Jeong Hoon Kim

Inje University, Kŭmhae, Gyeongsangnam-do, South Korea

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Publications (150)456.96 Total impact

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    ABSTRACT: Objective: Pineal parenchymal tumors (PPTs) in adults are rare, and knowledge regarding their optimal management and treatment outcome is limited. Herein, we present the clinical results of our series of PPTs other than pineoblastomas managed by stereotactic radiosurgery (SRS) at upfront setting. Methods: Between 1997 and 2014, nine consecutive adult patients with the diagnosis of PPTs, either pineocytoma or pineal parenchymal tumor of intermediate differentiation, were treated with SRS. There were 6 men and 3 women. The median age was 39 years (range, 31-53 years). All of the patients presented with symptoms of hydrocephalus. Endoscopic third ventriculostomy and biopsy was done for initial management. After histologic diagnosis, patients were treated with Gamma Knife with the mean dose of 13.3 Gy (n=3) or fractionated Cyberknife with 32 Gy (n=6). Results: After a mean follow-up of 78.6 months (range, 14-223 months), all patients were alive and all of their tumors were locally controlled except for one instance of cerebrospinal fluid seeding metastasis. On magnetic resonance images, tumor size decreased in all patients, resulting in complete response in 3 patients and partial response in 6. One patient had experienced temporary memory impairment after SRS, which improved spontaneously. Conclusion: SRS is effective and safe for PPTs in adults and can be considered as a useful alternative to surgical resection at upfront setting.
    Journal of Korean Neurosurgical Society 11/2015; 58(4):334. DOI:10.3340/jkns.2015.58.4.334 · 0.64 Impact Factor
  • Jeong Hoon Kim · Tack Geun Cho · Jae Gon Moon · Chang Hyun Kim · Ho Kook Lee ·
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    ABSTRACT: Objective: To determine the advantages of parietal approach compared to Kocher's point approach for spontaneous, oval-shaped intracerebral hemorrhage (ICH) with expansion to the parietal region. Methods: We divided patients into two groups : group A had burr holes in the parietal bone and group B had burr holes at Kocher's point. The hematoma volume, Glasgow coma scale (GCS) score, and modified Barthel Index (mBI) score were calculated. At discharge, we evaluated the patients' Glasgow outcome scale (GOS) score, modified Rankin Scale (mRS) score, motor grade, and hospitalization duration. We evaluated the patients' mBI scores and motor grades at 6 months after surgery. Results: The hematoma volume in group A was significantly less than that in group B on postoperative days 1, 3, 5, 7, 14, and 21. Group A had significantly higher GCS scores than did group B on postoperative days 1 and 3. Group A had higher mBI scores postoperatively than did group B, but the scores were not significantly different. No differences were observed for the GOS score, mRS score, motor grade at discharge, or duration of hospitalization. The mBI score of group A at 6 months after surgery was significantly higher, and more patients in group A showed muscle strength improvement. Conclusion: In oval-shaped ICH with expansion to the parietal region, the parietal approach is considered to improve the clinical symptoms at the acute phase by removing the hematoma more effectively in the early stages. The parietal approach might help promote the long-term recovery of motor power.
    Journal of Korean Neurosurgical Society 11/2015; 58(4):373. DOI:10.3340/jkns.2015.58.4.373 · 0.64 Impact Factor
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    ABSTRACT: Objective: To investigate the risks and pattern of evolution of peritumoral brain edema (PTE) after stereotactic radiosurgery (SRS) for asymptomatic intracranial meningiomas. Methods: A retrospective study was conducted on 320 patients (median age 56 years, range 24-87 years) who underwent primary Gamma Knife radiosurgery for asymptomatic meningiomas between 1998 and 2012. The median tumor volume was 2.7 cc (range 0.2-10.5 cc) and the median follow-up was 48 months (range 24-168 months). Volumetric data sets for tumors and PTE on serial MRIs were analyzed. The edema index (EI) was defined as the ratio of the volume of PTE including tumor to the tumor volume, and the relative edema indices (rEIs) were calculated from serial EIs normalized against the baseline EI. Risk factors for PTE were analyzed using logistic regression. Results: Newly developed or increased PTE was noted in 49 patients (15.3%), among whom it was symptomatic in 28 patients (8.8%). Tumor volume larger than 4.2 cc (p<0.001), hemispheric tumor location (p=0.005), and pre-treatment PTE (p<0.001) were associated with an increased risk of PTE. rEI reached its maximum value at 11 months after SRS and decreased thereafter, and symptoms resolved within 24 months in most patients (85.7%). Conclusion: Caution should be exercised in decision-making on SRS for asymptomatic meningiomas of large volume (>4.2 cc), of hemispheric location, or with pre-treatment PTE. PTE usually develops within months, reaches its maximum degree until a year, and resolves within 2 years after SRS.
