the dose was increased according to the symptoms of morning sickness. A single stress dose of hydrocortisone (200 mg) was used before elective cesarean delivery and was tapered to the dose of 10 mg per day in 1 week. Levothyroixine was reduced to 75 μg daily after delivery. During follow-up, her hypothalamus–pituitary–adrenal (HPA) axis function was completely recovered. The peak serum cotisol level could increase to 19.08 μg/dL by insulin-induced hypoglycemia. However, growth hormone remained unresponsive to the insulin-tolerance test, and thyroid hormone still needed exogenous supplementation. Hormone replacement therapy needed closely followed by endocrinologist and multidisciplinary cooperation during the pregnancy of patients with hypopituitarism. This case indicates that the pituitary function may partially recover after pregnancy in panhypopituitarism patients.
    Medicine 09/2015; 94(39):e1607. DOI:10.1097/MD.0000000000001607 · 5.72 Impact Factor
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    ABSTRACT: A strong association between smoking and SCLC is noted whereas the dose–response relationships are less clear. We demonstrate that cumulative smoking of the first 50 pack-years is associated with a sharper increase in SCLC risk. Moreover, although the relationship between smoking and COPD or COPD and SCLC is well-established, no study has investigated the causal pathway among smoking, COPD, and SCLC. Here we reveal the risks of smoking behaviors on SCLC which are partially mediated (up to 7.6%) through COPD. The findings warrant further experimental study to elucidate the mechanisms in this causal pathway.
    09/2015; DOI:10.1016/j.ebiom.2015.09.031
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    ABSTRACT: Background: It has been considered that the detection methods for circulating tumor cells (CTCs) based on epithelial cell adhesion molecule (EpCAM) underestimate the number of CTCs and may miss a metastatic subpopulation with cancer stem cell (CSC) properties. Therefore, we investigated EpCAM-positive and -negative CTCs in non-small cell lung cancer (NSCLC) patients at different stages, assessed the clinical value of these CTCs and explored their capacity in the following CSC model. Methods: CTCs were enriched by the depletion of leukocytes with bi-antibodies using a magnetic bead separation technique and then identified by the expression of EpCAM and cytokeratin 7 and 8 using multi-parameter flow cytometry. We determined the distribution of CTCs classified by the expression of EpCAM in 46 NSCLC patients with stages I to IV, assessed the diagnostic value of these CTCs by longitudinal monitoring in 4 index patients during adjuvant therapy and characterized the stemness of these CTCs by the expression of CXCR4 and CD133 in 10 patients. Results: EpCAM-negative (E-) CTCs were detected to be significantly higher than EpCAM-positive (E+) CTCs in stage IV (p = 0.003). The patients with the percentage of E-CTCs more than 95% (r > 95%) were detected to be significantly increased from 13.3% in stage I-II to 61.1% in stage IV (p = 0.006). Kaplan-Meier analysis indicated that the patients with r > 95% had significantly shorter survival time than those with r ≤ 0.95 (p = 0.041). Longitudinal monitoring of CTCs indicated that the patients with a high percentage of E-CTCs in the blood were not responsive to either chemotherapy or targeted therapy. Further characterization of CTCs revealed that a stem-like subpopulation of CXCR4+CD133+ CTCs were detected to be significantly more prevalent in E-CTCs than that in E+CTCs (p = 0.005). Conclusions: The enrichment of CTCs by the depletion of leukocytes with bi-antibodies is a valuable method for estimating the number of CTCs, which can be potentially applied in predicting the prognosis, monitoring the therapeutic effect of NSCLC patients and further analyzing the biology of CTCs.
