Hideyuki Yamatoya

Yamaguchi University, Yamaguti, Yamaguchi, Japan

Are you Hideyuki Yamatoya?

Claim your profile

Publications (2)2.34 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to collect data on immunological parameters from Wistar Hannover rats at 8, 10, 19, and 32 weeks of age. Low leukocyte parameter cell counts, serum globulin concentration, and T, B, and NK lymphocyte counts in peripheral blood at each time point; low T, B, and NK splenocyte counts; and high, or tendencies toward high, thymocyte counts at 10 weeks of age were noted in females when compared with males. KLH-specific antibody production increased gradually with age in both sexes. The immunological data noted for leukocyte parameters, the serum globulin concentration, and immunophenotyping (peripheral blood, spleen, and thymus) relating to chronological changes and sex differences may be useful in assessing drug-related immunotoxicity in this strain.
    Experimental Animals 01/2012; 61(2):171-5. DOI:10.1538/expanim.61.171 · 1.17 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to collect data on chronological changes in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes from Wistar Hannover rats at 8, 10, 19, and 32 weeks of age. The serum triglyceride concentration and the serum LDL cholesterol level were higher in males than in females at all ages. In contrast, serum total protein and creatinine concentrations and cholinesterase activity were lower in males than in females. In addition, sex differences were confirmed in pituitary weight and hepatic CYP3A2 and CYP2C11 activities. In conclusion, the general toxicological data noted in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes relating to chronological changes and sex differences may be useful in assessing drug-related toxicity in this strain.
    Experimental Animals 01/2012; 61(4):467-76. DOI:10.1538/expanim.61.467 · 1.17 Impact Factor