    Journal of Korean Neurosurgical Society 11/2015; 58(4):379. DOI:10.3340/jkns.2015.58.4.379 · 0.64 Impact Factor
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    ABSTRACT: Objective: To investigate the efficacy and safety of fractionated stereotactic radiosurgery for large brain metastases (BMs). Methods: Between June 2011 and December 2013, a total of 38 large BMs >3.0 cm in 37 patients were treated with fractionated Cyberknife radiosurgery. These patients comprised 16 men (43.2%) and 21 women, with a median age of 60 years (range, 38-75 years). BMs originated from the lung (n=19, 51.4%), the gastrointestinal tract (n=10, 27.0%), the breast (n=5, 13.5%), and other tissues (n=3, 8.1%). The median tumor volume was 17.6 cc (range, 9.4-49.6 cc). For Cyberknife treatment, a median peripheral dose of 35 Gy (range, 30-41 Gy) was delivered in 3 to 5 fractions. Results: With a median follow-up of 10 months (range, 1-37 months), the crude local tumor control (LTC) rate was 86.8% and the estimated LTC rates at 12 and 24 months were 87.0% and 65.2%, respectively. The median overall survival (OS) and progression-free survival (PFS) rates were 16 and 11 months, respectively. The estimated OS and PFS rates at 6, 12, and 18 months were 81.1% and 65.5%, 56.8% and 44.9%, and 40.7% and 25.7%, respectively. Patient performance status and preoperative focal neurologic deficits improved in 20 of 35 (57.1%) and 12 of 17 patients (70.6%), respectively. Radiation necrosis with a toxicity grade of 2 or 3 occurred in 6 lesions (15.8%). Conclusion: These results suggest a promising role of fractionated stereotactic radiosurgery in treating large BMs in terms of both efficacy and safety.
    Journal of Korean Neurosurgical Society 11/2015; 58(3):217-24. DOI:10.3340/jkns.2015.58.3.217 · 0.64 Impact Factor
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    ABSTRACT: Background and objective: Despite advances in skull base surgery, achieving effective surgical management of jugular foramen schwannomas (JFSs) that avoids postoperative cranial nerve (CN) deficits remains a challenge. Subtotal resection followed by radiosurgery (rather than radical resection) is increasingly being viewed as a better treatment strategy. Here, an institutional database was retrospectively analyzed for outcomes after surgical treatment of JFSs to evaluate the optimal strategy for managing JFSs. Methods: Twenty-two patients with JFSs were operated on by either radical resection (n = 13) or conservative resection plus radiosurgery (n = 9). These two different groups were compared in terms of early (≤4 weeks post-surgery) and late postoperative functional outcome and oncologic control. Results: No mortalities were observed in either group, but there were three surgery-related complications in the radical resection group. Postoperative CN deficits and additional procedures related to CN morbidity were generally higher in the radical resection group, but the differences were not statistically significant. The conservative surgery group showed a statistically significant improvement in the level of dysphagia and dysphagia-related functional state in the late postoperative period. There was one case of recurrence after radical resection over a mean follow-up period of 73 months. All tumors in the conservative surgery were controlled over a mean period of 34 months. Conclusions: Our results suggest that conservative resection of JFSs via a familiar intracranial approach plus radiosurgery may be an effective surgical alternative for improving functional outcome with adequate oncologic control.
