Hanka Mlčochová

Institute for Clinical and Experimental Medicine (IKEM), Praha, Praha, Czech Republic

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Publications (7)14.23 Total impact

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    ABSTRACT: Worldwide Survey on Robotic AF Ablation. Introduction: The Hansen Robotic system has been utilized in ablation procedures for atrial fibrillation (AF). However, because of the lack of tactile feedback and the rigidity of the robotic sheath, this approach could result in higher risk of complications. This worldwide survey reports a multicenter experience on the methodology, efficacy, and safety of the Hansen system in AF ablations. Methods and Results: A questionnaire addressing questions on patient's demographics, procedural parameters, ablation success rate and safety information was sent to all centers where more than 50 robotic AF ablation cases have been performed. From June 2007 to December 2009, 1,728 procedures were performed at 12 centers utilizing the Hansen robotic navigation technology. The overall complication rate was 4.7% and the success rate was 67.1% after 18 ± 4 months of follow-up. In 5 low volume centers there appeared to be a learning curve of about 50 cases (complication rate 11.2% for the first 50 cases vs 3.7% for the 51-100 cases; P = 0.044) and a trend showing a decrease of complication rate with increasing case volume. However, in the remaining 7 centers no learning curve was present and the complication rate was stable over time (3.7% for the first 50 cases vs 3.6% for the 51st case thereafter; P = 0.942). Conclusion: The Hansen robotic system can be used for AF ablation safely. In low volume centers, there appeared to be a learning curve of the first 50 cases after which the complication rate decreased. With a higher case volume, the success rate increased. (J Cardiovasc Electrophysiol, Vol. 23, pp. 820-826, August 2012).
    Journal of Cardiovascular Electrophysiology 04/2012; 23(8):820-826. · 3.48 Impact Factor
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    ABSTRACT: The objective of this study was to compare long-term clinical effects of biventricular pacing with isolated left ventricular pacing. Forty consecutive patients with idiopathic dilated cardiomyopathy and indication for cardiac resynchronization therapy were randomized to biventricular or isolated left ventricular pacing. Clinical and echocardiographic parameters were studied regularly prior to implantation and during 1 year of follow-up. Patients with atrial fibrillation were excluded from the study. A retrospective cross-sectional outcome analysis was performed 4 years after the beginning of the study. Biventricular pacing was associated with more pronounced clinical and echocardiographic benefit compared with left ventricular pacing. Biventricular pacing was associated with significantly more distinct reverse remodelling. Left ventricular ejection fraction improved by 12.5 per cent-points (95% CI 7.3-17.7) compared with 5.1 per cent-points (95% CI 1.1-9.2) (P = 0.01) and left ventricular end-diastolic diameter decreased by 8.69 mm (95% CI 5.2-12.2) compared with 5.1 mm (95% CI 1.5-8.7) (P = 0.05) in the biventricular and left-ventricular pacing group, respectively. Semi-quantitative summarization of response points revealed a greater benefit in the biventricular vs. left ventricular pacing group [mean sum of response points 3.25 (95% CI 2.62-3.88) vs. 2.35 (95% CI 1.74-2.96), respectively, P = 0.06]. After 3 years of follow-up, there was no cardiovascular death in the biventricular pacing group compared with three cardiovascular deaths in the left ventricular pacing group. In patients with idiopathic dilated cardiomyopathy, biventricular pacing is associated with significantly more pronounced benefit in clinical outcomes and reverse remodelling. A retrospective analysis after 3 years of follow-up suggests that isolated left ventricular pacing may be associated with a higher mortality rate compared with biventricular pacing.
    Europace 12/2010; 12(12):1762-8. · 2.77 Impact Factor
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    ABSTRACT: Catheter ablation of periatrioventricular (peri-AV) nodal atrial tachycardias (AT) from the noncoronary aortic cusp (NCC) can be challenging due to the close proximity of the AV node . In such cases, intracardiac echocardiography (ICE) together with three-dimensional mapping system can be helpful in guiding the ablation catheter and in assessing the anatomic relationship of the aorta to the surrounding structures. We report two patients with AT originating near the AV node who underwent successful catheter ablation from the NCC. ICE proved useful in positioning the ablation catheter within the aortic cusps. Electroanatomic mapping enabled tagging the earliest activation site and renavigation back. (PACE 2010; 1-4).
    Pacing and Clinical Electrophysiology 12/2010; · 1.75 Impact Factor
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    ABSTRACT: Remote navigation systems represent a novel strategy for catheter ablation of atrial fibrillation (AF). The goal of this study is to describe a single-center experience with the electromechanical robotic system (Sensei, Hansen Medical) in treatment of patients with paroxysmal AF. Out of 200 patients who underwent robotically guided ablation for AF between 2007 and 2009 at our institute, 100 patients (29 women, age 56.5 ± 10 years) had paroxysmal AF refractory to antiarrhythmic drugs. Electroanatomic mapping using NavX system (St. Jude Medical) provided anatomical shell for subsequent circumferential ablation with robotic catheter (Artisan) loaded with a 3.5-mm, open-irrigation, cooled-tip ablation catheter. A mean of 69 radiofrequency current applications (duration 2082 ± 812 seconds) were delivered to achieve circumferential electrical isolation of pulmonary venous antra. Total procedural time reached 222 ± 54 minutes. The mean fluoroscopic time was 11.9 ± 7.8 minutes. There were no major procedure-related complications. After a median follow-up of 15 months (range 3-28 months), 63% of the patients were free from any atrial arrhythmias ≥ 30 seconds after the single procedure. Success rate increased to 86% after 1.2 procedures. Multivariate analysis revealed that only predictor of recurrent AF/AT was shorter overall procedural time (207 ± 36 vs 236 ± 64 minutes in patients with and without recurrences, respectively, P = 0.0068). This study demonstrates feasibility and safety of robotic navigation in catheter ablation for paroxysmal AF. Midterm follow-up documents success rate comparable to other technologies and potential for improvement in more extensive ablation along the ridges with thicker myocardium.
    Journal of Cardiovascular Electrophysiology 11/2010; 22(5):534-40. · 3.48 Impact Factor
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    J. Kautzner, H. Mlcochova, P. Peichl
    12/2005: pages 179-187;
  • J. Kautzner, P. Peichl, H. Mlcochova
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    ABSTRACT: Catheter ablation of atrial fibrillation (AF) has become a real therapeutic option for symptomatic patients resistant to or intolerant of antiarrhythmic drugs. Since the first reports of curative catheter ablation a decade ago, several techniques have evolved [1-5]. Despite the fact that these techniques vary significantly, they all have something in common: the predominant target has become the left atrium and pulmonary veins (PVs). Underestimated by many operators, the variability of the anatomy makes the procedure complex and seems to explain most failures and/or complications. The aim of this review is to discuss the importance of imaging techniques for guidance of catheter ablation of AF.
    12/2004: pages 119-128;
  • Europace 01/2003; 4. · 2.77 Impact Factor