Azhar Rasul

Northeast Normal University, Hsin-ching, Jilin Sheng, China

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Publications (7)13.1 Total impact

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    ABSTRACT: Tubeimoside-1 (TBMS1) is a triterpenoid saponin with potent anticancer properties. In this study, for the first, we examined the anti-proliferative effects of TBMS1 in human bladder cancer T24 cells and its ability to induce apoptosis and cell cycle arrest. Our results demonstrated that TBMS1 decreased the cell viability of bladder cancer T24 cells in a dose-dependent manner. Flow cytometric analysis showed that TBMS1 significantly triggered apoptosis in T24 cells and arrested cell cycle at G2/M phase in a dose-dependent manner. Further characterization demonstrated that TBMS1-induced apoptosis is associated with dissipation in mitochondrial membrane potential (ΔΨm), down-regulation of Bcl-2, and up-regulation of Bax and p21 in TBMS1-treated T24 cells. These in vitro results suggested that TBMS1 is an effective anti-bladder cancer natural compound that worth further mechanistic and therapeutic studies in human bladder cancer. © 2014 Bangladesh Pharmacological Society. All Rights reserved.
    Bangladesh Journal of Pharmacology 09/2014; 9(4). DOI:10.3329/bjp.v9i4.19989 · 1.05 Impact Factor
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    ABSTRACT: Pinocembrin (5,7-dihydroxyflavanone) is one of the primary flavonoids isolated from the variety of plants, mainly from Pinusheartwood,Eucalyptus, Populus, Euphorbia,andSparattosperma leucanthum, in the diverse flora and purified by various chromatographic techniques. Pinocembrin is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. In addition, pinocembrin can be used as neuroprotective against cerebral ischemic injury with a wide therapeutic time window, which may be attributed to its antiexcitotoxic effects. Pinocembrin exhibits pharmacological effects on almost all systems, and our aim is to review the pharmacological and therapeutic applications of pinocembrin with specific emphasis on mechanisms of actions. The design of new drugs based on the pharmacological effects of pinocembrin could be beneficial. This review suggests that pinocembrin is a potentially promising pharmacological candidate, but additional studies and clinical trials are required to determine its specific intracellular sites of action and derivative targets in order to fully understand the mechanism of its anti-inflammatory, anticancer, and apoptotic effects to further validate its medical applications. 1. Introduction Throughout the history of civilization, natural products have served human beings as a primary source of medicine [1]. The term “natural products” comprises chemical compounds that are derived from living organisms such as plants, fungi, bread molds, microorganisms, marine organisms, and terrestrial vertebrates and invertebrates [2]. In 2008, of the 225 drugs being developed, 164 were of natural origin, with 108 being derived from plants, 25 from bacterial sources, 7 from fungal, and 24 from animal sources, and, to throw some more numbersaround,ofthe108plant-baseddrugs,46wereinpreclinical development, 14 in phase I, 41 in phase II, 5 in phase III, and two had already reached preregistration stage [3]. An analysis of medical indications by resource of compounds has established that natural products and related drugs, including anticancer, antibacterial, antiparasitic, anticoagu
    BioMed Research International 07/2013; Volume 2013:9pages. · 2.71 Impact Factor
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    BioMed Research International 10/2012; · 3.17 Impact Factor
  • Muhammad Khan · Fei Yi · Azhar Rasul · Tonghui Ma
    International Union of Biochemistry and Molecular Biology Life 06/2012; · 3.14 Impact Factor
  • Azhar Rasul · Saima Parveen · Tonghui Ma
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    ABSTRACT: Currently an ample interest is found among oncologists to explore anticancer compounds from herbs. Sesquiterpene lactones have accredited significant attention in pharmacological research. Costunolide is a well-known sesquiterpene lactone present in plants used as popular herbal remedy. Several plant-derived compounds are currently successfully employed in cancer treatment. Growing evidences demonstrated that costunolide possesses anticancer activities by inhibiting cell proliferation, tumor invasion, angiogenesis, metastasis and inducing apoptosis of a variety of tumor cell lines. This review is aimed to summarize the recent researches about costunolide focusing on anti-tumor activity and to lay emphasis on its molecular targets and its mechanisms, which may help the further design and conduct of preclinical and clinical trials.
    International Journal of Oncology 01/2012; DOI:10.3329/bjp.v7i1.10066 · 3.03 Impact Factor