    World Neurosurgery 11/2015; DOI:10.1016/j.wneu.2015.10.042 · 2.88 Impact Factor
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    ABSTRACT: Purpose: Cell division cycle and apoptosis regulator 1 (CCAR1) plays a dynamic role in regulation of cell growth and apoptosis by serving as a cofactor of steroid/thyroid nuclear receptors, ß-catenin, and p53 in a variety of cell types including different cancer cells. However, whether CCAR1 protein is overexpressed in hepatocellular carcinoma (HCC) and the prognostic significance of CCAR1 protein expression in HCC have not been reported. Materials and methods: In 167 HCC patients with long-term follow-up, CCAR1 protein expression was examined by immunohistochemistry. Results: High CCAR1 protein expression was observed in 149 (89.2%) of the 167 HCC cases and showed significant correlation with microvascular invasion, intrahepatic metastasis, higher AJCC T-stage, and early recurrence. High CCAR1 expression showed an unfavorable effect on recurrence-free survival (RFS) (P=0.002). In subgroup analysis, among patients with α-fetoprotein ≤20 ng/mL (n=54) and patients with AJCC T-stage 1 (n=62), significant differences in RFS were observed between high CCAR1 expression groups and low CCAR1 expression groups (P=0.015 and P=0.004, respectively). High CCAR1 expression tended to be an independent predictor of shorter RFS (P=0.054) and showed an unfavorable effect on overall survival (OS) (P=0.015). In subgroup analysis, among patients with α-fetoprotein ≤ 20 ng/mL (n=54), significant difference in OS was observed between high CCAR1 expression group and low CCAR1 expression group (P=0.046). Conclusion: CCAR1 protein could be a potential biomarker predicting RFS in HCC patients after curative hepatectomy. In addition, CCAR1 had prognostic values in HCC patients with normal serum α-fetoprotein levels or early stage HCC.
    Cancer Research and Treatment 10/2015; DOI:10.4143/crt.2015.302 · 3.32 Impact Factor
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    ABSTRACT: Background: In this study, we compared the dosimetric properties between Gamma Knife (GK) and Cyberknife (CK), and investigated the clinical implications in treating brain metastases (BMs). Methods: Between 2011 and 2013, 77 patients treated with either single-fraction GK for small BMs (n = 40) or fractionated CK for large BMs >3 cm (n = 37) were analyzed. Among a total of 160 lesions, 81 were treated with GK (median, 22 Gy) and 38 (large lesions) with three- or five-fraction CK (median, 35 Gy). The median tumor volume was 1.0 cc (IQR, 0.12-4.4 cc) for GK and 17.6 cc (IQR, 12.8-23.7 cc) for fractionated CK. A lesion-to-lesion dosimetric comparison was performed using the identical contour set in both systems. Results: The mean dose to tumor was significantly higher in GK by 1.25-fold (P < 0.001), whereas normal tissue volume receiving 90-10 % of prescription dose was significantly larger in CK by 1.26-fold (P < 0.001). Nevertheless, no differences were observed in local tumor control (rates at 1 year, 89.7 % vs 87.0 %; P = 0.594) and overall survival (median, 14 vs 16 months; P = 0.493) between GK and fractionated CK groups. The incidences of radiation necrosis were also not different (12.3 % vs 15.8 %; P = 0.443). Conclusions: Despite slightly inferior dosimetric properties of CK, fractionated CK for large BMs appears to be as effective and safe as single-fraction GK for small BMs, representing fractionation as an effective strategy for enhancing efficacy and moderating toxicity in stereotactic radiosurgery for BMs.
    Acta Neurochirurgica 09/2015; 157(11). DOI:10.1007/s00701-015-2585-3 · 1.77 Impact Factor
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    ABSTRACT: The superlattice crystals–mimic, flexible/functional ceramic membrane is presented as a new ceramic-driven material/architecture opportunity for next-generation high-performance battery separators. The structural uniqueness/Mn2+-chelating ability of the ceramic membrane (comprising the close-packed, thiol groups–containing silica particles spatially besieged by the polyvinylpyrrolidone/polyacrylonitrile nanofiber skeleton) enables unprecedented improvement in the membrane properties and, more notably, the high-temperature cyclability far beyond those accessible with conventional polymeric separators.