    PLoS ONE 08/2015; 10(8):e0137076. DOI:10.1371/journal.pone.0137076 · 3.23 Impact Factor
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    ABSTRACT: Objectives: The purpose was to evaluate whether BI-RADS (the Breast Imaging Recording and Data System) combined with UE (ultrasound elastography) could improve the differentiation and characterization of benign and malignant breast lesions by comparing with BI-RADS. Methods: A total of 1080 patients with 1194 breast lesions were studied retrospectively at 8 different institutions from 3 geographic areas across China (North, South, and West) from June 2010 to March 2012. Each institutional ethic review board approved the study and all patients gave written informed consent. All the cases were examined by conventional US (ultrasonography) and UE prior to ultrasound-guided core biopsy. Performance of BI-RADS and BI-RADS combined with UE were compared in different size groups, age groups and area groups. Results: BI-RADS combined with UE cloud improve the accuracy by 13.2% compared to BI-RADS alone for all lesions, 23.2% for <10mm lesions, 13.3% for ≥10-20mm lesions, 6.3% for ≥20mm lesions, 18.4% for <50 years group, 1.7% for ≥50 years group, 13.7% for northern area group, 17.7% for southern area group and 4.4% for western area group. Conclusions: The help which UE contributed to BI-RADS was greater for breast lesions <10mm and <50 years group.
    European journal of radiology 08/2015; 84(12). DOI:10.1016/j.ejrad.2015.08.015 · 2.37 Impact Factor
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    ABSTRACT: The numbering up of microchannel reactors definitely faces great challenge in uniformly distributing fluid flow in every channel, especially for multiphase systems. A model of stochastic differential equations (SDEs) is proposed based on the experimental data recorded by a long term optical measurement to well quantify the stochastic trajectories of gas bubbles and liquid slugs in parallel microchannels interconnected with two dichotomic distributors. The expectation and variance of each sub flow rate are derived explicitly from the SDEs associated with the Fokker-Planck equation and solved numerically. A bifurcation in the trajectory is found by using the original model, then a modification on interactions of feedback and crosstalk is introduced, the evolutions of sub flow rates calculated by the modified model match well with experimental results. The established methodology is helpful for characterizing the flow uniformity and numbering up the microchannel reactors of multiphase system. This article is protected by copyright. All rights reserved.
    AIChE Journal 07/2015; 61(11). DOI:10.1002/aic.14938 · 2.75 Impact Factor
  • Daixin Ye · Li Wang · Ren Zhang · Baohong Liu · Yi Wang · Jilie Kong ·
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    ABSTRACT: Using environmental wastes to produce energy materials is extremely attractive for economic social development. Herein, sludge flocs (SF), a kind of environmental wastes which are difficult to be disposed, were used as carbon and nitrogen source for the preparation of N-doped mesocellular graphene foam (SF-NMGF) via a simple one-step pyrolysis. Originated from the special composition and structure of SF, the obtained SF-NMGF had large Brunauer-Emmett-Teller surface areas, graphitic frameworks surrounded by ultrathin nanosheets, foam-like mesopores with size centered at about 15 nm, and homogeneous nitrogen incorporation with high percentage (40.5 at%) of graphitic nitrogen. Owing to these unique properties, SF-NMGF showed excellent electrocatalytic activity with 4e as a metal-free catalyst for the oxygen reduction reaction (ORR). Specifically, the prepared SF-NMGF catalyst exhibited high diffusion-limited current, superior durability and better immunity towards methanol crossover for ORR in alkaline solution than a commercial 20 wt% Pt/C catalyst. More importantly, the synthesis of SF-NMGF can be scaled up with low cost, which will be beneficial for both the sludge handling and development of ORR materials.
    06/2015; 3(29). DOI:10.1039/C5TA03060A
  • Yuan-Feng Zhou · Zhong-Wei Qiao · Yi Wang ·

    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 06/2015; 17(6):577-9.
  • Yi Wang · Gao Lin · Zhiqiang Hu ·
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    ABSTRACT: The present paper deals with the hydrodynamic problems of dam-reservoir systems based on the scaled boundary FEM (SBFEM). It provides a novel boundary condition for hydrodynamic pressure simulation on the truncation boundary suited for dam-reservoir interaction analysis. A two-dimensional gravity dam-reservoir system is addressed, where the impounded water is extended to infinity. In the analysis, a truncation boundary is placed at a short distance away from the dam face in the upstream direction to reduce the computational effort. The proposed approach can conveniently consider the water compressibility, the absorption of the reservoir boundary, and the effect of the reservoir geometry. It is applicable to the earthquake excitation either in the stream direction or in the vertical/cross-stream directions. Additionally, it has the potential to extend to the three-dimensional case. Numerical examples are provided to validate the effectiveness of the proposed approach.
