Publications (2)2.13 Total impact

  • P. Zha · K.-P. Feng · Y.-H. Ma · Y. Zhang · Y.-Y. Li · G.-Y. Liu · J.-X. Xue · T.-L. Wang ·
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    ABSTRACT: Objective: To investigate the use of dexmedetomidine (Dex) in intratracheal intubation with fiberoptic bronchoscope (FOB) in thyroid surgeries under general anesthesia. Methods: Eighty ASA I~III patients (20 male, 60 female) aged 29~71 years weighing 45~80 kg scheduled for thyroid surgery under general anesthesia with tracheal intubation were randomly divided into Dex group(group D) and placebo group(group P)(n=40 each). Before induction, patients of the two groups received Dex(group D, 1 μg·kg-1, 4 μg·mL-1)or same volume of normal saline(group P) infusion for 15 min, respectively. After induction of anesthesia, orotracheal intubation was performed with FOB.BP, HR, and BIS were recorded noninvasively at 5 min after entrance to the operation room, the time before induction, the time before and just the time of tracheal intubation and at 1, 2, 3, 5, 10 min after tracheal intubafion. Hemodynamic response and complications of intratracheal intubation were observed. Results: The hemodynamic responses to intubation were significantly different between group P and group D (P<0.05). Less complications of intubation were observed in group D compared with group P(but P>0.05). Conclusion: Infusion of Dex before induction can prevent the hemodynamic responses to intubation with FOB, thus reduce relevant complications. ©, 2015, Chinese Journal of New Drugs Co. Ltd. All right reserved.
    Chinese Journal of New Drugs 02/2015; 24(4):434-438.
  • F Lan · YH Ma · J X Xue · T L Wang · D Q Ma ·
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    ABSTRACT: Transcutaneous electrical nerve stimulation (TENS) is regarded as an effective treatment for various types of pain. However, no randomized controlled trial has investigated TENS on acupoints for postoperative analgesia in elderly patients. This study aim to investigate whether TENS on acupoints has any favorable effect on complementary analgesia after total hip arthroplasty (THA) for elderly patients compared with a sham control treatment. Sixty-eight elderly patients requiring THA surgery were enrolled and randomly allocated to one of two groups. Group Acu received true TENS on acupoints (bilateral P6, L14; ST36, GB31 ipsilateral to the surgery site) and Group Sham received sham treatment. All patients received patient-controlled analgesia for two days postoperatively. Analgesia was assessed by postoperative fentanyl requirement and pain intensity using a visual analogue scale (VAS-10 cm). The incidence of analgesia-related side effects, optional medication use and effects of patients' blinding were recorded. Fentanyl consumption in Group Acu was lower than that in Group Sham at 24 h (mean ± SD; 360±117 vs. 572±132 μg; P<0.001) and 48 h (712±184 vs. 1022±197 μg; P<0.001) after surgery. Postoperative pain intensity measured by VAS was similar in both groups. The incidence of opioid-related side effects and rescue medication for postoperative analgesia was significantly higher in Group Sham than in Group Acu. Differences between the groups regarding the effects of patients' blinding were not significant. TENS on specific acupoints is an effective and complementary approach to reduce postoperative analgesic requirement in elderly patients after THA.
    Minerva anestesiologica 04/2012; 78(8):887-95. · 2.13 Impact Factor