    Advanced Energy Materials 09/2015; DOI:10.1002/aenm.201500954 · 16.15 Impact Factor
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    ABSTRACT: Tentorial meningiomas near the middle third of the medial tentorial edge with supratentorial extension are usually removed via the subtemporal approach. This approach, however, may not be practical, especially for huge tumors extending to the posterior subtemporal space. This study describes the use of the transzygomatic approach with anteriorly limited inferior temporal gyrectomy (TZ-AITG) to remove these large tumors. Between 2008 and 2012, five patients with symptomatic tentorial meningiomas (median diameter, 5.2 cm; range, 4.0-5.7 cm) near the middle third of the medial tentorial edge with supratentorial extension underwent TZ-AITG, consisting of zygomatic osteotomy, low-positioned craniotomy, and resection of the inferior temporal gyrus around 4 cm from the tip. Tumors were completely resected in all patients. Postoperatively, none had a newly developed neurological morbidity, and none died. Of three patients with preoperative hemianopia, two showed improvement and one remained stationary. One patient with preoperative hemiparesis recovered completely. All patients returned to their normal activities during the follow-up period. Surgical morbidities included epidural hematoma and chronic subdural hematoma in one patient each, with both requiring evacuation. TZ-AITG may be a good alternative to the subtemporal approach for large tentorial meningiomas near the middle third of the medial tentorial edge. TZ-AITG provides access to the lesions and visualization of the middle fossa, facilitating early feeder control while minimizing brain retraction, thus reducing potential injury to the vein of Labbé. TZ-AITG is also safe and feasible in minimizing neurological compromise.
    Acta Neurochirurgica 08/2015; 157(10). DOI:10.1007/s00701-015-2551-0 · 1.77 Impact Factor
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    ABSTRACT: Purpose To correlate and compare diagnostic performance with amide proton transfer (APT) imaging as a tumor proliferation index with that with magnetic resonance (MR) spectroscopy in subgroups of patients with pre- and posttreatment glioma. Materials and Methods This retrospective study was approved by the institutional review board. In 40 patients with pretreatment glioma and 25 patients with posttreatment glioma, correlation between APT asymmetry and the choline-to-creatine and choline-to-N-acetylaspartate ratios in corresponding voxels of interest was determined, and the 90% histogram cutoff of APT asymmetry values (APT90) for the entire solid portion of gliomas was calculated for diagnostic performance. Area under the receiver operating characteristic curve (AUC), leave-one-out cross validation, and intraclass correlation coefficients were analyzed. Results The APT asymmetry values showed a moderate correlation (r = 0.49, P < .001) with the choline-to-creatine ratios and a mild correlation with the choline-to-N-acetyl-aspartate ratios (r = 0.32, P = .011) in the corresponding lesions. The APT90 showed comparable diagnostic accuracy for grading of gliomas (AUC, 0.81-0.84 vs 0.86; P = .582-.864) and superior accuracy for differentiation of tumor progression from treatment-related change (AUC, 0.89-0.90 vs 0.60; P = .031-.046) compared with those with MR spectroscopy. The cross-validated area under the curve and accuracy of the APT90 in posttreatment gliomas were 0.89-0.90 and 72%, respectively. The interreader agreement for APT90 was excellent in both pretreatment and posttreatment gliomas (intraclass correlation coefficient, 0.95 and 0.96, respectively). Conclusion APT imaging used as a tumor proliferation index showed moderate correlation with MR spectroscopic values and is a superior imaging method to MR spectroscopy, particularly for assessment of posttreatment gliomas. (©) RSNA, 2015 Online supplemental material is available for this article.
    Radiology 08/2015; DOI:10.1148/radiol.2015142979 · 6.87 Impact Factor
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    ABSTRACT: Next generation sequencing technologies provide opportunities to reveal the genetic variants and differentially expressedgenes. The genetic variants are closely relevance to understanding of genes and phenotypic differences related to agronomic characteristics among cultivars. In this study, we conducted RNA-seq using two Korean soybean accessions, including Daewon and Hwangkeum, by using next generation sequencing against Williams 82 genome as reference. A number of variants such assingle nucleotide variants (SNV), multiple nucleotide variants (MNV), insertion/deletion (InDel) and replacement, was 34,411 and 55,544 in Daewon and Hwangkeum, respectively. Among these variants, 9,611 non-synonymous variants were detected within 4,290 genes in Daewon and 13,225 non-synonymous variants were located on 5,672 genes in Hwangkeum. The distribution of non-synonymous variants and expression values of genes can serve as invaluable resource for genotyping and study of traits within genes for soybean improvements.
