Luis José Castro Robles

Universidad de León, León, Castile and Leon, Spain

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Publications (3)3.96 Total impact

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    ABSTRACT: To determine the pharmacokinetics of a commercial formulation of doxycycline hyclate after IM administration of a single dose to sheep. 11 healthy domestic sheep. For each sheep, doxycycline was administered as a single dose of 20 mg/kg, IM. Blood samples were obtained prior to and for 84 hours after doxycycline administration. Plasma concentrations of doxycycline were determined via high-performance liquid chromatography with UV detection. Pharmacokinetic data were analyzed with noncompartmental methods. Mean ± SD values for pharmacokinetic parameters included maximum plasma concentration (2.792 ± 0.791 μg/mL), time to reach maximum plasma concentration (0.856 ± 0.472 hours), mean residence time (91.1 ± 40.78 hours), elimination half-life (77.88 ± 28.45 hours), and area under the curve (65.67 ± 9.877 μg•h/mL). Results indicated that doxycycline had prolonged absorption and elimination in sheep after IM administration. A daily dose of 20 mg/kg would be sufficient to reach effective plasma concentrations against Chlamydia spp (minimum inhibitory concentration, 0.008 to 0.031 μg/mL) and Staphylococcus aureus (minimum inhibitory concentration, 0.12 μg/mL). Doxycycline administered IM could be an option for therapeutic use in sheep, although further studies are needed.
    American Journal of Veterinary Research 05/2012; 73(5):714-8. · 1.35 Impact Factor
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    ABSTRACT: La fibra dietética glucomanano se utiliza con cierta frecuencia en Occidente desde hace dos décadas, dadas sus demostradas acciones beneficiosas para la salud, si bien su uso se remonta, en las civilizaciones orientales, a más de mil años. Esta fibra es el principal polisacárido obtenido de los tubérculos de la planta originaria del este asiático Amorphophallus konjac y que pertenece a la familia Araceae. La estructura química del glucomanano incluye D-manosa y D-glucosa (en una proporción8:5, respectivamente), unidas por enlace ß ß (1 .4). El glucomanano es una fibra muy soluble, que posee una excepcional capacidad de captar agua, formando soluciones muy viscosas. Posee un peso molecular y una viscosidad más elevados que cualquier fibra conocida. Se ha demostrado que es eficaz en la obesidad, por la sensación de saciedad que produce; en el estreñimiento debido a que aumenta el volumen fecal; como hipocoles-terolemiante interfiriendo en el transporte de colesterol y ácidos biliares; y también disminuye los niveles de glucosa e insulina, probablemente debido a que retrasa el vaciado gástrico y, por tanto, dificulta el acceso de la glucosa a la mucosa intestinal. A estas propiedades beneficiosas, podemos añadir algunos inconvenientes como la producción de flatulencia, molestias abdominales, obstrucciones esofágicas o del tracto gastrointestinal, o incluso puede modificar la biodisponibilidad de otros fármacos que se administren al mismo tiempo que la fibra. Esta revisión recoge las principales características del glucomanano, así como sus propiedades, efectos fisiológicos y aplicaciones terapéuticas.
    Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral 01/2004; · 1.31 Impact Factor
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    ABSTRACT: Glucomannan is a dietary fiber employed quite frequently in the western countries since two decades now, as its ingestion plays an important role in human health. However, eastern people have used this fiber for more than a thousand years. This dietary fiber is the main polysaccharide obtain from the tubers of the Amorphophallus konjac plant, a member of the family Araceae found in east Asia. The chemical structure of glucomannan consists, mainly, in mannose and glucose in the ratio 8:5 linked by beta (1-->4) glycosidic bonds. This soluble fiber has a extraordinarily high waterholding capacity, forming highly viscous solutions when dissolved in water. It has the highest molecular weight and viscosity of any known dietary fiber. It has been demonstrated that this product is highly effective in the treatment of obesity due to the satiety sensation that it produces; as a remedy for constipation, because it increases the faeces volume; as hypocholesterolemic agent, interfering in the transport of cholesterol and of bile acids and as hypoglycemic and hypoinsulinemic agent, probably, by delaying gastric emptying and slowering glucose delivery to the intestinal mucosa. To the beneficial properties of this fiber, several disadvantages can be added as the production of flatulence, abdominal pain, esophageal obstruction, lower gastrointestinal obstruction or even the possible modification of the bioavailability of other drugs. This paper reviews the main characteristics of glucomannan, as well as its properties, physiologic effects and therapeutic uses.
    Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral 19(1):45-50. · 1.31 Impact Factor