Kwang Hyun Kim

Chonnam National University, Gwangju, Gwangju, South Korea

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Publications (18)25.72 Total impact

  • Jong‐Uk Jeong · Minyu Song · Younghoon Kim · Kwang‐Hyun Kim · Jaheon Kang · Sejong Oh ·
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    ABSTRACT: The antimutagenic activities of sixteen strains of Lactobacillus were evaluated using three mutagens (4-nitroquinoline-N'-oxide, 4-NQO; N-methyl-N'nitro-N-nitrosoguanidine, MNNG; and 2-amino-3-methylimidazole quinoline, IQ). Among the tested Lactobacillus strains, Lactobacillus plantarum strain JNU 2116 had the highest antimutagenic activity in the presence of 4-NQO, MNNG and IQ (21.5, 25.8 and 34.54% inhibition, respectively). The molecular weight of the antimutagenic peptide was estimated at approximately 762 Da, and the N-terminal amino acid residue sequence of the purified peptide was identified as NH2- XLEXKKAEXITTXX. This peptide may be able to counteract the activity of carcinogens and other toxins if it is added to functional dairy products.
    International Journal of Dairy Technology 04/2015; 68(4). DOI:10.1111/1471-0307.12216 · 0.94 Impact Factor
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    ABSTRACT: Effects of citrus pulp, fish by-product and Bacillus subtilis fermentation biomass on growth performance, nutrient digestibility, and fecal microflora of weanling pigs Abstract An experiment was conducted to investigate the effects of dietary supplementation with citrus pulp, fish by-product, and Bacillus subtilis fermentation biomass on the growth performance, apparent total tract digestibility (ATTD) of nutrients, and fecal microflora of weanling pigs. A total of 180 weaned piglets (Landrace × Yorkshire × Duroc) were randomly allotted to three treatments on the basis of body weight (BW). There were six replicate pens in each treatment with 10 piglets per pen. Dietary treatments were corn-soybean meal-based basal diet supplemented with 0 (control), 2.5, and 5.0% citrus pulp, fish by-product, and B. subtilis fermentation biomass. The isocaloric and isoproteineous experimental diets were fed in mash form in two phases (d 0 ~ 14, phase I and d 15 ~ 28, phase II). Dietary treatments had significant linear effects on gain to feed ratio (G:F) in all periods, whereas significant linear effects on ATTD of dry matter (DM), gross energy (GE), and ash were only observed in phase I. Piglets fed diet supplemented with 5.0% citrus pulp, fish by-product, and B. subtilis fermentation biomass showed greater (p < 0.05) G:F (phase I, phase II, and overall) as well as ATTD of DM, GE, and ash (phase I) than pigs fed control diet. Dietary treatments also had significant linear effects on total anaerobic bacteria populations by d 14 and 28. In addition, piglets fed diet supplemented with 5.0% citrus pulp, fish by-product and B. subtilis fermentation biomass showed greater (p < 0.05) fecal total anaerobic bacteria populations (d 14 and 28) than pigs fed control diet. Dietary treatments had no significant effects (linear or quadratic) on average daily gain (ADG), average dial feed intake (ADFI; phase I, phase II, and overall), or fecal populations of Bifidobacterium spp., Clostridium spp., and coliforms (d 14 and 28). These results indicate that dietary supplementation with 5.0% citrus pulp, fish by-product, and B. subtilis fermentation biomass has the potential to improve the feed efficiency, nutrient digestibility, and fecal microflora of weanling pigs.
