Lopa K Pandya

Saint Louis University, Сент-Луис, Michigan, United States

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Publications (3)6.55 Total impact

  • Pankaj Dangle · Lopa Pandya · Michael Chehval
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    ABSTRACT: The majority of patients presenting with renal and/or peri-renal hemorrhage are diagnosed with an underlying etiology. Non-traumatic spontaneous idiopathic renal hemorrhage is an infrequently reported entity. Management of these patients is critical; diagnosis is established only once any surgically correctable etiology is excluded. A 57 year old Caucasian female with no significant past medical history presented to an outside emergency department with a one day history of right lower back pain and fatigue. An abdominal and pelvic computed tomography (CT) at the time revealed a grade IV right renal laceration. We present this unusual case of a previously healthy woman with a low probability for a spontaneous idiopathic non traumatic grade IV renal laceration with perirenal hemorrhage. Though most renal and perirenal hemorrhages are associated with an underlying etiology, in rare circumstances idiopathic non traumatic spontaneous renal laceration manifests with insignificant symptomatology. It is critical for clinicians in the Emergency Department to be aware of this entity to avoid diagnostic error. Prior to categorizing an injury as idiopathic, appropriate evaluation to rule out rare etiologic basis is crucial.
    The West Virginia medical journal 03/2013; 108(6):24-6.
  • BJU International 06/2012; 109(12):1872-4. DOI:10.1111/j.1464-410X.2012.11253.x · 3.53 Impact Factor
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    Praneetha Thulasi · Lopa K Pandya · Brent M Znosko
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    ABSTRACT: Relatively few thermodynamic parameters are available for RNA triloops. Therefore, 24 stem-loop sequences containing naturally occurring triloops were optically melted, and the thermodynamic parameters ΔH°, ΔS°, ΔG°(37), and T(M) for each stem-loop were determined. These new experimental values, on average, are 0.5 kcal/mol different from the values predicted for these triloops using the model proposed by Mathews et al. [Mathews, D. H., Disney, M. D., Childs, J. L., Schroeder, S. J., Zuker, M., and Turner, D. H. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 7287-7292]. The data for the 24 triloops reported here were then combined with the data for five triloops that were published previously. A new model was derived to predict the free energy contribution of previously unmeasured triloops. The average absolute difference between the measured values and the values predicted using this proposed model is 0.3 kcal/mol. These new experimental data and updated predictive model allow for more accurate calculations of the free energy of RNA stem-loops containing triloops and, furthermore, should allow for improved prediction of secondary structure from sequence.
    Biochemistry 10/2010; 49(42):9058-62. DOI:10.1021/bi101164s · 3.02 Impact Factor