J.O. Olsen

Publications (2)0 Total impact

• Source

  Available from: lw23.com

  Conference Proceeding: Localization and Functional Parameter Reconstruction of Suspicious Breast Lesions by Near Infrared/Ultrasound Dual Modal Imaging

  R.X. Xu, Bo Qiang, J.O. Olsen, S.P. Povoski, L.D. Yee, J. Mao
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  ABSTRACT: A novel imaging scheme integrating a continuous wave (CW) hand held near infrared tissue imager and a portable ultrasound probe was proposed for evaluation of suspicious breast lesions. A new methodology was developed to reconstruct functional properties of the lesion and the surrounding tissue based on the optical measurement of the diffusive light and the ultrasound measurement of the tumor morphology. The first order Born approximation was used to solve the absorption coefficients for both the tumor tissue and the background tissue assuming that optical properties within each tissue type are uniform. A compression force was applied by the handheld near infrared imager to the breast tissue in order to enhance the optical contrast. The force was monitored by a built-in load cell. 2D projection algorithm was used to find the center of the tumor and to co-register the near infrared image with the ultrasound image. The proposed imaging scheme was tested by a clinical trial where both near infrared and ultrasound data were collected on subjects' breast tissues with embedded suspicious lesions. 3D image algorithm on single patient successfully reconstructed the oxygen saturation and the hemoglobin concentration in both the tumor area and the surrounding tissue. More data collection and analysis are required to confirm this imaging scheme
  Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the; 02/2006
• Article: Biomedical Optics 2006

  R. X. Xu, S. P. Povoski, L. D. Yee, J. O. Olsen, B. Qiang, J. M. Mao
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  ABSTRACT: For characterization of suspicious breast lesions, we used a dual modal imaging scheme integrating a hand-held near infrared imager and a portable ultrasound probe. The functional properties of the suspicious lesion and the surrounding tissue were reconstructed based on the diffuse reflectance measurement of the near infrared light and the ultrasound measurement of the tumor morphology. The near infrared/ultrasound dual modal imaging system has been validated through a series of bench top tests where tumor simulators with various absorptions were embedded at different depth in a liquid tissue-simulating phantom. The clinical trial of the imaging scheme was conducted on 44 subjects with suspicious breast lesions identified by mammography and/or ultrasound. Both near infrared and ultrasound data were collected from the area of the suspicious breast lesion and from the adjacent reference breast tissue. The clinical trial demonstrates that the dual modal imaging system can reach up to 71% of diagnostic sensitivity and 58% of specificity in detecting breast carcinoma. This may indicate that the system could potentially be used in breast cancer detection adjunctive with mammography.© (2006) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
  02/2006;