Jin Woo Park

Yeungnam University, 경산시, Gyeongsangbuk-do, South Korea

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Publications (120)227.72 Total impact

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    ABSTRACT: Histone H3S10 phosphorylation has been known as a cell cycle-specific marker and has a role in transcriptional activation. Various kinases phosphorylate H3S10 in different species, however, the role of the mitotic serine/threonine protein kinase Aurora A (AURKA) is largely unknown. Here we present evidence that AURKA phosphorylates H3S10 and activates target gene transcription. We show that down-regulation of AURKA level during leukemia cell differentiation results in decreased H3S10 phosphorylation level. We further show that AURKA is recruited to target gene promoters and activates transcription via H3S10 phosphorylation. Furthermore, this recruitment can be disrupted by the AURKA inhibitor Alisertib and results in H3K9-me2 recruitment by G9a.
    Biochemical and Biophysical Research Communications 11/2015; DOI:10.1016/j.bbrc.2015.11.063 · 2.30 Impact Factor
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    ABSTRACT: We assessed the possibility of changing the route of administration of zoledronic acid to an oral dosage form and its therapeutic efficacy in an estrogen-deficient osteoporosis rat model. To enhance oral bioavailability, we formed an ionic complex by electrostatic conjugation of zoledronic acid with lysine-linked deoxycholic acid (Lys-DOCA, an oral absorption enhancer). After forming the complex, the characteristic crystalline features of pure zoledronic acid disappeared completely in the powder X-ray diffractogram and differential scanning calorimetry thermogram, indicating that zoledronic acid existed in an amorphous form in the complex. In vitro permeabilities of zoledronic acid/Lys-DOCA (1:1) (ZD1) and zoledronic acid/Lys-DOCA (1:2) (ZD2) complex across Caco-2 cell monolayers were 2.47- and 4.74-fold higher than that of zoledronic acid, respectively. Upon intra-jejunal administration to rats, the intestinal absorption of zoledronic acid was increased significantly and the resulting oral bioavailability of the ZD2 complex was determined to be 6.76±2.59% (0.548±0.161% for zoledronic acid). Ovariectomized (OVX) rats showed 122% increased bone mineral density versus the OVX control at 12weeks after treatment with once weekly oral administration of ZD2 complex (16μg/kg of zoledronic acid). Furthermore, rats treated with ZD2 complex orally showed significant improvement in the parameters of trabecular microarchitecture and bone strength: 149% higher bone volume fraction (BV/TV), 115% higher trabecular number (Tb.N), and 56% higher mean maximum load (Fmax) than in the OVX group. The trabecular microstructure and bone mechanical properties in the oral zoledronic acid group were not significantly changed compared with the OVX control. Thus, the oral ZD2 complex inhibited osteoporosis progression effectively by promoting osteogenesis and trabecular connectivity. The oral ZD2 complex would be expected to improve patient compliance by replacing the conventional injectable form and expand the indications, to include prophylaxis for osteoporosis and bone metastases.
    European journal of pharmaceutical sciences: official journal of the European Federation for Pharmaceutical Sciences 11/2015; 82. DOI:10.1016/j.ejps.2015.11.004 · 3.35 Impact Factor
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    ABSTRACT: The amorphous carbon layer (ACL), used as the hardmask for the etching of nanoscale semiconductor materials, was etched using O2/CHF3 in addition to O2/N2 using pulsed dual-frequency capacitively coupled plasmas, and the effects of source power pulsing for different gas combinations on the characteristics of the plasmas and ACL etching were investigated. As the etch mask for ACL, a patterned SiON layer was used. The etch rates of ACL were decreased with the decrease of pulse duty percentage for both O2/N2 and O2/CHF3 due to decrease of the reactive radicals, such as F and O, with decreasing pulse duty percentage. In addition, at the same pulse duty percentage, the etch selectivity of ACL/SiON with O2/CHF3 was also significantly lower than that with O2/N2. However, the etch profiles of ACL with O2/CHF3 was more anisotropic and the etch profiles were further improved with decreasing the pulse duty percentage than those of ACL with O2/N2. The improved anisotropic etch profiles of ACL with decreasing pulse duty percentage for O2/CHF3 were believed to be related to the formation of a more effective passivation layer, such as a thick fluorocarbon layer, on the sidewall of the ACL during the etching with O2/CHF3, compared to the weak C–N passivation layer formed on the sidewall of ACL when using O2/N2.
