[Show abstract][Hide abstract] ABSTRACT: To investigate demographic, socioeconomic, lifestyle, and medical factors that might predispose women to cervical human papillomavirus (HPV) infection.
A cross-sectional population-based study was performed. Women aged 18-64 years who attended selected obstetrics and gynecology or sexually transmitted disease (STD) clinics in mainland Portugal between February 2008 and March 2009 were recruited, according to an age-stratified sampling strategy. Liquid-based cytology samples were analyzed centrally for HPV genotype and for cytologic features. Univariate and multivariate logistic regression analyses identified risk factors for HPV infection.
Among the 2326 women evaluated, the crude prevalence of HPV infection was 19.4%. Lifetime number of sexual partners was a strong predictor of HPV infection (odds ratio 5.44 for 5-10 partners versus 1 partner; P<0.001). Other risk factors were young age (particularly among women aged 20-24 years; P<0.001); country of birth other than mainland Portugal (P=0.002); education up to secondary school level (P=0.010); smoking history (≤ 10 years; P=0.004); and any STD in the past 12 months (P=0.052).
Data from the present study may aid identification of women at increased risk of HPV infection and target prevention strategies. Trial registration: National Commission of Data Protection (CNPD) registration number 5346/2007; Sanofi Pasteur MSD study number HPV-E05.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 05/2012; 118(2):112-6. · 1.41 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Metastasization of breast cancer involves various mechanisms responsible for progression from invasive lesion to dissemination in distant organs. Regional lymph node metastasization was considered an initial step in this process, but it is now recognized that hematogenous dissemination is a deviation from lymphatic circulation. The detection of circulating tumor cells (CTC) is an aim in several oncology areas. For this purpose, several techniques have been used to detect CTC, including the use of antibodies and techniques with nucleic acids. This study reviews the published studies considering the detection of breast cancer CTC. There are focused the difficulties in identifying a CTC in a heterogeneous population, the handling of the sample, criteria of positivity, analytical techniques, and specific markers. There are systematized various specific markers of breast cancer cells also the problems with false positive results. Finally, we hypothesize clinical applications either as a prognostic marker or as a therapeutic response monitor.
[Show abstract][Hide abstract] ABSTRACT: The aim of this study is to evaluate epidermal growth factor receptor variant III, EGFRvIII, a cancer specific mutant, as a possible marker for the diagnosis of breast cancer occult systemic disease. EGFRvIII mRNA was identified by an RT-nested PCR with a high sensitivity. In 102 women studied, the mutant was detected in the peripheral blood of 30% of 33 low risk, early stage patients, in 56% of 18 patients selected for neoadjuvant chemotherapy, in 63.6% of 11 patients with disseminated disease and 0% of 40 control women. In low risk, early stage patients, the presence of one or more tumour characteristics predicting recurrence such as the absence of oestrogen receptors and the presence of ERBB2 or histologic grades G2/G3 was significantly associated with EFGRvIII detection (p<0.05). EGFRvIII mRNA has characteristics to be a useful marker for the diagnosis of occult systemic disease in breast cancer. Follow-up studies will evaluate its clinical value as a decision criterion for systemic therapy.
European Journal of Cancer 11/2006; 42(15):2617-22. · 5.06 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: In the last few years, ovarian ablation with GnRH agonists has been used as first-line adjuvant therapy in pre and perimenopausal breast cancer. These drugs suppress ovarian function in the hypothalamic-pituitary axis and they have adverse effects in other end-organs. A retrospective study was conducted on 35 premenopausal women, with breast cancer, and treated with goserelin, in order to investigate the effects of iatrogenic estrogen suppression. All women complaint of amenorrhea and only half of them referred hot-flashes, weight gain or arthralgias. Hot-flushes and arthralgias remit spontaneously in the end of the treatment. Osteodensitometry was used to access bone mass. There was a reduction in mineral bone mass and T-score at femoral neck and lumbar spine after the treatment with goserelin, but without statistical significance, except for the T-score in lumbar spine.
[Show abstract][Hide abstract] ABSTRACT: The bibliometric analysis of the Portuguese scientific production in the field of breast pathology since 1995 to date (July 2005) provides an overview on the developed scientific activity on this subject and allows the characterisation of some relevant features as well as its evolution along the studied period.
Documents collected, reflecting the national scientific production in the field of breast pathology between 1995 and July 2005 in 3 databases, Medline (with search interface PubMed), Science Citation Index and Index of the Portuguese medical journals were studied. We applied quantitative and qualitative bibliometric indicators to the found number of articles and the journals where they were published. The quantitative indicators based on the number of published articles illustrate Portugal's position in the area of breast pathology within the international scientific community; further, it also allows the identification of the participation of the different institutions and national bodies, allocated by geographic areas, in scientific production as well as the establishment of international collaboration. Qualitative indicators were used to investigate the influence, and the impact of the scientific production. These are indicators based on the journal classification where the articles were published and also the citations they received. The number of citations obtained by the articles collected in the performed search, was determined, based on the Science Citation Index and the Impact Factor (IF) of the journals, which is annually published in the Journal Citation Reports (JCR). In spite of all its constraints, it is difficult not to accept the opinion that the Impact Factor is today one of the few means (if not the sole one) which enables an assessment of the influence of a journal in the international scientific community.
