Ya-Ling Zhao

Xi'an Jiaotong University, Xi’an, Shaanxi Sheng, China

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Publications (7)3.23 Total impact

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    ABSTRACT: Dopamine D1 receptor (DRD1) modulates opioid reinforcement, reward, and opioid-induced neuroadaptation. We propose that DRD1 polymorphism affects susceptibility to opioid dependence (OD), the efficiency of transition to OD, and opioid-induced pleasure response. We analyzed potential association between seven DRD1 polymorphisms with the following traits: duration of transition from the first use to dependence (DTFUD), subjective pleasure responses to opioid on first use and post-dependence use, and OD risk in 425 Chinese with OD and 514 healthy controls. DTFUD and level of pleasure responses were examined using a semi-structured interview. The DTFUD of opioid addicts ranged from 5 days to 11 years. Most addicts (64.0%) reported non-comfortable response upon first opioid use, while after dependence, most addicts (53.0%) felt strong opioid-induced pleasure. Survival analysis revealed a correlation of prolonged DTFUD with the minor allele-carrying genotypes of DRD1 rs4532 (hazard ratios (HR) = 0.694; p = 0.001) and rs686 (HR = 0.681, p = 0.0003). Binary logistic regression indicated that rs10063995 GT genotype (vs. GG+TT, OR = 0.261) could predict decreased pleasure response to first-time use and the minor alleles of rs686 (OR = 0.535) and rs4532 (OR = 0.537) could predict decreased post-dependence pleasure. Moreover, rs686 minor allele was associated with a decreased risk for rapid transition from initial use to dependence (DTFUD≤30 days; OR = 0.603) or post-dependence euphoria (OR = 0.603) relative to major allele. In conclusion, DRD1 rs686 minor allele decreases the OD risk by prolonging the transition to dependence and attenuating opioid-induced pleasure in Chinese.
    PLoS ONE 08/2013; 8(8):e70805. DOI:10.1371/journal.pone.0070805 · 3.23 Impact Factor
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    ABSTRACT: To explore the ethnic differences on nutritional status of children under three years old, in the western areas of China and to indentify the affecting factors. 14 072 children under the age of three years and their mothers were recruited, using the proportion population sampling method in 45 counties in the western areas of China. Height and weight were used as the measurement on nutrition of children. Height and weight of children with Han, Uyghur, Tibetan and Zhuang ethnicities were all lower than the WHO standards and with differences on height and weight among them. There were also ethnic differences on the status of malnutrition. Prevalence rates of stunting were 14.7%, 20.3%, 26.9% and 26.5% for Han, Uyghur, Tibetan and Zhuang ethnicities, respectively. Prevalence rates of underweight were 6.1%, 10.7%, 6.8% and 15.5% among the Han, Uyghur, Tibetan and Zhuang ethnicities, respectively. The prevalence rates of wasting were 4.2%, 5.3%, 2.9%, 8.9%, and of under nutrition were 19.2%, 25.5%, 30.3% and 36.5% for the Han, the Uyghur, the Tibetan and the Zhuang ethnicities, respectively. When factors as family size, years of schooling of parents, family numbers, sex, age (months), mother's height and weight, ways of feeding and sources of family income etc. were adjusted, children with Uyghur, Tibetan, Zhuang and other ethnicities were still presented more malnutrition than the children with Han ethnicity. There were differences on malnutrition status of children under the age of three years among the studies on different ethnicities. Undernutrition was less than nutritional status, seen in children of the Han nationality than other minority ethnicites. Ethnicity seemed to be related to differences in the nutritional status of children in western China while children of the Han nationality would be better than other minorities on nutritional status if they were in same living conditionals.
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 04/2013; 34(4):346-50.
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    ABSTRACT: To evaluate the diet quality and the relative factors among rural residents in Hanzhong, Shaanxi province. A cross-sectional survey on dietary status together with a semi-quantitative food frequency questionnaire were conducted on rural residents aged from 18 to 80 in Hanzhong of Shaanxi in 2010. Diet quality was evaluated by using the Chinese Diet Balance Index (CDBI) scoring and evaluating system. Linear regression models were developed to identify factors that influencing the status of under/over intake. 2748 rural residents were investigated with the average daily intake of grains, beans, heavily salted vegetables, plant oil, nuts and salt. showed that they were higher than average level of Chinese rural residents' (P < 0.01). 80% of the residents having their daily intake of grains, oil and salt exceeded, while animal food, diary food, egg, vegetable and fruits were lower (P < 0.01) than the RNIs. However, there was under intake noticed to some extent in some areas. The average values of DBI_LBS and DBI_HBS were 22.8 and 9.8. The proportions of moderate under intake (20 < DBI_LBS ≤ 40) and moderate over intake (10 < DBI_HBS ≤ 20) were 62.6% and 48.0%. The main factors that influenced the dietary under-intake were education level, fortune index, hypertension, physical activity, and time to watch television. The main factors that affected the over-intake of diet were sex, age, number of family numbers, intensity of labor, time to sleep, smoking and drinking habits. The main diet problem among the rural residents was under-dietary-intake, with over-intake to some extents, suggesting that it was necessary to strength the specific intervention program, to improve the diet quality in the residents of Hanzhong area.
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 03/2013; 34(3):225-30.
  • Rui Zhang · Xiao-Yun Du · Jie Yu · Nan Xu · Yue-Wen Zheng · Ya-Ling Zhao · Huan Zhang · Jie Ma ·