    Journal of Imaging Science and Technology 07/2014; 56(1). DOI:10.1186/2055-0391-56-10 · 0.35 Impact Factor

  • Journal of Animal Research 01/2014; 4(2):155. DOI:10.5958/2277-940X.2014.00001.1
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    ABSTRACT: A new self-assembly method for the fabrication of periodic structures using monodispersed polystyrene nanoparticles matrix was developed. The self-assembly could be formed into polystyrene nanoparticles matrix constructed by the face centered cubic (FCC) structure and hexagonally close-packed (HCP) monolayer. The polystyrene nanoparticles have been prepared by emulsion polymerization. Several aspects were investigated by using different techniques: Particle sizer, TEM and DSC etc. In this study, the feasibility of synthesizing nanoparticles of 550 nm polystyrene with a perfect spherical shape and a narrow size distribution was demonstrated. Subsequently, an investigation of the self-assembly of polystyrene nanospheres to built up an opal structure was performed. This arrangement was achieved by gravitational sedimentation under vacuum. The face centered cubic structure was identified by using SEM, thus that the different facet type {100}, {110} and {111} were composed. The self-assembly of monodispersed polystyrene nanoparticles in 2D structure was fabricated in the structure of hexagonally close-packed monolayer.
    Journal of Nanoscience and Nanotechnology 09/2013; 13(9):6300-6. DOI:10.1166/jnn.2013.7714 · 1.56 Impact Factor
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    ABSTRACT: An experiment was conducted to determine the effects of origins of soybean meal (SBM) on growth performance, nutrients and energy retention and fecal microflora in broilers. The SBM originating from Korea, Brazil and India were used. A total of 480 broiler chicks (average initial BW, 41.8 g) were randomly allotted to 6 treatments. Each treatment had 4 replicate pens with 20 chicks per pen. Birds were fed diets containing SBM originated from Korea (domestic SBM), Brazil or India (imported SBM) and the diets were based on the total amino acid (TAA) or true digestible amino acid (TDAA). Experimental diets were fed in two phases, starter (d 0~21) and finisher (d 22~35). The overall weight gain, feed intake and FCR were better (P
    06/2013; 40(2). DOI:10.5536/KJPS.2013.40.2.129
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    ABSTRACT: Background: The increase in drug-resistant bacteria and the ban on antibiotic growth promoters worldwide make the search for novel means of preventing bacterial infection and promoting growth performance imperative. In this sense, antimicrobial peptides are thought to be ideal candidates owing to their antimicrobial properties, broad spectrum of activity and low propensity for development of bacterial resistance. The aim of the present study was to investigate the effect of dietary supplementation with antimicrobial peptide-P5 (AMP-P5) on weanling pig nutrition. Results: A total of 240 weanling pigs were allotted to four treatments on the basis of initial body weight. There were four replicates in each treatment, with 15 pigs per replicate. Dietary treatments were negative control (NC, basal diet without antimicrobial), positive control (PC, basal diet + 1.5 g kg(-1) apramycin), basal diet with 40 mg kg(-1) AMP-P5 (P5-40) and basal diet with 60 mg kg(-1) AMP-P5 (P5-60). Pigs fed the PC or P5-60 diet showed improved (P < 0.05) overall growth performance, apparent total tract digestibility of dry matter, crude protein and gross energy and reduced (P < 0.05) faecal and intestinal coliforms compared with pigs fed the NC diet. Conclusion: The results obtained in this study indicate that dietary supplementation with 60 mg kg(-1) AMP-P5 has the potential to improve the growth performance and apparent total tract digestibility of nutrients and reduce coliforms in weanling pigs.
    Journal of the Science of Food and Agriculture 02/2013; 93(3). DOI:10.1002/jsfa.5840 · 1.71 Impact Factor
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    ABSTRACT: Objective: To present our long-term follow-up data to investigate whether cigarette smoking is associated with the prognosis of bladder cancer after radical cystectomy. Despite the close link between cigarette smoking and the development of bladder cancer, little is known about the influence of cigarette smoking on the bladder cancer prognosis after radical cystectomy. Materials and methods: The cigarette smoking status of 602 patients who had undergone radical cystectomy for bladder cancer was determined using questionnaires completed before surgery. The effect of cigarette smoking on recurrence-free survival, cancer-specific survival, and overall survival was determined. Results: Of the 340 patients with a smoking history, 159 were current smokers. The smokers were younger (P = .001) and more likely to be male (P = .001) than were the nonsmokers. The 5-year recurrence-free survival rate of the smokers and nonsmokers was 62.1% and 56.8% (P = .182), the 5-year cancer-specific survival rate was 67.3%, 63.9% (P = .436), and the 5-year overall survival rate was 63.0% and 58.8% (P = .309), respectively. Multivariate analysis revealed that smoking was not an independent predictor of recurrence-free survival or cancer-specific survival. After adjusting for other prognostic variables, cigarette smoking status (non-, ex-, or current smoker), cumulative exposure, and years from smoking cessation were not associated with cancer-specific survival (P = .378, P = .827, and P = .876, respectively). Conclusion: The results of the present study found no association between cigarette smoking and the prognosis of bladder cancer after radical cystectomy.