During the evaluated period, the Portuguese scientific production in the selected area showed an increase of 200%. We analysed 348 documents (232 published in the selected international Databases and 16 in the national Database. We noticed that articles published by one single author are very rare, n=6 and that co-authorship is the most common way of publishing. The distribution of article production is as follows: 59% in the North Zone, 26% in the South Zone and 15% in the Central Zone of the country. The national institutions with a higher rate of publishing in renowned international journals are IPATIMUP, IPO Porto and IPO Lisboa. The institutions which publish the larger number of papers in Portuguese journals are Hospitals and Health Centres. The international journals selected by the national scientists present a high impact factor. In the whole of the 232 articles selected in the international databases, 81 have not received any citation and 120 obtained a total of 1.856 citations. It should be noted that the more recent articles have not yet received citations. The articles resulting from international collaboration, were those receiving an higher rate of citations.
An increase of the investigation in breast pathology is observed, this being illustrated by the increase in the number of articles published in well-recognized international journals. It is also noticed a trend to publish in journals with a higher impact factor as well as an increasing role of co-authorship and international collaboration.
[Show abstract][Hide abstract] ABSTRACT: Nos últimos anos a castração médica com análogos da GnRH (gonadotrophin-releasing hormone) tem sido uma opção de primeira linha na terapêutica adjuvante do cancro da mama em mulheres pré e peri-menopáusicas. Estes fármacos têm um efeito frenador da função ovárica a nível central pelo que não estão isentos de efeitos secundários em vários órgãos-alvo. Uma série de 35 mulheres pré-menopáusicas, com cancro da mama, submetidas a terapêutica com goserelina, foi alvo de um estudo retrospectivo, para avaliar a sintomatologia relacionada com a falência ovárica iatrogénica. A amenorreia foi um sintoma referido por todas as doentes, enquanto que a sintomatologia vaso-motora, o aumento ponderal e as osteoartralgias foram referidas por metade das pacientes que integraram o estudo. Houve remissão da sintomatologia vaso-motora e das osteoartralgias, no final do tratamento. As repercussões sobre a massa óssea foram estudadas por osteodensitometria. Verificou-se uma redução da densidade mineral óssea e do score T no colo do fémur e coluna lombar, após o tratamento com goserelina, apenas com significado estatístico para o score T na coluna lombar. Palavras-chave: Análogos da GnRH, cancro da mama, castração médica DRAWBACKS OF OVARIAN ABLATION WITH GOSERELIN In women with breast cancer In the last few years, ovarian ablation with GnRH agonists has been used as first-line adjuvant therapy in pre and perimenopausal breast cancer. These drugs suppress ovarian function in the hypotalamic-pituitary axis and they have adverse effects in other end-organs. A retrospective study was conducted on 35 premenopausal women, with breast cancer, and treated with goserelin, in order to investigate the effects of iatrogenic estrogen supression. All women complaint of amenorrhea and only half of them referred hot-flushes, weight gain or arthralgias. Hot-flushes and arthralgias remit spontaneously in the end of the treatment. Osteodensitometry was used to access bone mass. There was a reduction in mineral bone mass and T-score at femoral neck and lumbar spine after the treatment with goserelin, but without statistical significance, except for the T-score in lumbar spine.
[Show abstract][Hide abstract] ABSTRACT: the scientific production of Portuguese institutions in the specific field Oncology during a 10 year period (1997-2006) was evaluated. The contribution of national authors to the international scientific production was verified. This enabled to assess and quantify the importance of authors, departments, institutions and scientific investigations.
Using version 2006 of Web of Science, section Science Citation Index, a database of literature references which enables analysis of citations, and also the Journal Citation Reports (tools produced by ISI Thomson Scientific), a quantitative and qualitative analysis of the Portuguese scientific production on cancer between 1997 to 2006 was performed.
during the studied period, 1.384 articles were published in scientific journals with given impact factor, which obtained a total of 16.484 citations, corresponding to a mean of 11.91 citations per article. Between 1997 and 2006 an increase of 214% was noticed in the national scientific production in the selected field. Ten authors represent 46% of the produced documents. The majority of published articles were performed by Universities, being Oporto University the one with highest contribution. Co-authorship is the rule in the production of articles and Portugal is no exception. Articles with international collaboration where those which obtained the highest citation rate. The Portuguese contribution to the international scientific production in the field of Oncology in the studied period was of 0.21%.
Bibliometric analysis is a reliable tool to evaluate the development and quality of scientific production. A growing visibility of investigation in this area was observed. This conclusion is based on the increase in the number of articles published in international journals of recognized reputation. National authors publish few articles, but they select high standard journals.