Han Wen

Publications (2)0 Total impact

• Article: [Effects of overweight and obesity on physical function among children and adolescents: a multilevel analysis].

  Lian-guo Fu, Jun Ma, Hai-jun Wang, Bin Dong, Jing-jing Wang, Xiao-rui Shang, Zi-long Zhang, Fang-hong Liu, Ci-he Cai, Han Wen
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  ABSTRACT: To analyze the influence of overweight and obesity on body function among children and adolescents using a multilevel model, and to provide the basis for understanding their influence. According to the "Reference Norms for Screening Overweight and Obesity in Chinese Children and Adolescents" set up by Working Group Obesity in China (WGOC) in 2003, we screened out individuals with overweight and obesity from the data obtained from the body and health survey of Chinese children and adolescents in 2005. The samples of the non-overweight group and the overweight group were randomly selected from the screened data by 1:1 match with samples of the obesity group by gender and city/rural area, then underwent the multilevel model to explore the influence of overweight and obesity on body function. The single dependent variable model showed that the overweight group had significant increases in systolic blood pressure (SBP) and diastolic blood pressure (DBP) by 5.25 mmHg (1 mmHg=0.133 kPa) and 3.44 mmHg, respectively (P<0.01), when compared with the non-overweight group. There were no significant differences between the overweight and non-overweight groups in pulse and vital capacity (VC) (P>0.05), and the obesity group had significant increases in SBP, DBP, pulse and VC by 10.15 mmHg, 6.34 mmHg, 1.44 times/min and 390.04 mL, respectively (P<0.01), when compared with the non-overweight group. The multiple dependent variables model showed that the SBP, DBP and pulse of the overweight group and obesity group were significantly greater than those of non-overweight group (P<0.01). There was a significant difference between the overweight group and non-overweight group in VC (P<0.05), yet the same result was not found between the obesity group and non-overweight group (P>0.05). Overweight and obesity may cause a decline in body function among children and adolescents, and obesity has a more obvious influence on body function.
  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 06/2012; 44(3):359-63.
• Article: [Relationship between serum visfatin level and children and adolescent obesity and non-alcoholic fatty liver disease].

  Han Wen, Hai-jun Wang, Bin Dong, Jun Ma
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  ABSTRACT: To examine the relationships between the level of serum visfatin and obesity, nonalcoholic fatty liver disease (NAFLD) in children and adolescents. Serum visfatin levels of 106 obese children/adolescents (including 49 non-NAFLD children and adolescents and 57 NAFLD children/adolescents in which consisting of 42 mild ones, 15 moderate-to-severe ones) with another 69 lean children/adolescents as their controls, were examined by indirect sandwich ELISA. When comparing the serum visfatin levels, there was no significant difference noticed between the obese group (1.71±0.37) ng/ml and the lean group (1.75±0.37) ng/ml (P=0.455). With the severity of NAFLD, the serum visfatin level showed an elevation in obese children and adolescents [obese without NAFLD (1.59±0.36) ng/ml, obese with mild NAFLD (1.74±0.36) ng/ml, obese with moderate-to-severe NAFLD (1.97±0.36) ng/ml, P<0.05]. In the obese group, serum visfatin levels seemed to be related to age (β=-0.326, P=0.000), alanine aminotransferase (ALT) (β=0.286, P=0.004) and the degree of NAFLD (β=0.246, P=0.014). The level of serum visfatin was related to non-alcoholic fatty liver in obese children and adolescent.
  Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 03/2012; 33(3):269-72.