    Urology 10/2012; 80(6). DOI:10.1016/j.urology.2012.08.026 · 2.19 Impact Factor
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    ABSTRACT: Study Type – Prognosis (case series) Level of Evidence 4 What's known on the subject? and What does the study add? In patients with pRCC, the presence of venous tumour thrombus is known to be a predictor of poorer outcomes. However, a paucity of data is available regarding the prognostic significance of histology in patients with RCC and IVC thrombus. In our series, we found that patients with type II pRCC had significantly poorer outcomes when compared to those with cRCC. Although the lack of effective treatment for patients with metastatic pRCC may have contributed to these adverse outcomes, type II papillary histology was independent predictor not only of CSS but also of RFS.
    BJU International 09/2012; 110(11B). DOI:10.1111/j.1464-410X.2012.11498.x · 3.53 Impact Factor
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    ABSTRACT: OBJECTIVES: To evaluate the risk factors and prognosis of muscle-invasive bladder cancer (MIBC) developing after nephroureterectomy for upper urinary tract urothelial cell carcinoma (UUT-UC). MATERIALS AND METHODS: We reviewed the medical records of 422 patients who underwent nephroureterectomy for UUT-UC between 1990 and 2010, and identified 173 (40.9%) with intravesical recurrence and 28 (6.6%) with MIBC. We evaluated the clinicopathologic features, risk factors, and cancer-specific survival (CSS) using the Kaplan-Meier method and the Cox proportional hazards regression models. RESULTS: The median intervals from nephroureterectomy to intravesical recurrence and the development of MIBC were 8 and 17 months, respectively. On multivariate analysis, the pathologic stage (≥pT3 vs. Ta/T1, HR 5.03, P = 0.001) and ureteral tumor location (HR 2.79, P = 0.011) were independent risk factors for the development of MIBC, whereas a history of previous or concomitant bladder tumor was the only significant risk factor for intravesical recurrence. The probability of developing MIBC 5 years after nephroureterectomy was 12.6% in patients with 1 risk factor and 20.6% in patients with both risk factors. Patients with MIBC had significantly worse CSS than those without MIBC (P = 0.004), whereas CSS rates were similar in patients with and without intravesical recurrence (P = 0.593). However, stratification analysis for matching pathology revealed that CSS rates were not significantly different in patients with pT2 or higher stage of UUT-UC. CONCLUSIONS: Approximately 5% of the patients developed MIBC after nephroureterectomy with a median interval of 17 months. Patients with advanced pathologic stage (≥pT3) and a ureteral tumor location are at increased risk of developing MIBC after nephroureterectomy.
    Urologic Oncology 05/2012; 31(8). DOI:10.1016/j.urolonc.2012.04.014 · 2.77 Impact Factor
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    ABSTRACT: To evaluate the impact of surgical waiting time (SWT) on outcomes of patients who underwent radical nephrectomy for stage II or higher renal cell carcinoma (RCC). Of the 1,732 patients who underwent surgery for RCC between 1989 and 2007, medical records of 319 with clinical stage II or higher RCC without distant metastases were retrospectively reviewed. Ten patients with SWT greater than 3 months were excluded from analysis, and we compared pathological upstaging and survival rates between patients with SWT <1 month (234/319, 73.3 %) and 1-3 months (75/319, 23.5 %). Clinicopathological characteristics between two groups were not different except the presence of symptom. The pathological upstaging was higher in patients with SWT of 1-3 months but statistically not significant. SWT of 1-3 months was not an independent predictor of pathological upstaging, recurrence-free survival (RFS; p = 0.896), or cancer-specific survival (CSS; p = 0.737). On subgroup analysis by TNM stage (cT2NxcM0 and cT3-4NxcM0), SWT of 1-3 months was not an independent predictor of pathological upstaging and was not associated with RFS or CSS. SWT, treated as a continuous variable, was also not an independent predictor of outcome in any subgroup. Similar results were found in symptomatic patients. The outcomes of patients with prolonged SWT did not differ from those of most patients who underwent nephrectomy within 1 month. In patients with stage II or higher RCC who underwent nephrectomy within 3 months after diagnosis, prolonged SWT was not an independent predictor of pathological upstaging, RFS, or CSS.