    06/2015; 60(2):224-230. DOI:10.7740/kjcs.2015.60.2.224
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    ABSTRACT: Brain metastasis represents one of the most common causes of intracranial tumors in adults, and the incidence of brain metastasis continues to rise due to the increasing survival of cancer patients. Yet, the development of cystic brain metastasis remains a relatively rare occurrence. In this review, we describe the characteristics of cystic brain metastasis and evaluate the combined use of stereotactic aspiration and radiosurgery in treating large cystic brain metastasis. The results of several studies show that stereotactic radiosurgery produces comparable local tumor control and survival rates as other surgery protocols. When the size of the tumor interferes with radiosurgery, stereotactic aspiration of the metastasis should be considered to reduce the target volume as well as decreasing the chance of radiation induced necrosis and providing symptomatic relief from mass effect. The combined use of stereotactic aspiration and radiosurgery has strong implications in improving patient outcomes.
    04/2015; 3(1):1-7. DOI:10.14791/btrt.2015.3.1.1
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    ABSTRACT: Failure to achieve optimal stent expansion poses a risk of treatment failure in percutaneous coronary intervention (PCI). Although intravascular ultrasound provides useful information for suboptimal stent expansion, substantial portion of PCI are currently being performed under angiographic guidance only. : AIM: To evaluate the adequacy of stent expansion of 4 widely-used drug-eluting stents in angiography-guided PCI, we performed a retrospective analysis of lesions undergoing PCI using quantitative coronary angiography (QCA). Total 112 de novo lesions were analyzed. Minimal lumen diameter (MLD) was measured at peak pressure during stent deployment (MLD1), after stent deployment (MLD2) and after postdilatation (MLD3). Stent underexpansion, stent elastic recoil, and stent deficit were calculated. Optimal stent deployment was defined as final MLD ≥ 90% of predicted diameter. For deploying stent balloon, higher than nominal pressure was used in 83% (93/112). However, optimal deployment was observed in only 32% (36/112). Adjuvant postdilatation was performed in 59% (45/76) of lesions with suboptimal expansion, which increased the optimal deployment rate by 60% (27/45). Final optimal stent deployment rate was achieved in 56% (63/112). We newly found that the MLD1 (p=0.04), MLD3 (p=0.02), final MLD (p=0.04), and optimal stent deployment rate (p=0.036) were significantly reduced in longer stent deployment lesion (≥ : 20 mm) compared to shorter lesion (< 20 mm). Stent length may be a contributing factor of suboptimal stent expansion in angiography-guided PCI.
    Kardiologia polska 03/2015; 73(8). DOI:10.5603/KP.a2015.0034 · 0.54 Impact Factor
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    ABSTRACT: Two experiments were conducted to evaluate the nutrient composition, in vitro dry matter disappearance (IVDMD) and organic matter disappearance (IVOMD) of three kinds of distillers grains (DG); i) wet distillers grains (WDG, KRW 25/kg), ii) dried distillers grains (DDG, KRW 280/kg), iii) dried distillers grains with solubles (DDGS, KRW 270/kg) produced from tapioca 70% and rice 30%, and to evaluate dietary effects of WDG on the performance of Hanwoo steers. In Exp. 1, twelve-WDG, four-DDG and one-DDGS were collected from seven ethanol plants. Average crude protein, crude fiber, neutral detergent fiber, and acid detergent fiber of WDG, DDG, and DDGS were: 32.6%, 17.8%, 57.5%, and 30.2% for WDG, 36.7%, 13.9%, 51.4%, and 30.5% for DDG, and 31.0%, 11.9%, 40.3%, and 21.2% for DDGS (DM basis), respectively. The DDGS had a higher quantity of water-soluble fraction than WDG and DDG and showed the highest IVDMD (p<0.05) in comparison to others during the whole experimental time. The IVDMD at 0 to 12 h incubation were higher (p<0.05) in DDG than WDG, but did not show significant differences from 24 to 72 h. The same tendency was observed in IVOMD, showing that DG made from tapioca and rice (7:3) can be used as a feed ingredient for ruminants. Considering the price, WDG is a more useful feed ingredient than DDG and DDGS. In Exp. 2, 36 Hanwoo steers of 21 months (495.1±91 kg) were randomly assigned to one of three dietary treatments for 85 days; i) Control (total mixed ration, TMR), ii) WDG 10% (TMR containing 10% of WDG, as fed basis), and iii) WDG 20% (TMR containing 20% of WDG, as fed basis). With respect to body weight and average daily gain, there were no differences between control and WDG treatments during the whole experimental period. Dry matter intake of control (9.34 kg), WDG 10% (9.21 kg) and 20% (8.86 kg) and feed conversion ratio of control (13.0), WDG 10% (13.2) and 20% (12.1) did not show differences between control and WDG treatments. Thus, the use of WDG up to 20% in TMR did not show any negative effect on the performance of Hanwoo steers.
