Mehmet Melek

Yuzuncu Yil University , Van, Van, Turkey

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Publications (13)7.51 Total impact

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    ABSTRACT: Frequent reporting of cases of the coexistence of a Spigelian hernia (SH) with an undescended testis (UT) suggests that this phenomenon may be a syndrome. In this article, four pediatric cases in which an UT accompanies a congenital SH have been discussed in light of the literature. In this study, four cases aged between 6 months and 5 years who had a SH accompanied by an UT were evaluated and underwent surgery. The patient's ages were 6 months, 1 year, 2 years, and 5 years old. The testis was observed in the opened hernia sac. The patients did not have a gubernaculum or an inguinal canal on the side of the hernia. Neither the theories suggesting that SH leads to an UT nor those suggesting that an UT leads to a SH are satisfactory. We believe that this coexistence may be the congenital Spigelian-cryptorchidism syndrome seen in boys. As in the four cases presented here, elements of this syndrome are defects in the Spigelian fascia and the hernia sac enveloping the testis and an absence of the gubernaculum and the inguinal canal.
    European Journal of Pediatric Surgery 04/2012; 22(2):157-61. · 0.84 Impact Factor
  • The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology 04/2012; 23(2):188-9. · 0.48 Impact Factor
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    ABSTRACT: To measure the oxidant/antioxidant status of newborn babies with oesophageal atresia and their mothers, compared with healthy control subjects. This case-control study included 40 participants: 10 newborns with oesophageal atresia and their mothers, and 10 healthy newborns and their mothers. Whole blood malondialdehyde (MDA) levels and the activities of antioxidant enzymes (catalase, carbonic anhydrase [CA], glucose-6-phosphate dehydrogenase [G-6-PD], and superoxide dismutase [SOD]) were measured. MDA levels and CA activity were significantly higher, and catalase, SOD and G-6-PD activities were significantly lower, in newborns with oesophageal atresia and their mothers than in healthy newborns and their mothers. Although CA activity was similar between the newborns and mothers in the patient group, it was significantly lower in newborns than in mothers in the healthy group. Increased lipid peroxidation might play an important role in the pathogenesis of oesophageal atresia. Impairment of the free radical/antioxidant balance may lead to increased free radical and decreased antioxidant levels in oesophageal atresia.
    The Journal of international medical research 01/2012; 40(1):249-57. · 0.96 Impact Factor
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    ABSTRACT: To investigate the role of erythrocyte free radical scavenging enzyme activities (FRSE), carbonic anhydrase (CA) activity and malondialdehyde (MDA) in infants with myelomeningocele (MM). We compared antioxidant enzyme activities and MDA level in 40 individuals (10 infants with MM, 10 healthy infants; and mothers of these two groups) with age-matched subjects. Erythrocyte FRSE included catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-S- transferase (GST). CA, CAT, SOD, GPX and GST concentrations were lower in all of the infants with MM compared to healthy infants. The mothers of infants with MM also had lower CA, CAT, SOD, GPX and GST activities than healthy mothers. It was also found out that the MDA level as a marker of oxidative damage was higher in infants with MM and their mothers than in healthy infants and their mothers. Lower FRSE activities indicate an increased frequency of MM. Free radicals (FRs) such as MDA may play a significant role in the etiology of MM.
    Turkish neurosurgery 01/2012; 22(3):300-4. · 0.58 Impact Factor
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    ABSTRACT: In Henoch-Schönlein purpura (HSP), involvement of the ileum and ascending colon with vasculitis can mimic appendicitis and cause unnecessary appendicectomy. A 13-year-old boy presented with signs of HSP and abdominal pain. He was treated with prednisolone (2 mg/kg/day) for 10 days, but there was no improvement. At laparotomy he had acute suppurative appendicitis. A 12-year-old girl presented with HSP associated with abdominal pain and bloody diarrhoea and at laparotomy was also found to have suppurative appendicitis. Both patients had vasculitic areas in the ileum. In HSP, although suppurative appendicitis is rare, it should always be considered and appropriate investigations, including ultrasonography, undertaken.
    Paediatrics and international child health. 01/2012; 32(4):244-5.
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    ABSTRACT: The clinical diagnosis of acute appendicitis (AA) in children is still problematic in status. To investigate the diagnostic value of mean platelet volume (MPV) in acute AA at childhood. One hundred patients diagnosed as AA patients and 100 healthy individuals. Laboratory tests were studied in the hematology laboratory of the hospital. The MPV was found to be lower than normal in 48 cases in the AA group, and it was normal or higher than normal in 52 cases. In the control group, while MPV was found to be lower than normal in 13 cases, it was normal or higher than normal in 87 cases. The MPV was significantly lower in the AA group compared to the control group (p<0.001). Our study indicated that MPV significantly decreased in pediatric AA patients. Hence, we believe that taking the MPV decrease into consideration along with the White Blood Cell Count elevation would be beneficial in patients with suspicion of AA.