    Journal of Cancer Research and Clinical Oncology 05/2012; 138(9):1561-7. DOI:10.1007/s00432-012-1230-2 · 3.08 Impact Factor
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    Jea Hyung Cho · Kwang Hyun Kim · Young Hyun Chung ·
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    ABSTRACT: This study is focused on the structure and other possible factors related to scintillators used in the Fast Neutron and Gamma-ray Radiography (FNGR) system to increase its sensitivity. The CsI(Tl) crystal scintillator (Co-60 gamma-ray detection) and the BC430 plastic scintillator (14 MeV fast neutron detection) were analyzed with the Monte Carlo simulation (MCNPX and DETEC97 codes). Each scintillator was investigated with regard to the optimum thickness (1 cm × 1 cm), reconfiguration of detector modules (a stacked-layer structure), the optimum surface treatment, and the spectral matching with customized PIN-type photodiodes. As a result, the optimum thickness of the CsI(Tl) was found to be 4.5 cm; the optimum value was 5.5 cm for the BC430. When the detector modules were stacked in a sandwich structure rather than the existing single detector structure, the light photon transmission to the surface of the photodiode was enhanced by 40% and 58% for CsI(Tl) and BC430, respectively. In the matter of scintillator surface treatment, both scintillators were simulated with unpolished and polished condition before coating. The polished condition of the scintillator surfaces showed a higher performance, more than doubling that of the unpolished condition surfaces. Then, the performance improvement of the scintillator with the paint coating was compared to the scintillator with the metal coating conditions. For CsI(Tl), the metal coating showed a 10 % higher performance than that of the paint coating, and the metal coating of BC430 showed a 6% higher performance than that of the paint coating. As a result of spectral matching between the scintillators and the customized PIN-photodiodes, PS100-6b of Silicon AG, SD445-14-21-305 of API, and FSD1010-CAL of THOLABS were compared. The spectral matching factor of PS100-6b was 0.39 with CsI(Tl) and was 0.42 with BC430; the spectral matching factors of the other samples were relatively lower (SD445-14-21-305 with CsI(Tl): 0.29; SD445-14-21-305 with BC430: 0.33; FSD1010-CAL with CsI(Tl): 0.26; FSD1010-CAL with BC430: 0.29).
    Journal of Instrumentation 04/2012; 7(04). DOI:10.1088/1748-0221/7/04/C04013 · 1.40 Impact Factor
  • Yong Ho Choi · Kwang Hyun Kim ·
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    ABSTRACT: Nanomaterials such as 1-dimensional nanowires and nanotubes and 2-dimensional graphene are the promising materials for novel device developments due to their unique physical and chemical properties. For field emission applications, nanomaterials are excellent candidate for an electron source by advantages of their small dimensions and high aspect ratios. In this study, we used GaN nanowires as the nanomaterials synthesized by Vapor-Liquid-Solid method. The field emission devices were then fabricated using the general Si microfabrication techniques. Moreover, the field emission properties of the GaN nanowires were characterized using cold field emission theory. It is demonstrated that the fabrication techniques shown in this study are efficient to fabricate field emission devices using nanomaterials.
