ABSTRACT: INTRODUCTION: Causes of acquired thrombotic thrombocytopenic purpura (TTP) are multiple and rarely iatrogenic. CASE REPORT: A 40-year-old, HIV and hepatitis C virus co-infected woman was treated with interferon and ribavirine and developed a TTP confirmed by the presence of anti-ADAMTS 13 antibodies. The outcome was favourable when treatment was discontinued and rituximab infusion administered. CONCLUSION: The occurrence of anemia and thrombocytopenia in patients treated with interferon and ribavirine is not always related to direct toxicities of these treatments. The ADAMS 13 testing may help the clinician to diagnose iatrogenic acquired TTP.
La Revue de Médecine Interne 05/2013; · 0.61 Impact Factor
ABSTRACT: Introduction. – The features of paradoxical reactions (PR) that occurred in non-HIV infected patients
treated with antituberculous drugs are diverse. We report four new cases of such PR and review the
Patients and methods. – Were included all consecutive patients with PR that occurred in non-HIV infected patients who were treated for tuberculosis and followed-up in the department of internal medicine
and infectious diseases between January 1st, 2009 and July 31st, 2010.
Results. – Three of the patients were male. Their median age was 28.5 years. Tuberculous locations were pulmonary (two instances) and extrapulmonary (three instances). Paradoxical reactions occurred after median of 5.5 weeks after initiation of antituberculous treatment. The PR
presented as hypercalcemia (n = 1), spondylitis of the 9th thoracic vertebra (n = 1), intracerebral tuberculoma (n = 1), pericardial effusion (n = 1) and adenitis (n = 3). Lymphopenia was present in three patients. Three out of the four patients received corticosteroid. Outcome was favorable in three patients.
La Revue de Médecine Interne 03/2013; 34(4):202-208. · 0.61 Impact Factor
ABSTRACT: We report a 24-year-old woman who presented with a nephrotic syndrome as the revealing manifestation of systemic lupus erythematosus (SLE) and an associated hypogammaglobulinemia related to a common variable immunodeficiency (CVID). Outcome of SLE was favourable with intravenous immunoglobulin treatment solely. Relationships between SLE and CVID are discussed.
La Revue de Médecine Interne 05/2012; 33(6):e31-3. · 0.61 Impact Factor