Are you Chun-Shu Pan?

Claim your profile

Publications (2)3.23 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Diffusion weighted magnetic resonance imaging (DWI) has been mostly acquired using single-shot echo-planar imaging (ss EPI) to minimize motion induced artifacts. The spatial resolution, however, is inherently limited in ss EPI especially for abdominal imaging, even with the advances in parallel imaging. A novel method of reduced Field of View ss EPI (rFOV ss EPI) has achieved high resolution DWI in human carotid artery, spinal cord with reduced blurring and higher spatial resolution than conventional ss EPI, but it has not been used to pancreas imaging. In the work, comparisons between the full FOV ss-DW EPI and rFOV ss-DW EPI in image qualities and ADC values of pancreatic tumors and normal pancreatic tissues were performed to demonstrate the feasibility of pancreatic high resolution rFOV DWI. There were no significant differences in the mean ADC values between full FOV DWI and rFOV DWI for the 17 subjects using b=600s/mm(2) (P=0.962). However, subjective scores of image quality was significantly higher at rFOV ss DWI (P=0.008 and 0.000 for b-value=0s/mm(2) and 600s/mm(2) respectively). The spatial resolution of DWI for pancreas was increased by a factor of over 2.0 (from almost 3.0mm/pixel to 1.25mm/pixel) using rFOV ss EPI technique. Reduced FOV ss EPI can provide good DW images and is promising to benefit applications for pancreatic diseases.
    Magnetic Resonance Imaging 10/2013; · 2.06 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The etiology and pathogenesis of pancreatitis remains unclear. In the presence of pancreatic inflammation, metabolite abnormalities appear before transformation of tissue structure and changes in functions occur. Detection of abnormalities in metabolite levels facilitates a greater understanding of the pathophysiological events and aids in the early diagnosis of the disease. In this study, metabolic profiles from the pancreas of Wistar rats were examined using high-resolution proton magic angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy to investigate the metabolite indicator(s) of acute necrotizing pancreatitis (ANP) and chronic pancreatitis (CP). The animals were divided into three groups: those with histologically confirmed ANP (n = 7), those with CP (n = 6) and a control group (n = 9). The processed NMR spectra were analyzed using principal component analysis (PCA) to extract characteristic metabolites of ANP and CP. Levels of leucine, isoleucine and valine were increased in the ANP group, whereas an opposite trend was observed in the CP group. Increases in phosphocholine, glycerophosphocholine and choline levels, and decreases in fatty acids, lactate, betaine and glycine levels were observed in both the ANP and CP groups. Additionally, the lipid content in the CP group was higher than that observed in the ANP group. An increase in taurine levels was observed only in the CP group. In conclusion, pancreatitis causes a disruption of the metabolism in the pancreas at a molecular level, with increased taurine levels being a potential metabolite indicator for those with CP.
    Molecular Medicine Reports 07/2012; 6(1):57-62. · 1.17 Impact Factor

Publication Stats

1 Citation
3.23 Total Impact Points

Top co-authors