    Journal of Nanoscience and Nanotechnology 11/2015; 15(11). DOI:10.1166/jnn.2015.11489 · 1.56 Impact Factor
  • Seung Rim Hwang · In Jae Kim · Jin Woo Park ·
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    ABSTRACT: Introduction: Deoxycholic acid (DOCA) is involved in many physiological functions and has been used in various fields of pharmaceutical formulations as a natural active solubilizing and permeation-enhancing agent. Although DOCA has been suggested to be a promoter of colon cancer, it has also been used extensively as a starting material to obtain new derivatives for potential therapeutic applications. Area covered: In this review, we focus on patents and research reports from 2011 to 2014 related to pharmaceutical formulations and therapeutic applications using DOCA and its derivatives as surfactants or absorption enhancers, drug delivery carriers, and anti-cancer agents. Expert opinion: In recent few years, DOCA and its derivatives have been used mostly as pharmaceutical excipients for solubilizing lipophilic compounds to improve their bioavailability. Other studies have expanded its applications to include enhanced drug permeability and have designed more effective drug carriers by conjugation with polymeric materials. Recently, a synthetic DOCA injection, ATX-101, has shown long-term efficacy in the non-surgical treatment of unwanted submental fat and acceptable tolerability in humans. Thus, it may be used for reducing specific localized fat accumulations. Additionally, DOCA has been a starting material for anti-cancer drugs, and some derivatives showed strong inhibitory activities against several carcinoma cells.
    Expert Opinion on Therapeutic Patents 10/2015; DOI:10.1517/13543776.2016.1102888 · 4.30 Impact Factor
  • Mu Kyeom Mun · Jin Woo Park · Jin Ho Ahn · Ki Kang Kim · Geun Young Yeom ·
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    ABSTRACT: Two key conditions are required for the application of fine-line inkjet printing onto a flexible substrate such as polyimide (PI): linewidth control during the inkjetting process, and a strong adhesion of the polyimide surface to the ink after the ink solidifies. In this study, the properties of a polyimide surface that was roughened through etching in a He/SF6 plasma, using a polystyrene nanosphere array as the etch mask, were investigated. The near-atmospheric-pressure plasma system of the He/SF6 plasma that was used exhibits two notable properties in this context: similar to an atmosphericpressure plasma system, it can easily handle inline substrate processing; and, similar to a vacuum system, it can control the process gas environment. Through the use of plasma etching, the polyimide surface masked the 120-nm-diameter polystyrene nanospheres, thereby forming a roughened nanoscale polyimide surface. This surface exhibited not only a greater hydrophobicity—with a contact angle of about 150° for water and about 30° for silver ink, indicating better silver linewidth control during the silver inkjetting process—but also a stronger adhesion to the silver ink sprayed onto it when compared with the flat polyimide surface.
    Journal of Nanoscience and Nanotechnology 10/2015; 15(10). DOI:10.1166/jnn.2015.11285 · 1.56 Impact Factor
  • Ki Yeun Nam · Changjae Kim · Jin Woo Park · Ho Jun Lee · Bum Sun Kwon ·
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    ABSTRACT: A 4-year-old schizencephaly patient admitted to authors' institution with dysphagia caused by upper esophageal sphincter (UES) dysfunction. Videofluoroscopic swallowing study (VFSS) was done for the diagnosis and the botulinum toxin type A (BTX-A) was injected to the cricopharyngeal muscle. UES dysfunction improved and oral feeding was possible after the injection. This normal swallowing function remained for over 79 months which was confirmed by follow up VFSS. To the best of our knowledge, this is first case of schizencephaly patient to be treated by BTX-A for UES dysfunction and longest to maintain its effect with single session of injection.