    Asian Australasian Journal of Animal Sciences 02/2015; 28(5). DOI:10.5713/ajas.14.0592 · 0.54 Impact Factor
  • Ji Eun Park · Ho Sung Kim · Myeong Ju Goh · Sang Joon Kim · Jeong Hoon Kim ·
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    ABSTRACT: Purpose: To validate a volume-weighted voxel-based multiparametric clustering (VVMC) method for magnetic resonance imaging data that is designed to differentiate between pseudoprogression and early tumor progression (ETP) in patients with glioblastoma in an independent test set. Materials and methods: This retrospective study was approved by the local institutional review board, with waiver of the need to obtain informed consent. The study patients were grouped chronologically into a training set (108 patients) and a test set (54 patients). The reference standard was pathologic findings or subsequent clinical-radiologic study results. By using the optimal cutoff determined in the training set, the diagnostic performance of VVMC was subsequently tested in the test set and was compared with that of single-parameter measurements (apparent diffusion coefficient [ADC], normalized cerebral blood volume [nCBV], and initial area under the time-signal intensity curve). Results: Interreader agreement was highest for VVMC (intraclass correlation coefficient, 0.87-0.89). Receiver operating characteristic curve analysis revealed that VVMC performed the best as a classifier, although statistical significance was not demonstrated with respect to the nCBV in the training set. In the test set, the diagnostic accuracy of VVMC was higher than that of any single-parameter measurements, but this trend reached significance only for the ADC. When the entire population was considered, VVMC had significantly better diagnostic accuracy than did any single parameter (P = .003-.046 for reader 1; P = .002-.016 for reader 2). Results of fivefold cross validation confirmed the trends in both the training set and the test set. Conclusion: VVMC is a superior and more reproducible imaging biomarker than single-parameter measurements for differentiating between pseudoprogression and ETP in patients with glioblastoma. Online supplemental material is available for this article.
    Radiology 01/2015; 275(3):141414. DOI:10.1148/radiol.14141414 · 6.87 Impact Factor
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    ABSTRACT: CD10 expression was identified as a contributor to cancer progression in several cancers; however, the exact biological significance and mechanism of CD10 expression remains unclear. In addition, CD10 expression in esophageal squamous cell carcinoma (ESCC) has not been studied. We investigated the relationship between CD10 and Twist1. Furthermore, we examined the effect of CD10 on tumorigenicity using in vivo and in vitro systems as well as establishing the clinical significance of CD10 expression in ESCC using large clinical samples. CD10 expression was up-regulated by Twist1 and there was a strong correlation between mRNA and protein expression. Twist1 can specifically up-regulate CD10 at the transcriptional level via an interaction with the promoter region of CD10 and the proximal E-box CAGGTG in the CD10 promoter was identified as a binding site for Twist1. CD10 is frequently expressed in ESCC cell lines and silencing CD10 suppresses migration/invasion and anchorage-independent tumor growth of ESCC cells. Knockdown of CD10 inhibits the growth of ESCC xenograft in nude mice, suggesting that CD10 plays a role in enhancing the tumorigenesis of ESCC. From among 153 ESCC samples, 46 (30.0%) showed varying degrees of CD10 expression in cancer cells. In addition, stromal fibroblasts also showed varying amounts of CD10 expression in 92 (60.9%) tumor samples. CD10 overexpression in cancer cells as well as in stromal fibroblasts was an independent poor prognostic factor in both overall survival and disease-free survival. CD10 could be a promising target for the treatment of ESCC. © 2014 Wiley Periodicals, Inc.
