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Publications (2)2.99 Total impact

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    ABSTRACT: Scolopendra subspinipes mutilans L. Koch has been used for cancer treatment in traditional Chinese medicine for hundreds of years. In this study, the effects of a polysaccharide-protein complex from Scolopendra subspinipes mutilans L. Koch (SPPC) on the tumor growth and immune function were assessed in sarcoma S180 and hepatoma H22 bearing mice. Results showed that SPPC significantly inhibited the growth of S180 transplanted in mice and prolonged the survival time of H22- bearing mice. In S180-bearing mice, it promoted specific and nonspecific immune response as evidenced by enhancing the activities of natural killer (NK) cells, cytotoxic T lymphocytes (CTL) and the ratio of Th1/Th2 cytokines, and increasing the percentages of CD4(+) T cells, B cells and NK cells. Furthermore, SPPC not only significantly inhibited mRNA expression and production of the immunosuppressive cytokines (IL-10 and TGF-β), but also diminished arachidonic acid (AA)-metabolizing enzymes (COX-2 and CYP4A) and their products (PGE(2) and 20-HETE) in tumor-associated macrophages (TAMs). Taken together, our results indicate that SPPC inhibits tumor growth in vivo by improving antitumor immune responses at least partly via downregulating AA-metabolic pathways in TAMs, and could act as an anti-tumor agent with immunomodulatory activity.
    Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 05/2012; 50(8):2648-55. · 2.99 Impact Factor
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    ABSTRACT: Cytochrome P450s (CYP) ω-hydroxylase and its metabolites 20 - hydroxyeicosatetraenoic acid (20-HETE) play an important role in the central nervous system disorders. The purpose of this study was to determine the effects of the 20-HETE inhibitor, HET0016, on myelin sheath after demylination in mice. Methods: We have studied the impact of HET0016 on remyelination using the toxic cuprizone model. Animals were assigned randomly to various groups and injected intraperitoneally with 10% lecithin or 2.0 and 0.2 mg/kg of HET0016 per day in 2 weeks. The animals were killed and the brains were reserved. We investigated spatial memory of mice using the Y-maze. We observed the myelin of corpus callosum by histochemical staining. Results: there were no significant differences in body weight, food intake and water intake between the model group and HET0016 (2.0mg/kg, 0.2mg/kg) group; spatial memory improved significantly in HET0016 (0.2mg/kg, 2.0mg/kg) group compared with model group; corpus callosum structure was significantly remyelinated after 2 weeks by HET0016 treatment. Conclusion: HET0016, a selective inhibitor of CYP ω-hydroxylase, has potent therapeutic effect on multiple sclerosis mice.
    01/2012;