Publications (2)0.93 Total impact

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    ABSTRACT: The objectives of the present study were to investigate human epidermal growth factor receptor-2 (HER2) and topoisomerase II alpha (T2a) expressions in rectal cancer (RC) and to evaluate their correlation. The status of HER2 and T2a in tumor specimens from 302 RC patients was retrospectively assessed using immunohistochemistry. Clinicopathological parameters were compared. HER2 overexpression (2+ or 3+) was found in only 31 patients (10.3%), whereas positive immunostaining for the T2a protein was detected in most patients (n=272, 90.1%). HER2 expression tended to positively correlate with T2a level (r=0.224; p<0.001). Relationships between HER2 expression and patients' age and gender, tumor size, differentiation, and TNM stage, lymph node metastasis, and lymphovascular invasion were not found (p>0.05). Logistic regression analysis identified TNM stage III and lymphovascular invasion as independent risk factors for T2a overexpression (p<0.05). As the contribution of HER2 appears minimal, it has low potential as a therapeutic target in RC. T2a may play an important role in cancer cell progression and invasion, and T2a inhibitors could be used in the treatment of RC.
    Hepato-gastroenterology 03/2011; 58(106):359-63. · 0.93 Impact Factor
  • Luo Haojie · Zhang Dongdong · Ye Chen
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    ABSTRACT: In this paper, we proposed a novel network coding method called local-directed network coding to improve the throughput of the vehicular ad-hoc network. Different from other vehicular network coding methods, we consider the direction of packet transmission. In detail, the intermediate node selects one main packet and some sub-packets from forwards and backwards sending queues, and then encodes these packets into one packet to broadcast. Simulation results show that our approach can efficiently improve the throughput of application layer in vehicular networks.
    Intelligent Signal Processing and Communication Systems (ISPACS), 2010 International Symposium on; 01/2011