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    ABSTRACT: We genotyped 13 single nucleotide polymorphisms (SNPs) within NRG3 to investigate the association between NRG3 and schizophrenia in 488 patients and 506 compared controls in Northwest China. No association was detected either in SNPs or in haplotypes. Our study provided no evidences that NRG3 confers risk of schizophrenia susceptibility in the Han Chinese population.
    09/2012; 205(3). DOI:10.1016/j.psychres.2012.08.017
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    ABSTRACT: To examine the relationship between cigarette smoking and body mass index (BMI) as well as waist circumference (WC) of men from 9 rural districts of Hanzhong, Shaanxi province. Cross-sectional data was analyzed from Hanzhong Health Survey on rural residents in 2010. Quantile regression mode was used to compare the results using the BMI (WC) and smoking status (degree) as the dependent variables and independent variable and confounding factors were also controlled. 1039 rmale residents of rural areas of Hanzhong city were investigated. The prevalence rates on overweight and obesity among the males were 28.0% and 5.9%, with central obesity as 35.0% and the rate of current cigarette smoking was 63.6% in the areas. from the quantile regression showed that the relationship between smoking status and BMI beyond 80 percentile in men (BMI = 24.4) which was not significantly different BMI among the heavy smokers, was much higher than those mild smokers beyond 90 percentile (BMI = 24.9). WC of the current smokers was significantly higher than those ex-smokers beyond the 95 percentile (WC = 96.7 cm). WCs of the moderate and heavy smokers had an increase along with the increase of WCs beyond the 85 percentiles (WC = 89.9 cm). The effect of smoking status and BMI (WC) were inconsistent, however, with BMI and WC increased among the subjects whose BMI or WC were at the high extreme end of the distribution. Thus, we should advise the obese subjects to quit smoking.
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 09/2012; 33(9):907-11.
  • Lin Ren · Lei-Lei Pei · Hong Yan · Qiang Li · Shao-nong Dang · Ya-ling Zhao · Xiao-ning Liu ·
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    ABSTRACT: The objective of this study was to investigate the prevalence rate of abdominal obesity and to explore the associated risk factors in rural communities from Hanzhong area, Shaanxi province, and to provide baseline data for further targeted intervention programs. A cross-sectional study was conducted among all the participants with questionnaires, interview and physical examination. Nine townships were selected in Hanzhong area, followed by one village randomly chosen from the selected township, using the stratified random sampling method. There were 3030 participants in this survey, among which 3021 samples were valid, including 1048 males and 1973 females. The overall prevalence rate of abdominal obesity was 38.9% (standardized rate as 33.4%) in rural communities of Hanzhong, and the prevalence rate on males abdominal obesity (35.0%) was significantly lower than that of females (40.9%). It was found that following factors as: being male, married, having more household wealth, frequent consumption of fried food, non-engagement of agricultural labor work, being nonsmoker or ex-smoker, spending longer time on watching-TV etc. were positively associated with the bigger odds of having abdominal obesity when using the logistic regression analysis. Meanwhile, data from this study indicated that factors as: at younger age, frequent participation in agricultural labor, under artificial feeding, with more years of education, less frequency of pregnancy etc. were negatively related to the prevalence of female abdominal obesity. The prevalence rate of abdominal obesity in Hanzhong area, Shaanxi province was significantly higher than the national average level which called for the development of related intervention programs to prevent chronic diseases associated with gender related-obesity in Hanzhong.
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 04/2012; 33(4):356-9.
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    ABSTRACT: To investigate the relationship between dietary patterns and hypertension in Hanzhong city of Shaanxi province. A cross-sectional survey on dietary pattern and hypertension together with a semi-quantitative food frequency questionnaire was conducted among rural residents aged from 18 to 80 in Hanzhong of Shaanxi province in 2010. Factor analysis by SPSS was used to identify food patterns based on the frequency of food. Logistic regression was used to analyze the relationship between dietary patterns and hypertension. 2929 rural residents were investigated with an average age as 50.0 years old and average schooling-years as 6.8. The prevalence rate of hypertension was 34.3%, with 35.4% in males and 33.7% in females. Among 29 kinds of food under investigation, only 11 kinds with the frequencies of consumption more than 1 time per week. Four main factors were derived as four dietary patterns by factor analysis and they were diversity dietary pattern, alcohol dietary pattern, beverage dietary pattern and simple dietary pattern. Among them, the balanced dietary pattern was significantly associated with hypertension. All the participants were categorized into 4 groups (Q1-Q4) according to their factor scores, quartile with Q1 as a reference. The residents who were more closer to having balance dietary pattern, were under less risk of suffering from hypertension after controlling for age, sex, BMI, education and income. Compared to Q1, the Q4 had lower risk of hypertension (OR = 0.59, 95%CI: 0.44 - 0.77) for the balanced pattern. Dietary pattern could be related to the prevalence of hypertension. A rational diet with diversity of foods should be suggested as one of the major measures for the prevention of hypertension.
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 01/2012; 33(1):37-41.