    Journal of Engineering Mechanics 05/2015; 141(5):04014150. DOI:10.1061/(ASCE)EM.1943-7889.0000593 · 1.29 Impact Factor
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    ABSTRACT: Purpose The purpose of this study is to determine whether there is a relationship between continuous electroencephalography (EEG) monitoring patterns and prognosis for children with severe brain damage. Patients and Methods The different patterns of EEG were analyzed for 103 children (Glasgow Coma Scale [GCS] score < 8) who were monitored with continuous video-EEG (CVEEG) within 72 hours after the onset of coma. The clinical outcomes were scored and evaluated at hospital discharge by the modified Pediatric Cerebral and Overall Performance Category Scale (PCOPCS). EEG parameters of the different prognosis groups were compared and risk factors for prognosis were identified. Results Of the 103 children, 36 were in the good prognosis group (PCOPCS scores 1 and 2) and 67 were in the poor prognosis group (PCOPCS scores 3-6). The poor prognosis group had the lower proportion of events in reactive EEG patterns and sleep architecture, and a higher proportion of low-voltage events. Multivariate analyses showed that the lower GCS score and no sleep architecture were significantly associated with poor prognosis. Conclusions Comatose children with higher GCS score and sleep architecture have better clinical outcomes in terms of morbidity and mortality. Georg Thieme Verlag KG Stuttgart · New York.
    Neuropediatrics 04/2015; 46(03). DOI:10.1055/s-0035-1548673 · 1.24 Impact Factor
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    ABSTRACT: Pancreatic fistula is a leading cause of morbidity and mortality after pancreaticoduodenectomy. We introduce here a simple, secure and universal technique for pancreaticojejunostomy with a two-layer continuous running suture. We also report on the preliminary results for grades of pancreatic fistulas among patients who underwent this new technique. 51 consecutive cases were successfully performed using this new technique during pancreaticoduodenectomy. The overall morbidity was 29.4%. Only 3 (5.9%) grade B pancreatic fistulas were observed postoperatively, and were successfully treated with conservative management. The time taken to create the pancreatic anastomosis was less than 15 minutes in all cases. In conclusion, this novel pancreatic anastomosis technique is easy and quick to perform, universally applicable, and appears to be a secure technique that reduces pancreatic fistula rates after pancreaticoduodenectomy.
    Hepato-gastroenterology 04/2015; 62(137):184-6. DOI:10.5754/hge13917 · 0.93 Impact Factor
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    ABSTRACT: The use of somatostatin analogues (SAs) following pancreaticoduodenectomy (PD) is controversial. Literature databases were searched systematically for relevant articles. A meta-analysis of all randomized controlled trials (RCTs) evaluating prophylactic SAs in PD was performed. Fifteen RCTs involving 1,352 patients were included. There was a towards reduced incidences of pancreatic fistulas (p = 0.26), clinically significant pancreatic fistulas (p = 0.08), and bleeding (p = 0.05) in prophylactic SAs group. In subgroup analyses, prophylactic somatostatin significantly reduced the incidence of pancreatic fistulas (p = 0.02), with a nonsignificant trend toward reduced incidence of clinically significantly pancreatic fistulas (p = 0.06). Pasireotide significantly reduced the incidence of clinically significantly pancreatic fistulas (p = 0.03). Octreotide had no influence on the incidence of pancreatic fistulas. The current best evidence suggests prophylactic treatment with somatostatin or pasireotide has a potential role in reducing the incidence of pancreatic fistulas, while octreotide had no influence on the incidence of pancreatic fistulas. High-quality RCTs assessing the role of somatostatin and pasireotide are required for further verification. © 2015 S. Karger AG, Basel.