    International Journal of Cancer 01/2015; 136(2). DOI:10.1002/ijc.29006 · 5.09 Impact Factor
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    ABSTRACT: Object: Brain metastases from hepatocellular carcinoma (HCC) are rare, and the evidence of the effectiveness of Gamma Knife surgery (GKS) in this disease is lacking. The authors report their institutional experience with GKS in patients with brain metastases from HCCs. Methods: The authors retrospectively reviewed the medical records of 73 consecutive patients who had a combined total of 141 brain metastases arising from HCCs and were treated with GKS. Sixty-four (87.7%) patients were male, and the mean age of the patients was 52.5 years (range 30-79 years). The mean tumor volume was 7.35 cm(3) (range 0.19-33.7 cm(3)). The median margin dose prescribed was 23 Gy (range 15-32 Gy). Univariate and multivariate survival analyses were performed to identify possible prognostic factors of outcomes. Results: The estimated rate of local tumor control was 79.6% at 3 months after GKS. The median overall survival time after GKS was 16 weeks. The actuarial survival rates were 76.7%, 58.9%, and 26.0% at 4, 12, and 24 weeks after GKS, respectively. In the univariate analysis, an age of ≤ 65 years, Child-Pugh Class A (pertaining to liver function), high Karnofsky Performance Scale score (≥ 70), and low Radiation Therapy Oncology Group recursive partitioning analysis class (I or II) were positively associated with the survival times of patients. No statistically significant variable was identified in the multivariate analysis. Conclusions: Although survival was extremely poor in patients with brain metastases from HCCs, GKS showed acceptable local tumor control at 3 months after the treatment. The authors suggest that GKS represents a noninvasive approach that may provide a valuable option for treating patients with brain metastases from HCCs.
    Journal of Neurosurgery 12/2014; 121 Suppl 2:102-9. DOI:10.3171/2014.7.GKS141507 · 3.74 Impact Factor
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    ABSTRACT: Smad3 functions as an integrator of diverse signaling, including transforming growth factor beta signaling and the function of Smad3 is complexly regulated by differential phosphorylation at various sites of Smad3. Despite the importance of Smad3 and its various phosphoisoforms, their prognostic significance has rarely been studied. In this study, we demonstrated the prognostic significance of Smad3, its phosphoisoforms, and Smad4 expression by immunohistochemistry in 126 esophageal squamous cell carcinomas. The phosphoisoforms of Smad3 studied in this article included phosphorylation at C-terminal (pSmad3C)(Ser(423/425)) and phosphorylation at the linker region (pSmad3L)(Ser(213)). High expression of Smad3 was associated with shorter overall survival. Coexistence of high expression of pSmad3L(S213) and low expression of pSmad3C(S423/425) were associated with advanced N stage and an independent prognostic factor for overall [hazard ratio (HR) 2.03, 95 % confidence interval (CI) (1.10-3.75), p = 0.023] and disease-free survival [HR 2.41, 95 % CI (1.32-4.39), p = 0.004]. In conclusion, coexistence of high pSmad3L(Ser(213)) expression and low pSmad3C(Ser(423/425)) expression can be considered as immunohistochemical biomarkers for predicting prognosis as well as future therapeutic targets. In addition, our results of combinatory effect of differential phosphorylation of Smad3 on prognosis suggest the mode of action of Smad3 might be logically determined by its phosphorylation pattern.
    Medical Oncology 11/2014; 31(11). DOI:10.1007/s12032-014-0236-9 · 2.63 Impact Factor
  • Jeong‐Hoon Kim · Jungwoo Lee · Song‐Ping Zhu · Seok‐Hyon Yu ·
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    ABSTRACT: Based on a new multiscale hybrid structure of the volatility of the underlying asset price, we study the pricing of a European option in such a way that the resultant option price has a desirable correction to the Black–Scholes formula. The correction effects are obtained by asymptotic analysis based upon the Ornstein–Uhlenbeck diffusion that decorrelates rapidly while fluctuating on a fast time-scale. The subsequent implied volatilities demonstrate a smile effect (right geometry), which overcomes the major drawback of the Black–Scholes model as well as local volatility models, and move to a right direction as the underlying asset price increases (right dynamics), which fits the observed market behavior and removes the possible instability of hedging that the local volatility models may cope with. Further, we demonstrate that our correction brings significant improvement in terms of fitting to the implied volatility surface through a calibration exercise. Copyright © 2014 John Wiley & Sons, Ltd.