    International journal of pediatric otorhinolaryngology 09/2015; DOI:10.1016/j.ijporl.2015.08.011 · 1.19 Impact Factor
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    ABSTRACT: Detection and quantification of 8-oxo-7,8-dihydroguanine (8-oxoG) within cells are important for the study of the molecular mechanisms in cancer. Human ribosomal protein S3 (hRpS3), which involved in DNA repair, has high binding affinity to 8-oxoG. We developed an imaging probe to detect 8-oxoG using a specific peptide of hRpS3. Sequence analysis was conducted to elucidate the 8-oxoG-specific binding region of hRpS3, and three truncated mutants, D1 (amino acids 1–85), D2 (amino acids 86–159), and D3 (amino acids 160–242), were constructed. Both wild-type-hRpS3 and D2 were able to bind 8-oxoG, which is consistent with the results of a previous report on the role of K134 in Drosophila melanogaster RpS3. We synthesized a specific peptide and covalently linked with a fluorophore (FPR-552, similar to Cy3) to generate an 8-oxoG imaging probe. Our 8-oxoG S3-probe successfully detected the presence of 8-oxoG in damaged cells. Furthermore, this probe has threefold higher sensitivity than 8-oxoG DNA lesion antibody.
    Bulletin of the Korean Chemical Society 09/2015; 36(10):n/a-n/a. DOI:10.1002/bkcs.10472 · 0.80 Impact Factor
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    ABSTRACT: Aqueous precursor solutions prepared by water-soluble molecular precursors, CuCl2, InCl3, GaCl3, and SeC(NH2)2, have been successfully employed to deposit Cu(InGa)Se2 thin-film solar cell absorbers by spray-deposition followed by selenization. The spray-deposition process was optimized by adjusting the spray operation parameters (e.g., spray flow rate, time, and spray distance from substrate) and the substrate conditions (e.g., rotational speed and substrate temperature). The selenization process was then adjusted by changing the selenization temperature and Se flux. Here we report a cell efficiency of 4.7% obtained from spray-deposition of an aqueous precursor followed by selenization in a vacuum thermal evaporator.
    Journal of Nanoelectronics and Optoelectronics 08/2015; 10(4). DOI:10.1166/jno.2015.1804 · 0.39 Impact Factor
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    ABSTRACT: Histone lysine methylation contributes to transcriptional regulation by serving as a platform for the recruitment of various cofactors. Intense studies have been conducted for elucidating the functional meaning of H3K79 methylation, and to date, the only known HMTase responsible for the modification was DOT1L. In this study, we report that the MMSET isoform RE-IIBP has HMTase activity for H3K79. It was uncovered that RE-IIBP up-regulates MEIS1 transcription through H3K79 methylation via recruitment to the MEIS1 promoter. By means of proteomic and biochemical analysis, association of RE-IIBP with the E3 ubiquitin ligase RNF20 was demonstrated for synergistic activation of MEIS1 transcription via H3K79 HMTase activity. Furthermore, It was observed that RE-IIBP induces MEIS1-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20. These findings suggest RE-IIBP as another candidate for further studies to elucidate the mechanism of H3K79 methylation and its biological functions.
    Scientific Reports 07/2015; 5:12485. DOI:10.1038/srep12485 · 5.58 Impact Factor
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    ABSTRACT: In recent years, advances in biotechnology and protein engineering have enabled the production of large quantities of proteins and peptides as important therapeutic agents. Various researchers have used biocompatible functional polymers to prepare oral dosage forms of proteins and peptides for chronic use and for easier administration to enhance patient compliance. However, there is a need to enhance their safety and effectiveness further. Most macromolecules undergo severe denaturation at low pH and enzymatic degradation in the gastrointestinal tract. The macromolecules' large molecular size and low lipophilicity cause low permeation through the intestinal membrane. The major strategies that have been used to overcome these challenges (in oral drug carrier systems) can be classified as follows: enteric coating or encapsulation with pH-sensitive polymers or mucoadhesive polymers, co-administration of protease inhibitors, incorporation of absorption enhancers, modification of the physicochemical properties of the macromolecules, and site-specific delivery to the colon. This review attempts to summarize the various advanced oral delivery carriers, including nanoparticles, lipid carriers, such as liposomes, nano-aggregates using amphiphilic polymers, complex coacervation of oppositely charged polyelectrolytes, and inorganic porous particles. The particles were formulated and/or surface modified with functional polysaccharides or synthetic polymers to improve oral bioavailability of proteins and peptides. We also discuss formulation strategies to overcome barriers, therapeutic efficacies in vivo, and potential benefits and issues for successful oral dosage forms of the proteins and peptides.
