Abeer M Nafee

Publications (1)1.97 Total impact

• Article: Interleukin-4 polymorphisms and response to combination therapy in Egyptian chronic hepatitis C patients.

  Sally M Shalaby, Mohamed I Radwan, Shymaa Abdelazim, Abeer M Nafee
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  ABSTRACT: In hepatitis C infection, the production of inappropriate cytokines levels may contribute to viral persistence and may affect the response to antiviral therapy. We investigate the effect of IL4 C-590T and C-33T polymorphisms on the response to combination therapy with interferon and ribavirin in chronic HCV patients. These single nucleotide polymorphisms were determined by PCR-RFLP in 235 responder and 210 non-responder to combination therapy. The IL4-590 T/T and -33 T/T genotypes were associated with resistance to the therapy (p<0.001, p=0.001 respectively). Haplotypes T(-590) T(-33) and T(-590) C(-33) were associated with a higher risk in non-responder patients than the responders (p<0.001 for each) while frequency of haplotype C(-590) C(-33) (with all wild alleles) was significantly higher in responders as compared to non-responders (p<0.001). These results suggest that inheritance of the IL4 polymorphisms may be associated with resistance to combined antiviral therapy in Egyptian HCV patients.
  Cellular Immunology 04/2012; 276(1-2):110-3. · 1.97 Impact Factor