    African health sciences 09/2011; 11(3):427-32.
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    Mehmet Melek, Ufuk Cobanoglu
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    ABSTRACT: Anastomotic strictures are common and important problems following repair procedures of esophageal atresia. We hereby defined an anastomosis technique that could efficiently prevent this complication in 11 patients with esophageal atresia (EA) and tracheoesophageal fistula (TEF). The proximal end of the atretic esophagus was opened with a plus ("+")-shaped incision providing sufficient anastomosis width. Longitudinal incisions of 2 mm length were made on the anterior and posterior parts of the distal end according to the patients. The two ends were anastomosed with a primary suture at a single plain. We performed this technique on 11 patients, and in the 4-year follow-up period no dilatation proved necessary in any of our patients due to anastomotic strictures or symptomatic dysphagia. This technique that we have described provides a large zigzag anastomosis line and in this way minimizes the incidence of stricture formation. Furthermore, this technique, which we believe to have provided a new opinion on the topic of how to open the proximal end of an atretic esophagus, is quite easy and effective.
    Gastroenterology Research and Practice 01/2011; 2011:527323. · 1.62 Impact Factor
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    ABSTRACT: Clinical approach and therapeutic methods are important in cases with complicated hydatid cysts of the lung. This study was designed to retrospectively investigate cases with hydatid cysts, thereby discussing diagnostic methods, treatment modalities, and rates of morbidity and mortality in line with the literature. 176 cases with perforated hydatid cysts, who presented to our clinic and underwent surgery between 2003 and 2011, were included in the study. There were 71 (40.34%) females and 105 males (59.66%) with a mean age of 27.80±14.07. The most common symptom was dyspnea (44.31%) and the most common radiological finding was the water lily sign (21.02%). 88.06% of the cases were surgically treated by Cystotomy+closure of bronchial opening+ capitonnage, 3.97% by wedge resection, 4.54% by segmentectomy and 3.40% by lobectomy. The cysts exhibited multiple localization in 24 cases (13.63%), bilateral localization in 14 cases (7.95%), with the most common localization (43.75%) being the right lower lobe. While the hydatid cyst rupture occurred due to delivery in three (1.70%), trauma in 11 (6.25%), and iatrogenic causes in seven (3.97%) cases, it occurred spontaneously in the rest of the cases (88.08%). Fourteen of the cases with spontaneously occurring rupture (7.95%) were detected to have received anthelmintic treatment for hydatid cyst during the preoperative period (albendazole). The rate of morbidity was 27.27% and the rate of mortality was 1.13% in our study. Two cases recurred during a one-year follow-up (1.13%). Hydatid cyst rupture should be considered in the differential diagnosis of cases with pleural effusion, empyema, pneumothorax and pneumonia occurring in endemic regions. Symptoms occurring during and after perforation lead to errors in differential diagnosis. Performing the surgery without delay favorably affects postoperative morbidity and mortality. While parenchyma-preserving surgery is preferential, there is a need for resection in perforated hydatid cysts.
    International Journal of Clinical and Experimental Medicine 01/2011; 4(3):220-6. · 1.42 Impact Factor
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    ABSTRACT: This study aims to examine trends of injuries due to landmines and unexploded ordnance (UXO) and to determine problems during and after the treatment of children and adolescent victims in Turkey. Data from the records of 23 children injured from landmines and UXO were analyzed from April 2001 to October 2008. Cases consist of 21 (91.3%) males and two (8.7%) females with a mean age of 12.8 years. Cause of injury was landmine explosion in 20 (87.0%) and UXO in three (13.0%) cases. Injuries in upper and lower extremities were determined in eight (34.8%) children. Hand amputation was the result in 10 (43.5%) children where in two cases a leg, in one case an eye, in one case a hand and arm, in two cases a hand and leg, in one case an eye and a leg and in three cases a hand and eye were lost. One case of death was recorded from UXO with an autopsy performed. Contaminated areas in our region should be cleared according to international contracts to prevent injuries in children, centers providing rehabilitation services should be established and policies regarding social support for child victims should be ascertained.
    Journal of forensic and legal medicine 11/2009; 16(8):464-8.