    Current pharmaceutical design 05/2015; 21(22). DOI:10.2174/1381612821666150531163944 · 3.45 Impact Factor
  • Joonho Bae · Jin Woo Park ·
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    ABSTRACT: We investigated whether leflunomide can be delivered topically and metabolized into teriflunomide through the skin, and evaluated the therapeutic effect of topical leflunomide. Permeation of leflunomide across and formation of its active metabolite within the skin was examined ex vivo. Deposition of teriflunomide in micropig knee joints after applying topical and transdermal patches containing leflunomide was investigated by determining the plasma and joint tissue concentrations. Finally, the anti-inflammatory effects and inhibition of skin sensitization by topical leflunomide were evaluated in a rat adjuvant arthritis model and mice with delayed-type induced hypersensitivity. We found that after topical application of leflunomide on freshly excised mouse, rat and guinea pig skin, ∼24% of the permeated drug existed as teriflunomide. In micropigs treated topically with leflunomide on the knee joint, significantly lower teriflunomide concentrations were found in plasma, but its concentrations in the knee joint were 3.4-fold to 54.6-fold higher than those after oral administration. In a rat arthritis model, the plasma concentration of teriflunomide after treatment with 10% leflunomide topical solution was 7.54-fold lower than that after 10 mg/kg oral leflunomide. However, topical leflunomide was nearly as effective as oral in inhibiting paw edema (37% versus 56%, respectively). The values for hypersensitized mouse ear weight after treatment with topical leflunomide decreased significantly by 26% compared to vehicle. These results demonstrate that topically applied leflunomide can be delivered effectively and deposited as teriflunomide in an arthritic joint, possibly allowing better compliance in rheumatoid arthritis patients by avoiding leflunomide's side effects.
    Drug Development and Industrial Pharmacy 05/2015; DOI:10.3109/03639045.2015.1044906 · 2.10 Impact Factor
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    ABSTRACT: Impaired facial emotion recognition is a core deficit in schizophrenia. Oxytocin has been shown to improve social perception in patients with schizophrenia; however, the effect of oxytocin on the neural activity underlying facial emotion recognition has not been investigated. This study was aimed to assess the effect of a single dose of intranasal oxytocin on brain activity in patients with schizophrenia using an implicit facial emotion recognition paradigm. Sixteen male patients with schizophrenia and 16 age-matched healthy male control subjects participated in a randomized, double blind, placebo-controlled crossover trial at Seoul National University Hospital. Delivery of a single dose of 40 IU intranasal oxytocin and the placebo was separated by 1 week. Drug conditions were compared by performing a region of interest (ROI) analysis of the bilateral amygdala on responses to the emotion recognition test. It was found that nasal spray decreased amygdala activity for fearful emotion and increased activity for happy faces. Further, oxytocin elicited differential effects between the patient and control groups. Intranasal oxytocin attenuated amygdala activity for emotional faces in patients with schizophrenia, whereas intranasal oxytocin significantly increased amygdala activity in healthy controls. Oxytocin-induced BOLD signal changes in amygdala in response to happy faces was related to attachment style in the control group. Our result provides new evidence of a modulatory effect of oxytocin on neural response to emotional faces for patients with schizophrenia. Future studies are needed to investigate the effectiveness of long-term treatment with intranasal oxytocin on neural activity in patients with schizophrenia.Neuropsychopharmacology accepted article preview online, 10 February 2015. doi:10.1038/npp.2015.41.
    Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 02/2015; 40(8). DOI:10.1038/npp.2015.41 · 7.05 Impact Factor
  • Joonho Bae · Jin Woo Park ·
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    ABSTRACT: We prepared an injectable depot system for the long-term delivery of alendronate using a solid/water/oil/water multiple emulsion technique with poly(lactic-co-glycolic acid) as a carrier. The microparticles were spherical with smooth surfaces, ranging from 20 to 70μm in size. The microspheres (ALD-HA-RG504H-MC70) were optimally prepared by introducing a viscous material (hyaluronic acid) and a co-solvent system in the inner aqueous and oil phases, respectively, and showed a significantly increased drug encapsulation efficacy (>70%); the initial burst release was <10% after 1 day. In vitro drug release from ALD-HA-RG504H-MC70 followed zero-order kinetics for approximately 4 weeks and the alendronate plasma level was maintained for more than 1 month after intramuscular injection in rabbits. The ovariectomized (OVX) rats with ALD-HA-RG504H-MC70 injected intramuscularly (0.9mg alendronate/kg/4 weeks) had 112% and 482% increased bone mineral density and trabecular area in the tibia than the OVX controls, respectively, and showed significant improvements in trabecular microarchitecture and bone strength. Furthermore, the major biomarkers of bone turnover revealed that ALD-HA-RG504H-MC70 suppressed effectively the progression of osteoporosis and facilitated new bone formation. Therefore, this sustained release depot system may improve patient compliance and therapeutic efficacy by reducing dose amounts and frequency with minimal adverse reactions. Copyright © 2015. Published by Elsevier B.V.
    International Journal of Pharmaceutics 01/2015; 480(1-2). DOI:10.1016/j.ijpharm.2015.01.020 · 3.65 Impact Factor
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    ABSTRACT: Benign paroxysmal positional vertigo (BPPV) generally involves a single semicircular canal (single canal BPPV) but it has been reported that more than one semicircular canal on either the same or the opposite side can be involved in 6.8-20% of the cases (multiple canal BPPV). In this study, the clinical characteristics of multiple canal BPPV were analyzed and compared to those of single canal BPPV. Retrospective analysis was performed on 1054 consecutive patients diagnosed with BPPV. Multiple canal BPPV was diagnosed when the combination of typical nystagmus was provoked by the Dix-Hallpike and supine head roll tests. Canalith repositioning maneuver was performed sequentially starting with the semicircular canal causing more severe nystagmus or symptoms. Clinical characteristics and the treatment course were statistically compared between single canal BPPV and multiple canal BPPV. Among the 1054 patients, single canal BPPV was diagnosed in 1005 patients (95.4%) while multiple canal BPPV was diagnosed in 49 patients (4.6%). BPPV involving semicircular canals on the same side was more common (79.6%) than BPPV with bilateral involvement. The most common combination of the involved canals was ipsilateral posterior and horizontal semicircular canals (63.3%). Multiple canal BPPV was significantly more associated with underlying otologic diseases, especially labyrinthitis. Multiple canal BPPV required more treatment sessions and longer duration of treatment to achieve resolution of nystagmus and symptoms. As all cases of multiple canal BPPV were treated successfully although a longer duration of treatment and more treatment sessions were required compared to single canal BPPV, the results of our study could aid in making an accurate diagnosis and providing appropriate treatment of multiple canal BPPV.
    Korean Journal of Audiology 12/2014; 18(3):126-30. DOI:10.7874/kja.2014.18.3.126
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    ABSTRACT: Here we report that the H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. Negative regulation of ANGPT1 by KDM3B is independent of its Jumanji (JmjC) domain-mediated H3K9 demethylase activity. We demonstrate that KDM3B downregulates ANGPT1 via interaction with SMRT, and suggest that the repressor complex is formed at the promoter area of ANGPT1. Using MTT and wound healing assays, depletion of KDM3B was found to increase cell proliferation and cell motility, indicating that KDM3B has a role in angiogenesis.
