Divya Seth

Publications (2)4.12 Total impact

• Article: Lipid profiles and risk of breast and ovarian cancer in the Swedish AMORIS study.

  Jennifer C Melvin, Divya Seth, Lars Holmberg, Hans Garmo, Niklas Hammar, Ingmar Jungner, Göran Walldius, Mats Lambe, Annette Wigertz, Mieke Van Hemelrijck
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  ABSTRACT: Obesity is a risk factor for breast and ovarian cancer; the mechanisms of action are not completely understood. Perturbed lipid metabolism often accompanies obesity; we therefore ascertained the associations between lipid components and breast and ovarian cancer risk in a prospective cohort study. A total of 234,494 women with baseline measurements of triglycerides and total cholesterol and glucose were selected from the AMORIS database.A total of 27,394 had measurements of high-density lipoprotein, low-density lipoprotein, apolipoprotein (Apo) B, and A-I. Associations between quartiles and dichotomized values of lipid components and breast and ovarian cancer risk were analyzed using Cox proportional hazard models. We identified 6,105 women diagnosed with breast cancer and 808 women diagnosed with ovarian cancer. A weak trend was observed between triglycerides and breast cancer (HR, 1.01, 95% Confidence Interval, 0.94-1.09; 0.93 (0.86-1.00) 0.91 (0.84-0.99), second, third, and fourth quartiles; P = 0.01). No other associations between lipid components and risk of breast cancer or ovarian cancer showed statistical significance. A weak protective association was found between levels of triglycerides and risk of breast cancer. An analysis including information on tumour characteristics of ovarian cancer and breast cancer may provide more insight in possible links between lipid metabolism and the risk of these cancers.
  Cancer Epidemiology Biomarkers &amp Prevention 05/2012; 21(8):1381-4. · 4.12 Impact Factor
• Article: Lipid profiles and the risk of endometrial cancer in the Swedish AMORIS study.

  Divya Seth, Hans Garmo, Annette Wigertz, Lars Holmberg, Niklas Hammar, Ingmar Jungner, Mats Lambe, Göran Walldius, Mieke Van Hemelrijck
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  ABSTRACT: While the association between obesity and endometrial cancer (EC) is well established, the underlying mechanisms require further study. We assessed possible links between lipid profiles and EC risk, while also taking into account BMI, parity, and menopausal status at baseline. Using the information available from the Swedish Apolipoprotein MOrtality RISk (AMORIS) study we created a cohort of 225,432 women with baseline values for glucose, triglycerides (TG), and total cholesterol (TC). Two subgroups of 31,792 and 26,317 had, in addition, baseline measurements of HDL, LDL, apolipoprotein A-I and apoB and BMI, respectively. We used Multivariate Cox proportional hazards models to analyze quartiles and dichotomized values of these lipid components for a link to EC risk. During mean follow-up of 12 years (SD: 4.15), 1,144 persons developed endometrial cancer. A statistically significant association was found between TG and EC risk when using both quartiles and a clinical cut-off (Hazard Ratio (HR): 1.10 (95%CI: 0.88-1.37), 1.34 (1.09-1.63), and 1.57 (1.28-1.92)) for the 2(nd), 3(rd), and 4(th) quartile, compared to the 1(st), with P-value for trend: <0.001). The association remained after exclusion of the first three years of follow-up. Also total cholesterol and TG/HDL ratio were positively associated with EC risk, but no link was found for the other lipid components studied. This detailed analysis of lipid components showed a consistent relation between TG levels and EC risk. Future research should continue to analyze the metabolic pathway and its relation to EC risk, as a pathway to further understand the relation of obesity and disease.
  International Journal of Molecular Epidemiology and Genetics 01/2012; 3(2):122-33.