    Digestive surgery 04/2015; 32(3):196-207. DOI:10.1159/000381032 · 2.16 Impact Factor
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    ABSTRACT: A facile co-calcination strategy with simultaneous N-doping, carbon graphitization, and palladium ion (Pd2+) reduction under high temperature was used to derive Pd nanoparticles budded on N-doped ordered mesoporous graphitic carbon nanospheres (Pd/N-MCN). Pd/N-MCN was exploited as a cathode catalyst for the oxygen reduction reaction (ORR). It demonstrated strong stability with a relative current of 95% still persisting after 40 000 s. Most importantly, hybrids exhibited superior methanol tolerance, remaining stable after the addition of 2 M methanol in electrolyte. The outstanding performance of Pd/N-MCN in ORR could be attributed to its ordered mesopores, large surface area, homogeneous budding of abundant Pd active sites, graphitization generated by Pd catalysis, and the synergistic effects of Pd nanoparticles strongly coupled to N-MCN.
    Electrochimica Acta 04/2015; 160:306-312. DOI:10.1016/j.electacta.2015.01.157 · 4.50 Impact Factor

Publication Stats

8k Citations
976.40 Total Impact Points


  • 2009-2015
    • Chinese Academy of Sciences
      • Institute of Applied Ecology
      Peping, Beijing, China
    • Nanjing University
      Nan-ching, Jiangsu Sheng, China
  • 2006-2015
    • Fudan University
      • • Department of Neurology
      • • Department of Chemistry
      • • School of Pharmacy
      • • Institutes of Biomedical Sciences
      • • School of Life Sciences
      • • Department of Electronic Engineering
      Shanghai, Shanghai Shi, China
  • 2005-2015
    • Tianjin University
      • School of Precision Instrument and Opto-Electronics Engineering
      T’ien-ching-shih, Tianjin Shi, China
  • 2003-2015
    • Second Military Medical University, Shanghai
      • Department of Anesthesiology
      Shanghai, Shanghai Shi, China
  • 2014
    • Zhejiang University
      • State Key Lab of Modern Optical Instrumentation
      Hang-hsien, Zhejiang Sheng, China
    • China-Japan Friendship Hospital
      Peping, Beijing, China
    • Brigham and Women's Hospital
      • Department of Medicine
      Boston, Massachusetts, United States
    • Lanzhou University Second Hospital
      Kao-lan-hsien, Gansu Sheng, China
  • 2012-2014
    • Nanjing General Hospital
      Nan-ching, Jiangsu Sheng, China
    • Peking University People's Hospital
      Peping, Beijing, China
  • 2012-2013
    • Kunming Institute of Zoology CAS
      • State Key Laboratory of Genetic Resources and Evolution
      Yün-nan, Yunnan, China
  • 2007-2013
    • Shanghai Jiao Tong University
      • • School of Medicine
      • • Department of Orthopaedics
      • • Institute of Medical Genetics
      Shanghai, Shanghai Shi, China
    • Sun Yat-Sen University Cancer Center
      Shengcheng, Guangdong, China
    • Nereus Life Science
      Medway, Massachusetts, United States
  • 2005-2013
    • Chinese National Human Genome Center at Shanghai
      Shanghai, Shanghai Shi, China
  • 2011-2012
    • Baylor College of Medicine
      • Human Genome Sequencing Center
      Houston, Texas, United States
  • 2010-2012
    • Dalian University of Technology
      • School of Civil & Hydraulic Engineering
      Lü-ta-shih, Liaoning, China
    • Nanjing Medical University
      Nan-ching, Jiangsu Sheng, China
    • Government of the People's Republic of China
      Peping, Beijing, China
  • 2004-2011
    • Sun Yat-Sen University
      • • State Key Laboratory of Oncology
      • • Department of Hepatobiliary Surgery
      Shengcheng, Guangdong, China
  • 2008
    • Peking University
      Peping, Beijing, China
  • 2003-2006
    • Peking Union Medical College Hospital
      Peping, Beijing, China
  • 2003-2004
    • Chinese Academy of Medical Sciences
      Peping, Beijing, China