    BMB reports 11/2014; 48(7). DOI:10.5483/BMBRep.2015.48.7.188 · 2.60 Impact Factor
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    ABSTRACT: The therapeutic efficacy of radioiodine (131I) therapy has been reported to be variable among cancer patients and even between metastatic regions in the same patients. Because the expression level of sodium iodide symporter (NIS) cannot reflect the efficacy of therapy, other strategies are required to predict the precise therapeutic effect of 131I therapy. In this research, we investigated the correlation between iodine (I) uptake, apoptosis imaging, and therapeutic efficacy. Two HT29 cell lines, cytomegalovirus (CMV)-NIS (or NIS+++) and TERT-NIS (or NIS+), were established by retroviral transfection. I uptake was estimated by I-uptake assay and gamma camera imaging. Apoptosis was evaluated by confocal microscopy and a Maestro fluorescence imaging system (CRi Inc., Woburn, MA) using ApoFlamma (BioACTs, Seoul, Korea), a fluorescent dye-conjugated apoptosis-targeting peptide 1 (ApoPep-1). Therapeutic efficacy was determined by tumor size. The CMV-NIS showed higher I uptake and ApoFlamma signals than TERT-NIS. In xenograft models, CMV-NIS also showed high 99m technetium signals and ApoFlamma signals. Tumor reduction had a stronger correlation with apoptosis imaging signals than with gamma camera imaging signals, which reflect I uptake. Higher NIS-expressing tumors showed increased apoptosis and I uptake, resulting in a significant tumor reduction. Moreover, tumor reduction showed a strong correlation with ApoFlamma imaging compared to I-uptake imaging.
    Molecular Imaging 11/2014; 13:1-9. DOI:10.2310/7290.2014.00050 · 1.96 Impact Factor
  • Junho Won · Jin Woo Park ·
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    ABSTRACT: Purpose: To assess the ability of radiofrequency (RF) microporation to promote trans-epidermal delivery of arbutin. Methods: To investigate the enhancing effect of RF microchannels on skin permeation of arbutin, in vitro skin permeability studies were performed with RF microporation-treated Hartley albino guinea pig skin using Franz diffusion cell system. Furthermore, improved depigmentation effects in brown guinea pig in vivo after treatment with RF microporation was evaluated to create hydrophilic microchannels for arbutin trans-epidermal delivery. Results: RF microporator caused disruption of the stratum corneum (SC) and created 50 mu m diameter microchannels at a depth of 100 mu m in the skin. RF microporation increased skin permeability of arbutin 2.25-fold compared to untreated skin exposed to RF in vitro. Arbutin administration led to considerable skin depigmentation following RF microporation of UV-induced hyperpigmented skin in a 28-day in vivo experiment (Delta L-value on day 28: UV, 0.17 +/- 0.50; UV + RF, 0.07 +/- 0.48; UV + arbutin, 1.32 +/- 0.51 and UV + RF + arbutin, 1.82 +/- 0.53). Conclusion: RF microporation seems to be a suitable physical trans-epidermal delivery technology for topical application of highly hydrophilic depigmentation agents through the hydrophobic skin barrier.
