S. Takahashi

Publications (3)3.84 Total impact

• Article: Differential single living cell refractometry using grating resonant cavity with optical trap

  L. K. Chin, A. Q. Liu, X. M. Zhang, C. S. Lim, J. H. Ng, J. Z. Hao, S. Takahashi
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  ABSTRACT: This letter reports the measurement of single living cell’s refractive index �RI� using the optical grating resonant cavity with buffer modulation on a biochip. The cell’s RI is a significant cell biophysical property which has potential in cancer and disease diagnoses. The single cell is trapped optically within the cavity, and the transmission spectra shift due to the change of surrounding buffer, without/with cell, are used to determine the cell’s effective RI and effective thickness. The measurement shows that Madin-Darby canine kidney cell has an effective RI of 1.383±0.001. Moreover, the optical trapping technique eliminates uncertainty and avoids cell damage.
  Applied Physics Letters 12/2007; 91(24):243901. · 3.84 Impact Factor
• Source

  Available from: edu.sg

  Conference Proceeding: Single Living Cell Refractometry using FBG-Based Resonant Cavity

  L.K. Chin, C.S. Lim, P.H. Yap, J.H. Ng, J.Z. Hao, S. Takahashi, A.Q. Liu
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  ABSTRACT: This paper reports a single cell refractometer consists of FBG fiber-based resonant cavity by employing buffer modulation method. In this biophotonic chip, single cell is trapped optically in the cavity, and the transmission spectral shifts due to the change of surrounding buffer, without and with cell, are used to determine the cell's refractive index (Rl) and size. The measurement shows that MDCK cell has an effective Rl of 1.383 at a precision of 0.1%. Moreover, the measurement method with optical trapping eliminates uncertain factors and prevents cell damage. The chip is promising for label-free cell measurement and further cell analysis.
  Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International; 07/2007
• Source

  Available from: ntu.edu.sg

  Article: Single living cell refractometry using FBG-based resonant cavity

  L K Chin, C S Lim, P H Yap, J H Ng, J Z Hao, S Takahashi, A Q Liu
  [show abstract] [hide abstract]
  ABSTRACT: This paper reports a single cell refractometer consists of FBG fiber-based resonant cavity by employing buffer modulation method. In this biophotonic chip, single cell is trapped optically in the cavity, and the transmission spectral shifts due to the change of surrounding buffer, without and with cell, are used to determine the cell's refractive index (RI) and size. The measurement shows that MDCK cell has an effective RI of 1.383 at a precision of 0.1%. Moreover, the measurement method with optical trapping eliminates uncertain factors and prevents cell damage. The chip is promising for label-free cell measurement and further cell analysis.
  07/2002;