Y Qian

Publications (2)4.42 Total impact

• Article: Investigation of intracranial aneurysm hemodynamics following flow diverter stent treatment.

  Y Zhang, W Chong, Y Qian
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  ABSTRACT: Flow diverters (FDs) are high density meshed stents designed to reduce blood flow into intra-cranial aneurysms. Though the FD is one of many intracranial aneurysm (IA) treatments, FD implantation may also result in the growth and rupture of residual aneurysms. The purpose of this research is to investigate the effect of FD implantation on IA hemodynamics. Computational fluid dynamics (CFD) was conducted to analyze dynamic and resistance forces after FD deployment. Simulation results for the successful case (patient A) showed that FD flow resistance force was higher than dynamic force. This indicated that the FD provided sufficient resistance to reduce flow into the aneurysm. As a result, flow velocity magnitude at the aneurysm neck was reduced by 95%. On the other hand, the flow velocity magnitude at the aneurysm neck was reduced by about 50% for the unsuccessful case (patient B). The reason was that the flow resistance force at the aneurysm neck section was calculated to be lower than the flow driving force. In order to completely occlude the aneurysm, a higher resistance FD stent is to be required to suppress the dynamic forces. Patient-specific hemodynamic simulations offer means of quantitative estimation FD treatment outcomes.
  Medical Engineering & Physics 08/2012; · 1.62 Impact Factor
• Article: Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population.

  Y Wang, Y Zhang, J Zhang, X Tang, Y Qian, P Gao, D Zhu
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  ABSTRACT: Alcohol consumption is an important environmental factor in the development of essential hypertension (EH) and cardiovascular disease. Several epidemiological studies have investigated the association between hypertension and acetaldehyde dehydrogenase 2 (ALDH2) genotype, although the results are inconsistent. The aim of the present study was to evaluate the possible effect of drinking behavior on the ALDH2-EH relationship in a Chinese Han population. A total of 1098 unrelated individuals with EH and 1021 controls of Chinese Han ethnicity were included. We evaluated the effect of three tag single-nucleotide polymorphisms on blood pressure (BP) and serum lipid level by blood chemical assays. The major findings were that rs671 guanine/adenine genotype (odds ratio (OR)=0.45, 95% confidence interval (CI): 0.28-0.74) and A allele (OR=0.55, 95% CI: 0.36-0.85) were associated with a decreased risk of EH in drinkers. In addition, the rs671 genotype influenced BP, triglyceride (TG) level and high-density lipoprotein cholesterol (HDL-C) level in the same drinking-dependent pattern. Drinkers who carried the A allele displayed lower systolic BP (β=-0.16, P=0.001) and TG level (β=-0.14, P=0.004) and higher HDL-C level (β=0.11, P=0.019), but this association was not observed in nondrinkers. In summary, we present evidence for the association of rs671 in the ALDH2 gene with susceptibility to EH, increase in BP and disturbance of serum lipid profiles in drinkers, but not in nondrinkers. Further functional research is warranted to elucidate the role of rs671 in the variation of BP and lipid levels in EH.Journal of Human Hypertension advance online publication, 3 May 2012; doi:10.1038/jhh.2012.15.
  Journal of human hypertension 05/2012; · 2.80 Impact Factor