    Applied Stochastic Models in Business and Industry 11/2014; 30(6). DOI:10.1002/asmb.2006 · 0.73 Impact Factor
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    So-Young Yeo · Sang Yun Ha · Eun Ji Yu · Keun-Woo Lee · Jeong Hoon Kim · Seok-Hyung Kim ·
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    ABSTRACT: Zinc finger protein 282 (ZNF282) is a newly identified transcription factor and little is known about its expression and function. Originally, ZNF282 is known to bind U5RE (U5 repressive element) of HLTV-1 (human T cell leukemia virus type 1) with a repressive effect. Recently we reported that ZNF282 functions as an estrogen receptor co-activator and plays an essential role in breast tumorigenesis. Although these results suggest the possible role of ZNF282 in cancers, clinical significance and function of ZNF282 are completely unknown in most of cancers. Here we found that ZNF282 was frequently overexpressed in esophageal squamous cell carcinoma (ESCC) (n=165) compared with normal esophageal epithelium and its overexpression was correlated with adverse clinical outcome. Multivariate survival analysis indicated that ZNF282 expression was an independent prognostic predictor for poor survival in ESCC (HR: 2.56 (95% CI 1.54-4.26), p<0.001). In addition, depletion of ZNF282 inhibited the cell cycle progression, migration, and invasion of ESCC cells and reduced the tumorigenicity of ESCC xenograft in nude mouse. We further showed that ZNF282 is required for E2F1-mediated gene expression in ESCC cells. Thus, ZNF282 is E2F1 co-activator involved in ESCC and elevated expression of ZNF282 is an independent adverse prognostic factor in ESCC.
    Oncotarget 10/2014; 5(23). DOI:10.18632/oncotarget.2630 · 6.36 Impact Factor

Publication Stats

2k Citations
456.96 Total Impact Points


  • 2011-2015
    • Inje University
      • College of Medicine
      Kŭmhae, Gyeongsangnam-do, South Korea
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
    • Hanyang University
      Sŏul, Seoul, South Korea
  • 2009-2015
    • Sungkyunkwan University
      • Department of Pathology
      Sŏul, Seoul, South Korea
    • University of California, Los Angeles
      Los Ángeles, California, United States
  • 2014
    • Ulsan National Institute of Science and Technology
      Urusan, Ulsan, South Korea
    • Bundang Jesaeng Hospital
      Sŏngnam, Gyeonggi-do, South Korea
    • Yonsei University
      • Department of Mathematics
      Sŏul, Seoul, South Korea
  • 2012-2014
    • Korea Research Institute of Bioscience and Biotechnology KRIBB
      • Medical Proteomics Research Center
      안산시, Gyeonggi-do, South Korea
    • Korea Polar Research Institute
      Sŏul, Seoul, South Korea
  • 2011-2014
    • Kosin University
      • College of Medicine
      Tsau-liang-hai, Busan, South Korea
  • 2010-2014
    • Inje University Paik Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • University of Louisville
      • Department of Chemical Engineering
      Louisville, Kentucky, United States
  • 2005-2014
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2003-2014
    • University of Ulsan
      • • Asan Medical Center
      • • College of Medicine
      Urusan, Ulsan, South Korea
    • Gwangju Institute of Science and Technology
      • School of Information and Communications
      Gwangju, Gwangju, South Korea
  • 2013
    • CHA University
      • Department of Neurology
      Sŏul, Seoul, South Korea
  • 2011-2013
    • Asan Medical Center
      • Department of Neurological Surgery
      Sŏul, Seoul, South Korea
  • 2010-2011
    • Kyungpook National University
      • • Department of Electrical Engineering
      • • School of Computer Science and Engineering
      Daikyū, Daegu, South Korea
  • 2003-2008
    • University of Southern California
      • • Department of Biochemistry and Molecular Biology
      • • Department of Pathology
      Los Angeles, California, United States
  • 2007
    • Seoul National University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2006
    • Pusan National University
      • Department of Mechanical Engineering
      Tsau-liang-hai, Busan, South Korea
    • Cheju Halla University
      Tse-tsiu, Jeju, South Korea
  • 2002
    • University of Chicago
      Chicago, Illinois, United States