T. Fukuda

Toho University, Edo, Tōkyō, Japan

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Publications (782)350.23 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Allogeneic hematopoietic SCT (allo-HSCT) is a curative treatment for aggressive adult T-cell leukemia/lymphoma (ATLL). Considering the dismal prognosis associated with conventional chemotherapies, early application of allo-HSCT might be beneficial for patients with ATLL. However, no previous study has addressed the optimal timing of allo-HSCT from related donors. Hence, to evaluate the impact of timing of allo-HSCT for patients with ATLL, we retrospectively analyzed data from patients with ATLL who received an allo-HSCT from a related donor. The median age was 52 years. Patients were grouped according to the interval from diagnosis to allo-HSCT: early transplant group, <100 days, n=72; late transplant group, ⩾100 days, n=428. The corresponding constituents of disease status were not statistically different between the two groups (P=0.11). The probability of OS in the early transplant group was significantly higher than that in the late transplant group (4-year OS, 49.3% vs 31.2%). Multivariate analysis revealed that late allo-HSCT was an unfavorable prognostic factor for OS (hazard ratio, 1.46; 95% confidence interval (CI), 1.01-2.11; P=0.04). Despite the limitations of a retrospective study, it might be acceptable to consider early application of allo-HSCT for ATLL.Bone Marrow Transplantation advance online publication, 2 November 2015; doi:10.1038/bmt.2015.265.
    Bone marrow transplantation 11/2015; DOI:10.1038/bmt.2015.265 · 3.57 Impact Factor

  • Value in Health 11/2015; 18(7):A397. DOI:10.1016/j.jval.2015.09.903 · 3.28 Impact Factor
  • S Saito · T Shiroiwa · T Fukuda · K Shimozuma ·

    Value in Health 11/2015; 18(7):A532. DOI:10.1016/j.jval.2015.09.1659 · 3.28 Impact Factor

  • Value in Health 11/2015; 18(7):A467. DOI:10.1016/j.jval.2015.09.1228 · 3.28 Impact Factor
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    ABSTRACT: We conducted a comprehensive analysis of 28 recurrently mutated genes in acute myeloid leukemia (AML) in 271 patients with de novo AML. Co-mutations were frequently detected in the intermediate cytogenetic risk group, at an average of 2.76 co-mutations per patient. When assessing the prognostic impact of these co-mutations in the intermediate cytogenetic risk group, overall survival (OS) was found to be significantly shorter (P=0.0006) and cumulative incidence of relapse (CIR) significantly higher (P=0.0052) in patients with complex molecular genetic abnormalities (CMGAs) involving three or more mutations. This trend was marked even among patients aged ⩽65 years who were also FLT3-ITD-negative (OS: P=0.0010; CIR: P=0.1800). Moreover, the multivariate analysis revealed that CMGA positivity was an independent prognostic factor associated with OS (P=0.0007). In stratification based on FLT3-ITD and CEBPA status and 'simplified analysis of co-mutations' using seven genes which featured frequently in CMGAs, CMGA positivity retained its prognostic value in transplantation-aged patients of the intermediate cytogenetic risk group (OS: P=0.0002. CIR: P<0.0001). In conclusion, CMGAs in AML were found to be strong independent adverse prognostic factors and simplified co-mutation analysis to have clinical usefulness and applicability.Leukemia accepted article preview online, 21 October 2015. doi:10.1038/leu.2015.288.
    Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 10/2015; DOI:10.1038/leu.2015.288 · 10.43 Impact Factor
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    ABSTRACT: Hypernuclear production cross sections have been deduced for the first time with induced reaction of heavy ion beam on fixed target and by means of the invariant mass method by the HypHI Collaboration exploiting the reaction of 6Li + 12C at or . A production cross section of for 3ΛH and of for 4ΛH respectively in the projectile rapidity region was inferred as well as the total production cross section of the Λ hyperon was measured and found to be equal to . A global fit based on a Bayesian approach was performed in order to include and propagate statistical and systematic uncertainties. Production ratios of 3ΛH/4ΛH, 3ΛH/Λ and 4ΛH/Λ were included in the inference procedure. The strangeness population factors S3 and S4 of 3ΛH and 4ΛH respectively were extracted. In addition, the multiplicities of the Λ hyperon, 3ΛH, and 4ΛH together with the rapidity and transversal momentum density distributions of the observed hypernuclei were extracted and reported.
    Physics Letters B 07/2015; 747. DOI:10.1016/j.physletb.2015.05.059 · 6.13 Impact Factor
  • T. Kobayashi · K. Sekiyama · T. Aoyama · Y. Hasegawa · T. Fukuda ·
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    ABSTRACT: Walking capability composed of stability and efficiency is one of the most important issues in the field of humanoid robots. An effective swing of the arms is expected to enhance the walking capability under the constraints from the limited body. We propose an arm-swing method to enhance the stability and efficiency by selecting optimal arm-swing strategy depending on the walking conditions. In this research, we select the optimal strategy between the support of the center of gravity (COG) tracking for stability and the walk without arm-swing for efficiency. To support the COG tracking, we employ a predictive control. States are defined as an inverted pendulum model and inputs are given as an inertial force of arm-swing. Input and output weights in the predictive control are adjustable by a support weight introduced in this paper. Selection of the optimal support weight by a selection algorithm for locomotion (Su-SAL) switches the two strategies by adjusting the ratio of input and output (I/O) weights. Su-SAL maximizes the efficiency while keeping the stability in comparison with the case of the constant support weight.
    Proceedings - IEEE International Conference on Robotics and Automation 06/2015; 2015:5698-5703. DOI:10.1109/ICRA.2015.7139997
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    ABSTRACT: When discussing treatment options for patients with acute leukemia, it is important to acknowledge the impact of allogeneic hematopoietic cell transplantation (allo-HCT) or chemotherapy on quality of life (QOL). We performed a cross-sectional questionnaire study that administered SF-36, FACT-Leukemia and EuroQOL5D to 524 acute leukemia survivors, to compare patient-reported QOL between chemotherapy and allo-HCT, and to elucidate predictors of QOL. Patients who received chemotherapy alone had a better physical QOL than those who received allo-HCT. On the other hand, the allo-HCT group reported a better mental QOL. In the comparison of QOL in the allo-HCT patients according to the presence of GVHD at survey, patients who had GVHD symptoms experienced statistically and clinically significantly worse QOL than those who did not. In the allo-HCT patients without GVHD, the physical QOL was comparable to that in the chemotherapy patients, and they experienced significantly better mental and general QOL than the chemotherapy patients. GVHD and immunosuppressive drugs at survey were strongly associated with worse QOL after allo-HCT. In the chemotherapy group, a shorter time between treatment completion and survey was significantly associated with worse QOL. Further evaluation of QOL by a longitudinal assessment with quantitative and qualitative analyses are warranted.Bone Marrow Transplantation advance online publication, 15 June 2015; doi:10.1038/bmt.2015.137.
    Bone marrow transplantation 06/2015; 50(9). DOI:10.1038/bmt.2015.137 · 3.57 Impact Factor
  • M Ogata · T Fukuda · T Teshima ·
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    ABSTRACT: Human herpesvirus-6 (HHV-6) encephalitis following allogeneic hematopoietic cell transplantation is a serious and often fatal complication accompanying reactivation of HHV-6B. Incidence varies among studies, but is reportedly 0-11.6% after bone marrow or PBSC transplantation and 4.9-21.4% after umbilical cord blood transplantation, typically around 2-6 weeks post transplant. Symptoms are characterized by memory loss, loss of consciousness and seizures. Magnetic resonance imaging (MRI) typically shows bilateral signal abnormalities in the limbic system. This complication is considered to represent acute encephalitis caused by direct virally induced damage to the central nervous system, but our understanding of the etiologies and pathogenesis is still limited. The mortality rate attributable to this pathology remains high, and survivors are often left with serious sequelae such as impaired memory and epilepsy. Despite the poor prognosis, no validated treatments or preventative measures have been established. Establishment of preventative strategies represents an important challenge. This article reviews the current knowledge of the clinical features, incidence, pathogenesis and treatment of HHV-6 encephalitis, and discusses issues needing clarification in the future to overcome this serious complication.Bone Marrow Transplantation advance online publication, 27 April 2015; doi:10.1038/bmt.2015.76.
    Bone marrow transplantation 04/2015; 50(8). DOI:10.1038/bmt.2015.76 · 3.57 Impact Factor
  • S. Mikami · T. Fukuda · A. Igarashi · S. Suzuki ·
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    ABSTRACT: A legged robot is one of the ideal mechanisms for moving around muddy, irregular, and fragile surfaces. However, a legged robot will easily be unable to move if its body is turned over. Some robots have special mechanisms for recovery. But having extra mechanisms may increase possibilities of malfunction. Our approach is to make a robot that has legs around its body so that it never turns over. Also our idea is to drive these legs synchronously by a set of gears and links so that it performs the same gait to the same moving direction. We found that this is possible for any prismatic bodies that have side surfaces of a multiple of four. In this paper we demonstrate this by some examples of four side surfaces configurations.
  • T. Kobayashi · K. Sekiyama · T. Aoyama · Y. Hasegawa · T. Fukuda ·
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    ABSTRACT: Humanoid robots are required to improve its walking ability (stability and efficiency) in order to adapt to various environments. Extension of the embodiment by a cane is effective as well as human like elderly. In this paper, we propose a scheme that enables the robot to perform cane-supported walking and select the optimal cane usage based on its condition so as to maximize the performance of cane support. For cane-supported walking, we propose cyclic and leg-like usages, which correspond to two-point and three-point gaits. Our strategy for selecting the optimal cane usages, which have respective utilities, utilizes falling factors in Selection Algorithm for Locomotion (Us-SAL). We express affinities between the cane usages and the falling factors as Q-values, which are learned by Q-learning, and select the optimal usage based on the Q-values. Us-SAL was validated by an experiment; the robot selected the optimal usage for its condition, and walked efficiently without falling.
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    ABSTRACT: This paper presents a local microinjection system using hydro-gel beads based on micromanipulation near nerve axon of Caenorhabditis elegans (C. elegans), which is one of the important model organism for disease analysis and nerve analysis. The hydro-gel beads were prepared using Polyethylene Glycol Diacrylate (PEG-DA) to encapsulate biomaterials. The tip of micro-pipette tool was used to attach the hydro-gel beads by a negative pressure with a syringe. The local-nano-injection technique was demonstrated to inject fluorescent materials into C. elegans using the micro-pipette tool by a piezo actuator. The microinjection was evaluated in a three dimensional space by a confocal microscope. The proposed microinjection method is considered to be important as future micro-nano surgery system for life innovation using model organism.
  • K Takano · S Fuji · N Uchida · H Ogawa · K Ohashi · T Eto · H Sakamaki · Y Morishima · K Kato · R Suzuki · T Fukuda ·
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    ABSTRACT: Diabetes mellitus (DM) is a factor in the hematopoietic cell transplantation-comorbidity index. However, the impact of pre-transplant DM on morbidity and cause-specific non-relapse mortality (NRM) remains unclear. We performed a retrospective study with registry data that included a total of 7626 patients who underwent their first allogeneic hematopoietic SCT (HSCT) between 2007 and 2010. The median age was 44 years (range 0-88). Compared with patients without pre-transplant DM (non-DM group, n=7248), patients with pre-transplant DM (DM group, n=378) were older and were more likely to have high-risk disease, a reduced-intensity conditioning regimen and GVHD prophylaxis using tacrolimus. Multivariate analyses showed that pre-transplant DM was associated with increased risks of NRM (hazard ratio (HR)1.46, 95% confidence interval (CI) 1.21-1.76, P<0.01) and infection-related NRM (HR 2.08, 95% CI 1.58-2.73, P<0.01). The presence of pre-transplant DM was associated with an increased risk of overall mortality in a multivariate analysis (HR 1.55, 95% CI 1.35-1.78, P<0.01). In conclusion, pre-transplant DM was a risk factor for NRM, particularly infection-related mortality, after allogeneic HSCT. To improve the clinical outcome in patients with DM, the benefits of strict infection control and appropriate glycemic control should be explored in future trials.Bone Marrow Transplantation advance online publication, 26 January 2015; doi:10.1038/bmt.2014.315.
    Bone Marrow Transplantation 01/2015; 50(4). DOI:10.1038/bmt.2014.315 · 3.57 Impact Factor
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    ABSTRACT: The impact of the conditioning intensity and TBI on acute GVHD (aGVHD) is still a matter of debate. We analyzed 6848 adult recipients who received allogeneic hematopoietic cell transplants (HCT) between 2006 and 2011 in Japan. The subjects were divided into groups who had received myeloablative conditioning (MAC) or reduced-intensity conditioning (RIC), either with or without TBI. There was a significant difference in the incidence of aGVHD 2-4 among the different conditioning types: 39% in TBI-MAC, 35% in TBI-RIC and 32% in both no-TBI MAC and no-TBI-RIC (P<0.001). In a multivariate analysis, TBI-MAC, but not no-TBI MAC, was significantly associated with an increased risk of aGVHD 2-4 (hazard ratio (HR) 1.33, P<0.01), whereas TBI-RIC was associated with an increased risk of GVHD 3-4 (HR 1.36, P=0.048). TBI-MAC and TBI-RIC were significantly associated with skin and gastrointestinal aGVHD. Subgroup analyses demonstrated that not only TBI-MAC, but also TBI-RIC, was significantly associated with aGVHD 2-4 in older patients. Furthermore, high-dose TBI only had an adverse impact on aGVHD 2-4 in HLA-matched HCT. Impacts of intensity and TBI on aGVHD differ by patient backgrounds, and this difference should be considered to establish a risk-adapted strategy for the prevention of aGVHD.Bone Marrow Transplantation advance online publication, 22 December 2014; doi:10.1038/bmt.2014.293.
    Bone Marrow Transplantation 12/2014; 50(4). DOI:10.1038/bmt.2014.293 · 3.57 Impact Factor
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    ABSTRACT: We previously developed an automatic track scanning system which enables the detection of large-angle nuclear fragments in the nuclear emulsion films of the OPERA experiment. As a next step, we have investigated this system's track recognition capability for large-angle minimum ionizing particles $(1.0 \leq |tan \theta| \leq 3.5)$. This paper shows that, for such tracks, the system has a detection efficiency of 95$\%$ or higher and reports the achieved angular accuracy of the automatically recognized tracks. This technology is of general purpose and will likely contribute not only to various analyses in the OPERA experiment, but also to future experiments, e.g. on low-energy neutrino and hadron interactions, or to future research on cosmic rays using nuclear emulsions carried by balloons.
    Journal of Instrumentation 12/2014; 9(12). DOI:10.1088/1748-0221/9/12/P12017 · 1.40 Impact Factor
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    ABSTRACT: Risk of relapse during the unrelated donor coordination period biases comparisons between allogeneic hematopoietic stem cell transplantation from an HLA 8 of 8 allele-matched unrelated donor (8/8 MUD) and that from a related donor with an HLA-1 antigen mismatch in the graft-versus-host (GVH) direction (RD/1AGMM-GVH). To reduce this bias, we performed a decision analysis focusing on acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) in first complete remission (CR1). The primary outcome measure was 5-year survival probability with or without quality-of-life (QOL) adjustment. A baseline analysis showed that the decision to perform MUD transplantation was superior to that to perform RD/1AGMM-GVH transplantation for patients with AML or ALL. However, in the ALL cohort, the direction of superiority was reversed when the interval between CR1 and 8/8 MUD transplantation was >5.5 months (without QOL adjustment) or >6 months (after QOL adjustment) or when overall survival of RD/1AGMM-GVH transplantation improved by 1.3% without QOL adjustment and 2.1% after QOL adjustment. In conclusion, 8/8 MUD should be prioritized in transplantation for AML and ALL in CR1. However, the MUD coordination period and improvements in RD/1AGMM-GVH transplantation might change the donor selection priority in transplantation for ALL in CR1.Blood Cancer Journal (2014) 4, e263; doi:10.1038/bcj.2014.85.
    Blood Cancer Journal 12/2014; 4(12):e263. DOI:10.1038/bcj.2014.85 · 3.47 Impact Factor
  • S. Noto · K. Shimozuma · S. Saito · T. Shiroiwa · T. Fukuda · K. Moriwaki · R. Izumi ·

    Value in Health 11/2014; 17(7):A514. DOI:10.1016/j.jval.2014.08.1585 · 3.28 Impact Factor
  • H. Fukuda · S. Ikeda · T. Shiroiwa · A. Igarashi · T. Fukuda ·

    Value in Health 11/2014; 17(7):A341. DOI:10.1016/j.jval.2014.08.678 · 3.28 Impact Factor
  • T Shiroiwa · K Shimozuma · T Fukuda ·

    Value in Health 11/2014; 17(7):A735. DOI:10.1016/j.jval.2014.08.104 · 3.28 Impact Factor
  • Source
    S Fuji · T Mori · N Khattry · J Cheng · Y R Do · K Yakushijin · S Kohashi · T Fukuda · S-W Kim ·
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    ABSTRACT: Patients after allogeneic hematopoietic SCT (HSCT) are at risk of malnutrition. To assess the impact of malnutrition after allogeneic HSCT on transplant outcomes, we conducted a retrospective study. Adult patients who received allogeneic HSCT from 2000 to 2009 for standard-risk leukemia and achieved disease-free survival up to 3 months after allogeneic HSCT were included. From participating centers, 145 patients were enrolled. Median age was 46 years (19-68). Patients were classified based on weight loss during 3 months after allogeneic HSCT as follows: normal group (weight loss <5%, n=53), mild malnutrition group (5%⩽weight loss<10%, n=47), severe malnutrition group (10% ⩽weight loss, n=45). The cumulative incidences of 2-year nonrelapse mortality (NRM) were 3.8% in the normal group, 8.5% in the mild malnutrition group and 27.3% in the severe malnutrition group. The probabilities of a 2-year OS were 73.2% in the normal group, 74.5% in the mild malnutrition group and 55.3% in the severe malnutrition group. In multivariate analysis, severe malnutrition was associated with an increased risk of NRM and a worse OS. In conclusion, weight loss ⩾10% was associated with a worse clinical outcome. Prospective studies that identify patients at risk of malnutrition and intervention by a nutritional support team are warranted.Bone Marrow Transplantation advance online publication, 6 October 2014; doi:10.1038/bmt.2014.228.
    Bone Marrow Transplantation 10/2014; 50(1). DOI:10.1038/bmt.2014.228 · 3.57 Impact Factor

Publication Stats

7k Citations
350.23 Total Impact Points


  • 2012-2014
    • Toho University
      Edo, Tōkyō, Japan
  • 2013
    • Meijo University
      Nagoya, Aichi, Japan
  • 2002-2013
    • Osaka Electro-Communication University
      Neyagawa, Ōsaka, Japan
  • 1996-2013
    • Tohoku University
      • • Graduate School of Agricultural Science
      • • Graduate School of Dentistry
      • • Department of Bioengineering and Robotics
      Sendai, Kagoshima-ken, Japan
    • National Technical University of Athens
      Athínai, Attica, Greece
    • Fisheries Research Agency
      Yokohama, Kanagawa, Japan
  • 1989-2013
    • Nagoya University
      • • Department of Micro-Nano Systems Engineering
      • • Department of Mechanical Science and Engineering
      Nagoya, Aichi, Japan
  • 2009
    • Seoul National University
      • Department of Physics and Astronomy
      Seoul, Seoul, South Korea
  • 2008
    • Huazhong University of Science and Technology
      • Department of Control Science and Engineering
      Wu-han-shih, Hubei, China
    • University of Tsukuba
      • Intelligent System Technologies
      Tsukuba, Ibaraki, Japan
  • 2006
    • Tanta University
      • Department of Mechanical Power Engineering
      Tanda, Muhafazat al Gharbiyah, Egypt
  • 2001-2005
    • High Energy Accelerator Research Organization
      • Institute of Particle and Nuclear Studies
      Tsukuba, Ibaraki, Japan
    • Kyoto University
      • Department of Physics II
      Kyoto, Kyoto-fu, Japan
  • 2003-2004
    • Oakland University
      • Department of Computer Science and Engineering
      Rochester, Michigan, United States
    • Samsung Advanced Institute of Technology
      Usan-ri, Gyeonggi Province, South Korea
  • 1999-2004
    • Saga University
      • Department of Advanced Systems Control Engineering
      Сага Япония, Saga, Japan
    • National Cancer Center, Japan
      Edo, Tōkyō, Japan
  • 1998-2004
    • Kagawa University
      • Department of Intelligent Mechanical Systems Engineering
      Takamatsu-shi, Kagawa-ken, Japan
    • Advance Institute of Science and Technology
      Dehra, Uttarakhand, India
  • 2001-2002
    • Fukui University
      Hukui, Fukui, Japan
  • 2000-2001
    • Michigan State University
      • Department of Electrical and Computer Engineering
      East Lansing, MI, United States
    • Xi'an Technological University
      Ch’ang-an, Shaanxi, China
    • Sankyo Kasei Co., Ltd.
      Ōsaka, Ōsaka, Japan
    • Shizuoka University
      • Department of Mechanical Engineering
      Shizuoka-shi, Shizuoka-ken, Japan
  • 1999-2000
    • Tokyo Denki University
      • Division of Science
      Edo, Tōkyō, Japan
  • 1997-2000
    • Osaka Institute of Technology
      • Department of Mechanical Engineering
      Ōsaka, Ōsaka, Japan
  • 1997-1999
    • Shinryo Corporation
      Edo, Tōkyō, Japan
  • 1986-1999
    • Tokyo University of Science
      • • Department of Management Science
      • • Department of Mechanical Engineering (School of Engineering)
      Edo, Tōkyō, Japan
  • 1996-1997
    • Mie University
      • Department of Mechanical Engineering
      Tu, Mie, Japan
  • 1988-1997
    • The University of Tokyo
      • • Department of Physics
      • • Department of Mechanical Engineering
      Edo, Tōkyō, Japan
  • 1995
    • The University of Electro-Communications
      Edo, Tōkyō, Japan
    • Kisarazu National College of Technology
      Kizarazu, Chiba, Japan
    • Omron Corporation
      Kioto, Kyōto, Japan
    • Sugiyama Jogakuen University
      Nagoya, Aichi, Japan
    • Universität Stuttgart
      • Institute of Theoretical Physics
      Stuttgart, Baden-Wuerttemberg, Germany
  • 1994
    • Kyushu University
      Hukuoka, Fukuoka, Japan
  • 1993
    • Mohawk Innovative Technology, Inc.
      Albany, New York, United States
  • 1992-1993
    • Kinjo Gakuin University
      Nagoya, Aichi, Japan
  • 1987-1990
    • Osaka University
      • Department of Physics
      Suika, Ōsaka, Japan