    Tropical Journal of Pharmaceutical Research 11/2014; 13(11):1775-1781. DOI:10.4314/tjpr.v13i11.1 · 0.50 Impact Factor
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    Il-Hong Bae · Jin Woo Park · Dae-Yong Kim ·
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    ABSTRACT: Exogenous administration of growth factors has potential benefits in wound healing; however, limited percutaneous absorption, inconsistent efficacy, and the need for high doses have hampered successful clinical use. To overcome these restrictions, we focused on the development of a topical formulation composed of highly skin-permeable multimeric nanocomplex of growth factors. In the present study, we fused low-molecular-weight protamine (LMWP) with epidermal growth factor (EGF), insulin-like growth factor 1 (IGF-I), and platelet-derived growth factor A ligand (PDGF-A) (producing recombinant [r]LMWP-EGF, rLMWP-IGF-I, and rLMWP-PDGF-A, respectively) via genetic modification. Then, we used in vitro cell proliferation studies to assess the biological activity and the benefits of the combination. The LMWP-conjugated growth factors were complexed with low-molecular-weight heparin (LMWH) and formulated with Poloxamer 188 as a delivery vehicle. After confirming the enhanced skin permeability, in vivo studies were performed to assess whether the LMWP-conjugated growth factor nanocomplex formulations accelerated the healing of full-thickness wounds in mice. The LMWP-conjugated growth factors were biologically equivalent to their native forms, and their combination induced greater fibroblast proliferation. rLMWP-EGF showed significantly enhanced permeability and cumulative permeation, and the rates for rLMWP-IGF-I and rLMWP-PDGF-A, across excised mouse skin, were 124% and 164% higher, respectively, than for the native forms. The LMWP-fused growth factors resulted in formation of nanocomplexes (23.51±1.12 nm in diameter) in combination with LMWH. Topical delivery of growth factors fused with LMWP accelerated wound re-epithelialization significantly, accompanied by the formation of healthy granulation tissue within 9 days compared with a free-growth factor complex or vehicle. Thus, the LMWP-conjugated growth factor nanocomplex can induce rapid, comprehensive healing and may be a candidate wound-healing therapeutic.
    International Journal of Nanomedicine 09/2014; 9:4551-67. DOI:10.2147/IJN.S68399 · 4.38 Impact Factor
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    ABSTRACT: As the main input hub of the basal ganglia, the striatum receives projections from the cerebral cortex. Many studies have provided evidence for multiple parallel corticostriatal loops based on the structural and functional connectivity profiles of the human striatum. A recent resting-state fMRI study revealed the topography of striatum by assigning each voxel in the striatum to its most strongly correlated cortical network among the cognitive, affective, and motor networks. However, it remains unclear what patterns of striatal parcellation would result from performing the clustering without subsequent assignment to cortical networks. Thus, we applied unsupervised clustering algorithms to parcellate the human striatum based on its functional connectivity patterns to other brain regions without any anatomically or functionally defined cortical targets. Functional connectivity maps of striatal subdivisions, identified through clustering analyses, were also computed. Our findings were consistent with recent accounts of the functional distinctions of the striatum as well as with recent studies about its functional and anatomical connectivity. For example, we found functional connections between dorsal and ventral striatal clusters and the areas involved in cognitive and affective processes, respectively, and between rostral and caudal putamen clusters and the areas involved in cognitive and motor processes, respectively. This study confirms prior findings, showing similar striatal parcellation patterns between the present and prior studies. Given such striking similarity, it is suggested that striatal subregions are functionally linked to cortical networks involving specific functions rather than discrete portions of cortical regions. Our findings also demonstrate that the clustering of functional connectivity patterns is a reliable feature in parcellating the striatum into anatomically and functionally meaningful subdivisions. The striatal subdivisions identified here may have important implications for understanding the relationship between corticostriatal dysfunction and various neurodegenerative and psychiatric disorders.
    PLoS ONE 09/2014; 9(9):e106768. DOI:10.1371/journal.pone.0106768 · 3.23 Impact Factor
  • Huanyu Zhou · Jin‐Woo Park ·
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    ABSTRACT: In this study, we investigated the factors that determine the efficiency of flexible organic light emitting diodes (f-OLEDs) in relation to transparent conductive electrodes (TCE). Indium tin oxide (ITO) was selected as the TCE and was deposited on polyimide substrates. Controlling the sputtering conditions, ITOs with various degrees of crystallinity were made. Flexible OLEDs (f-OLED) were fabricated on the ITOs, and the current density (J)–luminescence (L)–voltage (V) characteristics of the f-OLEDs were evaluated. The experimental results revealed that the sheet carrier density and surface roughness of ITO are significantly increased and reduced, respectively, as the film crystallinity increased over a certain degree. Based on our X-ray photoelectron spectroscopy (XPS) analysis, chemical bonds formed between the mostly crystallized ITO and a hole transfer layer (HTL) in f-OLEDs, deposited on ITO. To the contrary, In and Sn of the less crystallized ITO diffused into HTL with no formation of interfacial bonds, which may become barriers to carrier flows through HTL. The f-OLED on the mostly crystalline ITO showed significantly better J–L–V characteristics than on the less crystallized ITO, which proved that the crystallinity of ITO is the critical factor that determines the performance of the flexible organic devices constructed on the ITO.
