Saowaluck Srihongthong

Khon Kaen University, Khon Kaen, Changwat Khon Kaen, Thailand

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Publications (1)1.13 Total impact

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    ABSTRACT: Hemoglobin, α-chain, β-chain and fragmented hemoglobin of Crocodylus siamensis demonstrated both antibacterial and antioxidant activities. Antibacterial and antioxidant properties of the hemoglobin did not depend on the heme structure but could result from the compositions of amino acid residues and structures present in their primary structure. Furthermore, thirteen purified active peptides were obtained by RP-HPLC analyses, corresponding to fragments in the α-globin chain and the β-globin chain which are mostly located at the N-terminal and C-terminal parts. These active peptides operate on the bacterial cell membrane. The globin chains of Crocodylus siamensis showed similar amino acids to the sequences of Crocodylus niloticus. The novel amino acid substitutions of α-chain and β-chain are not associated with the heme binding site or the bicarbonate ion binding site, but could be important through their interactions with membranes of bacteria.
    The Protein Journal 05/2012; 31(6):466-76. · 1.13 Impact Factor

Publication Stats

4 Citations
1.13 Total Impact Points

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Institutions

  • 2012
    • Khon Kaen University
      • Faculty of Sciences
      Khon Kaen, Changwat Khon Kaen, Thailand