Anita Achan

University of Western Sydney, Penrith, New South Wales, Australia

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Publications (7)12.34 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Aim: To report a case of metastatic small-cell neuroendocrine carcinoma presenting as an isolated choroidal mass and initially misdiagnosed as a circumscribed choroidal hemangioma. Methods: The clinical history, fundus findings, imaging, cytology and immunohistochemical features are described. Results: An otherwise healthy 66-year-old man was referred for a left nasal scotoma and a diagnosis of circumscribed choroidal hemangioma. Cytology showed cohesive clusters of small-to-intermediate malignant cells. The atypical cells stained positively for chromogranin, thyroid transcription factor-1 and synaptophysin consistent with small-cell neuroendocrine carcinoma. Conclusion: Small-cell neuroendocrine carcinoma metastatic to the choroid is extremely rare; however, it is particularly aggressive and should be included in the differential diagnosis of isolated choroidal lesions, even in otherwise healthy patients.
    06/2015; 2(1):13-15. DOI:10.1159/000382024
  • Valli Thanni · Anita Achan · Hedley G. Coleman
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    ABSTRACT: Carcinoma ex-Pleomorphic adenoma is defined as a carcinoma that arises in the epithelial and/or myoepithelial component of a pleomorphic adenoma. Prognosis and management is highly dependent on the type of carcinoma and extent of invasion. The malignant component is classified as non-invasive (intracapsular), minimally invasive, and widely invasive. Non-invasive and minimally invasive tumours have an excellent prognosis and very low metastatic potential. This case study is of a 59-year-old man with a tumour in the Thoracic 9 vertebra that was compressing the spinal cord. Multiple tissue fragments were sent to our department for frozen tissue assessment which microscopically showed a tumour with features resembling carcinoma ex-pleomorphic carcinoma with a malignant component suggestive of myoepithelial carcinoma. This was confirmed with immunohistochemistry done on further samples of the tumour. The patient was discovered in our databases to have had a previous left parotidectomy in 2008 for a carcinoma ex pleomorphic adenoma with features similar to the frozen section tissue. The clinicians involved with this case had no knowledge of this. This case, whilst rare, highlights the importance of the pathologist's role in diagnosis and patient management.
    Pathology 02/2014; 46:S83. DOI:10.1097/01.PAT.0000443623.41002.ee · 2.62 Impact Factor
  • Kyaw Lynnhtun · Anita Achan · Vincent Lam
    Pathology 07/2013; 45(5). DOI:10.1097/PAT.0b013e32836359a9 · 2.62 Impact Factor
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    ABSTRACT: Benign vascular lesions have a diverse appearance and can be extremely difficult to classify. We present renal anastomosing hemangiomas from 2 patients that exemplify the potential diverse range of appearances that can occur in this recently described, rare variant of capillary hemangioma. The lesion from one patient was an intravenous hemangioma with closely packed, fenestrated vascular channels that were reminiscent of the splenic red pulp. Also, the endothelial cells contained hyaline globules. On the other hand, the second patient had multifocal tumor. The lesions showed more extensive hyalinization and vascular ectasia reminiscent of cavernous hemangioma. Extramedullary hematopoiesis was a feature in all the tumors, particularly in the second patient where numerous immature blasts were present within vascular spaces.
    International Journal of Surgical Pathology 07/2013; 22(4). DOI:10.1177/1066896913492850 · 0.96 Impact Factor
  • S Kemp · A Achan · T Ng · M A J Dexter
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    ABSTRACT: We report a 33-year-old man with neurofibromatosis type 1 (NF-1) with a rosette-forming glioneuronal tumour (RGNT) in the lateral ventricle. The patient had been treated with radiotherapy and chemotherapy for a typical juvenile pilocytic astrocytoma of the hypothalamus seven years prior. MRI revealed a contrast-enhancing mass in the anterior horn of the left lateral ventricle. Histological examination demonstrated two distinct regions characterised by a rosette-forming neurocytic component and an astrocytic predominant component. Immunohistochemical studies showed glial fibrillary acidic protein and S-100 positivity in the astrocytic component and neuron-specific enolase was positive in the neurocytic cells. Although RGNT has been reported at other sites within the central nervous system, this report documents a previously undescribed lateral ventricular location of a rare RGNT in an asymptomatic patient with NF-1.
    Journal of Clinical Neuroscience 05/2012; 19(8):1180-1. DOI:10.1016/j.jocn.2011.12.013 · 1.32 Impact Factor
  • Histopathology 03/2012; 60(7):1156-8. DOI:10.1111/j.1365-2559.2011.04173.x · 3.30 Impact Factor
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    ABSTRACT: Plexiform fibrohistiocytic tumor is a rare soft tissue tumor that has a propensity to occur in the extremities in adolescents and young adults. Its cytologic features are not well documented, with only two case reports available in the literature. We present the case of a recurrent plexiform fibrohistiocytic tumor in a 19-year-old male, the cytologic features of which mimic that of a high-grade sarcoma. We discuss the likely differential diagnosis based on the cytologic findings and a review of the current literature on this highly unusual tumor is also performed.
    Diagnostic Cytopathology 01/2011; 39(1):49-53. DOI:10.1002/dc.21371 · 1.52 Impact Factor

Publication Stats

4 Citations
12.34 Total Impact Points

Institutions

  • 2013
    • University of Western Sydney
      Penrith, New South Wales, Australia
  • 2011–2013
    • Westmead Hospital
      • Department of Tissue Pathology
      Sydney, New South Wales, Australia