    Physica Status Solidi (A) Applications and Materials 09/2014; 212(2). DOI:10.1002/pssa.201431550 · 1.62 Impact Factor

Publication Stats

792 Citations
227.72 Total Impact Points


  • 2015
    • Yeungnam University
      • School of Chemical Engineering
      경산시, Gyeongsangbuk-do, South Korea
  • 2013-2015
    • Mokpo National University
      • College of Pharmacy
      Mokuho, Jeollanam-do, South Korea
    • Vietnam Academy of Science and Technology
      • Institute of Materials Science
      Kanh-Hoa, Khánh Hòa, Vietnam
    • Gyeongsang National University
      • School of Materials Science and Engineering
      Shinshū, South Gyeongsang, South Korea
    • Chosun University
      Gwangju, Gwangju, South Korea
    • Chung-Ang University
      • College of Natural Sciences
      Sŏul, Seoul, South Korea
  • 2001-2015
    • Seoul National University Hospital
      • • Department of Neuropsychiatry
      • • Department of Anesthesiology and Pain Medicine
      • • Department of Rehabilitation Medicine
      Sŏul, Seoul, South Korea
    • Hanyang University Medical Center
      Sŏul, Seoul, South Korea
  • 2013-2014
    • Myongji Hospital
      Kōyō, Gyeonggi-do, South Korea
  • 2010-2014
    • Yonsei University
      • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
    • University of Seoul
      • Depatrment of Materials Science and Engineering
      Sŏul, Seoul, South Korea
  • 2002-2014
    • Seoul National University
      • • School of Mechanical and Aerospace Engineering
      • • College of Pharmacy
      Sŏul, Seoul, South Korea
  • 2012-2013
    • Sungkyunkwan University
      • School of Advanced Materials Science and Engineering (AMSE)
      Sŏul, Seoul, South Korea
    • Amorepacific Corporation
      Sŏul, Seoul, South Korea
    • National Academy of Agricultural Science (South Korea)
      Sŏul, Seoul, South Korea
      Seikan-ri, Chungcheongnam-do, South Korea
    • Dongguk University
      Sŏul, Seoul, South Korea
    • Konkuk University
      • Department of Advanced Technology Fusion (ATF)
      Seoul, Seoul, South Korea
    • Amore Pacific
      New York, New York, United States
  • 2000-2013
    • Hanyang University
      • • Division of Chemical Engineering and Bioengineering
      • • Department of Physics
      Sŏul, Seoul, South Korea
  • 2011
    • Chungbuk National University
      Chinsen, Chungcheongbuk-do, South Korea
    • Korea Aerospace University
      • Department of Business Administration
      Kōyō, Gyeonggi-do, South Korea
    • Union Corporation, South Korea
      Sŏul, Seoul, South Korea
  • 2001-2011
    • Korea University
      • Department of Electrical Engineering
      Sŏul, Seoul, South Korea
  • 1999-2010
    • Soonchunhyang University
      • College of Medicine
      Onyang, Chungcheongnam-do, South Korea
    • Korea Institute of Science and Technology
      Sŏul, Seoul, South Korea
  • 2002-2009
    • Chonbuk National University
      • School of Medicine
      Tsiuentcheou, North Jeolla, South Korea
  • 2008
    • Pusan National University
      • Division of Electrical and Electronics Engineering
      Tsau-liang-hai, Busan, South Korea
  • 1999-2005
    • Kyungpook National University
      • • Department of Polymer Science and Engineering
      • • Department of Electronic Engineering
      • • Department of Electrical Engineering
      Daikyū, Daegu, South Korea
  • 2004
    • Korea Hydro and Nuclear Power - Central Research Institute
      Sŏul, Seoul, South Korea
  • 1998
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea