L Cordero Di Montezemolo

Publications (2)2.07 Total impact

• Article: Ghrelin and Obestatin in Infants, Lactating Mothers and Breast Milk.

  F Savino, S Benetti, M M Lupica, E Petrucci, E Palumeri, L Cordero di Montezemolo
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  ABSTRACT: Aim: To investigate the role of ghrelin and obestatin in infancy. Methods: We measured ghrelin and obestatin concentrations in blood samples of infants, lactating mothers, and in breast milk. Results: The median (interquartile range) serum ghrelin concentrations were 922.11 (868.44) pg/ml in infants, 667.88 (942.78) pg/ml in lactating mothers, and 526.4 (439.86) pg/ml in breast milk. The serum obestatin levels were 844.87 (805.14) pg/ml in infants, 759.105 (855.55) pg/ml in lactating mothers, and 846.6 (472.07) pg/ml in breast milk. A positive correlation was found for serum ghrelin concentrations in breastfed infants and lactating mothers (p < 0.001, r = 0.789), serum ghrelin concentrations in breastfed infants and in breast milk (p < 0.001, r = 0.581), serum ghrelin concentrations in lactating mothers and in breast milk (p = 0.021, r = 0.450), and serum obestatin concentrations in breastfed infants and in lactating mothers (p = 0.047, r = 0.609). Conclusion: We report for the first time the serum obestatin concentrations in infants and confirm the presence of correlations between ghrelin and obestatin in lactating mothers and breast milk. The correlations found early in infants' life, when hormones begin to exert their effects on feeding behavior, suggest that they may be involved in these processes.
  Hormone Research in Paediatrics 12/2012;
• Article: Adiponectin in breast milk: relation to serum adiponectin concentration in lactating mothers and their infants.

  F Savino, M M Lupica, S Benetti, E Petrucci, S A Liguori, L Cordero Di Montezemolo
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  ABSTRACT:   The aims of the study were to determine human breast milk adiponectin concentration and to investigate its relationship with serum adiponectin concentration in lactating mothers and their infants and also to evaluate the relationship between serum adiponectin concentration and anthropometric parameters in nurses and infants.   We enrolled 60 healthy term breastfed (BF) infants and their lactating mothers. Adiponectin was determined by radioimmunoassay test in serum and by enzyme-linked immunosorbent assay test in human milk (HM). Infants' and mothers' anthropometric parameters were measured.   Median (25‰, 75‰) adiponectin concentration in HM was 9.99 (3.59, 20.52) ng/mL. Serum adiponectin concentration in infants was 60.49 (45.76, 74.24) μg/mL and in lactating mothers 21.14 (12.61, 29.66) μg/mL. Adiponectin concentration in HM correlated positively with adiponectin in mothers' serum; r = 0.60 (p < 0.001) and in infants' serum r = 0.37 (p = 0.015). Adiponectin in HM correlated negatively with infants' age r = -0.3 (p = 0.04). Infants' serum adiponectin correlated negatively with their weight r = -0.35 (p = 0.005), length r = -0.35 (p = 0.006) and age r = -0.46 (p < 0.001) and mothers' serum adiponectin with their weight r = -0.37 (p = 0.02) and body mass index r = -0.45 (p = 0.004).   The observed correlations between adiponectin in mothers, HM and BF infants may be suggestive for a metabolic link between nurses and infants through milk.
  Acta Paediatrica 05/2012; 101(10):1058-62. · 2.07 Impact Factor