    02/2012; 463-464:739-742. DOI:10.4028/
  • Kwang Hyun Kim · Sung Min Myoung · Yong Hyun Chung ·
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    ABSTRACT: A new concept of dual-energy X-ray beam generation and acquisition of dual-energy security radiography is proposed. Erbium (Er) and rhodium (Rh) with a copper filter were positioned in front of X-ray tube to generate low- and high-energy X-ray spectra. Low- and high-energy X-rays were guided to separately enter into two parallel detectors. Monte Carlo code of MCNPX was used to derive an optimum thickness of each filter for improved dual X-ray image quality. It was desired to provide separation ability between organic and inorganic matters for the condition of 140kVp/0.8mA as used in the security application. Acquired dual-energy X-ray beams were evaluated by the dual-energy Z-map yielding enhanced performance compared with a commercial dual-energy detector. A collimator for the parallel dual-energy X-ray beam was designed to minimize X-ray beam interference between low- and high-energy parallel beams for 500mm source-to-detector distance.
    Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment 10/2011; 652(1):66-68. DOI:10.1016/j.nima.2010.09.117 · 1.22 Impact Factor
  • Dae-Hun Jeong · Jae Myung Kim · Do Young Noh · Kwang Hyun Kim · Jong-Hyun Lee ·
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    ABSTRACT: Two-dimensional micromachined anti-scatter grids were fabricated using MEMS technology, including crystalline wet etching of (1 1 0) silicon and metal electroplating for X-ray imaging. The core sizes of the square grids were 100, 200, and 300 μm with 2.2 mm height and 50 μm septa thickness. To prepare the etch mask for crystalline wet etching, silicon nitride was deposited using low pressure chemical vapor deposition (LPCVD). The grid patterns, which are aligned parallel to the vertical (1 1 1) plane of the (1 1 0) silicon, were transferred from the photomask onto the photoresist using deep ultraviolet (DUV) photolithography, and consecutively onto the silicon nitride using reactive ion etching (RIE). A (1 1 0) silicon substrate was then etched in a tetramethyl ammonium hydroxide (TMAH) solution to form a skeleton for the septa structure. Chrome was sputtered to provide a seed layer for nickel electroplating, where nickel grows on the sidewalls of the skeleton of the septa structure. Finally, two-dimensional septa with various grid ratios were constructed by cross-stacking several layers of the patterned (1 1 0) silicon wafer. Anti-scattering ability was experimentally characterized in terms of X-ray transmission by one-dimensional scanning of incident angle.
    Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment 10/2011; 652(1):846-849. DOI:10.1016/j.nima.2010.08.116 · 1.22 Impact Factor

  • The Journal of Urology 04/2011; 185(4). DOI:10.1016/j.juro.2011.02.312 · 4.47 Impact Factor
  • Kwang Hyun Kim ·
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    ABSTRACT: This paper reports a new X-ray beam geometry to acquire two separated polychromatic X-rays as well as two separated fan beams using parallel different filters built in a single collimator. This newly designed X-ray spectrum was generated by a single X-ray shot but had the effect of double X-ray exposure. The two separated filters were used side by side. The first filter for the low energy spectra was 0.5 mm thick erbium and the second filter for the high energy spectra was composed of two layers of a 0.8 mm of copper and 0.4 mm of rhodium. This combination of filters showed excellent performance of X-ray beam hardening regardless of the bone thickness in the soft tissue under DXA conditions.
    IEEE Transactions on Nuclear Science 09/2010; 57(4-57):2155 - 2158. DOI:10.1109/TNS.2010.2050335 · 1.28 Impact Factor

Publication Stats

39 Citations
25.72 Total Impact Points

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  • 2015
    • Chonnam National University
      • Department of Animal Science
      Gwangju, Gwangju, South Korea
  • 2013-2014
    • Kangwon National University
      • • Department of Animal Resource Science
      • • College of Animal Life Sciences
      Shunsen, Gangwon-do, South Korea
  • 2012-2013
    • Konyang University
      Ronsan, Chungcheongnam-do, South Korea
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
    • University of Ulsan
      • College of Medicine
      Urusan, Ulsan, South Korea
  • 2010-2012
    • Jungwon University
      • Department of Medical Engineering
      Sŏul, Seoul, South Korea