  • Ufuk Cobanoglu, Mehmet Melek, Yesim Edirne
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    ABSTRACT: The study compares the efficiency, side effects and complications of autologous blood pleurodesis with talcum powder and tetracycline. This prospective study evaluated 50 patients with persistent air leak resulting from primary and secssondary spontaneous pneumothorax between February 2004 and March 2009. The patients inclussded 32 (64.0%) males and 18 (36.0%) females with a median age of 39 years (range 14-69 years). All cases had persistent air leak of more than seven days. Pleurodesis was performed using autologous blood in 20 (40.0%) patients, talc powder in 19 (38.0%) patients and tetracycline in 11 (22.0%) patients through a chest tube. Air leak cessation times after pleurodesis, side effects and pulmonary function tests (PFT) in the first and third months were measured. Recurrent primary spontaneous pneumothorax was the cause of persistent air leak in all cases. Air leaks were expiratory only in 54.0% of cases. We obtained a success rate of 75.0% using autologous blood, 84.2% using talc powder and 63.6% using tetracycline. Mean air leak termination interval was significantly (P < 0.001) shorter in patients treated with autologous blood in comparison to talc powder and tetracycline. We observed a significant (P < 0.05) decline in PFT in patients treated with talc powder compared with tetracycline and autologous blood. Vital capacity, FVC and FEV₁were significantly lower in patients treated with tetracycline compared with autologous blood. This study shows that autologous blood pleurodesis compared to talc powder and tetracycline is related with shorter leak cessation time and less pulmonary function decline in patients with persistent air leak. We think further randomized clinical trials of pleurodesis as treatment could increase its use in thorax surgery by demonstrating the safety and the efficacy of this procedure.
    Annals of thoracic medicine. 10/2009; 4(4):182-6.
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    ABSTRACT: Megacystis Microcolon Intestinal Hypoperistalsis Syndrom (MMIHS) is a quite rare congenital and fatal disease which was firstly defined by Berdon and his colleagues. It appears through a widely enlarged bladder and microcolon and its cause is unknown (Berdon et al., 1976; Carmelo et al., 2005; Makhija et al., 1999; Loening-Baucke and Kimura 1999; Redman et al., 1984; Hsu et al., 2003; Yigit et al., 1996; Srikanth et al., 1993). The disease is found in females three or four times more than in males (Srikanth et al., 1993; Sen et al., 1993; Hirato et al., 2003). Most of the cases die within the early months of their lives (Yigit et al., 1996; Srikanth et al., 1993; Sen et al., 1993; Hirato et al., 2003). We present the case of a female newborn with antenatal ultrasound revealing intestinal mass and bilateral hydroureteronephrosis. The case was admitted for intestinal obstruction after birth.
    Gastroenterology Research and Practice 01/2009; 2009:282753. · 1.62 Impact Factor
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    Ufuk Cobanoglu, Muhammet Can, Mehmet Melek
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    ABSTRACT: ObjectivesThis study aims to display the increase in turban pin aspirations noticed in the last years and to discuss the clinical characteristics and results of turban pin aspirations in children. MethodsA retrospective study was done to asses data about turban pin aspirations in 21 female children aged below 18 between 2004–2009. Data about patient story, age, educational level, admission interval, physical examination results, radiological images, foreign body localization, treatment methods, morbidity and mortality were evaluated. ResultsMean age was 13.47±2.52 years. Eleven (52.4%) girls were aged between 12–15 years. We used rigid bronchoscopy in 15 (71.4%) cases, thoracotomy in three (14.3%) cases, laryngoscopy in one (4.8%) cases and fiber-optic bronchoscopy in two (9.6%) case for the removal of the needles. Turban pins were located in the right bronchial tree in 12 (57.1%), in the left bronchial tree in three (14.3%), in the trachea in five (23.8%) cases and in the larynx in one (4.8%) case. Eight (38.1%) cases lived in a rural area and 13 (61.9%) were urban. ConclusionWe recommend safer methods such as the use of adhesive tapes and snap fasteners and to avoid holding the needles with the lips for those that are not accepting unveiling. Key wordsChild-Foreign body-Bronchoscopy
    Indian Journal of Thoracic and Cardiovascular Surgery 26(1):20-23.
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    Ufuk Cobanoglu, Mehmet Melek, Yesim Edirne
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    ABSTRACT: BackgroundThe aim of this study is to compare morbidity and mortality rates of patients with Chest Radiography (CXR) proven pulmonary contusion and normal CXR but pulmonary contusion on contrast Computed Tomography (CT). MethodsCases were divided into two groups according to diagnosing method: CXR-proven (CXR-group) and CT-only diagnosed pulmonary contusion group (CT-group). Groups were compared for Injury Severity Score (ISS), Length Of Stay in Hospital (LOSH), length of stay in Intensive Care Unit (ICU), Arterial Blood Gas (ABG) changes, andmorbidity and mortality rates. ResultsMean LOSH and LOSI were significantly longer (23.09 ±4.01 and 13.42 ±3.47) in CXR group than in the CT group (10.97±3.27 and 3.59±1.54). Mean ISS score was significantly higher in the CXR group (38.63±19.37) than in the CT group (22.74±18.00). Mean ABG results were significantly poorer in the CXR group than in the CT group. The percentage of the cases requiring mechanic ventilation was 54.5% in the CXR group. Morbidity and mortality rates were 45.4% and 27.7% in the CXR group and 10.8% and 4.3% in the CT group, respectively. ConclusionDiagnosis of pulmonary contusion by CXR is associated with higher morbidity and mortality rates. Key wordsPulmonary-Chest-Computed tomography
    Indian Journal of Thoracic and Cardiovascular Surgery 26(1):24-29.